Výsledky vyhledávání - "Santhosh Bommegowda"

Preclinical Characterization of Vadadustat (AKB-6548), an Oral Small Molecule Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, for the Potential Treatment of Renal Anemia

Autor: Anna Zuk, Zhihai Si, Sally Loi, Santhosh Bommegowda, Debie Hoivik, Sanjay Danthi, Gyongyi Molnar, Vilmos Csizmadia, Michael Rabinowitz

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 383:11-24

Pharmacological inhibition of prolyl-4-hydroxylase domain (PHD) enzymes stabilizes hypoxia-inducible factors (HIFs), transcription factors that activate target genes that, among others, increase erythropoietin (EPO) synthesis, resulting in the produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212ebca1120f2d693be7ff991a9b7695
https://doi.org/10.1124/jpet.122.001126

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