Zobrazeno 1 - 10
of 771
pro vyhledávání: '"Santhosh, M."'
Autor:
James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Gregory A. Coffee, Yee-Hsee Hsieh, Zackery T. Knauss, Albert Dahan, Jason A. Bubier, Peter M. MacFarlane, Devin Mueller, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract N-acetyl-L-cysteine (L-NAC) is a proposed therapeutic for opioid use disorder. This study determined whether co-injections of L-NAC (500 μmol/kg, IV) or its highly cell-penetrant analogue, L-NAC methyl ester (L-NACme, 500 μmol/kg, IV), pre
Externí odkaz:
https://doaj.org/article/7cf134f1aa4b40f786d4d28221785b6e
Autor:
Paulina M. Getsy, Gregory A. Coffee, James N. Bates, Theodore Parran, Lee Hoffer, Santhosh M. Baby, Peter M. MacFarlane, Zackery T. Knauss, Derek S. Damron, Yee-Hsee Hsieh, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The ability of morphine to decrease cysteine transport into neurons by inhibition of excitatory amino acid transporter 3 (EAA3) may be a key molecular mechanism underlying the acquisition of physical and psychological dependence to morphine. This stu
Externí odkaz:
https://doaj.org/article/25505fc3abd147f1bfb54bb923d7270b
Autor:
Paulina M. Getsy, Walter J. May, Alex P. Young, Santhosh M. Baby, Gregory A. Coffee, James N. Bates, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Our lab is investigating the efficacy profiles of tropine analogs against opioid-induced respiratory depression. The companion manuscript reports that the cell-permeant tropeine, tropine ester (Ibutropin), produces a rapid and sustained reversal of t
Externí odkaz:
https://doaj.org/article/206aecfd4bd54baca01b5da85e16ff77
Autor:
Santhosh M. Baby, Walter J. May, Paulina M. Getsy, Gregory A. Coffee, Tej Nakashe, James N. Bates, Alan Levine, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Fentanyl elicits profound disturbances in ventilatory control processes in humans and experimental animals. The traditional viewpoint with respect to fentanyl-induced respiratory depression is that once the effects on the frequency of breathing (Freq
Externí odkaz:
https://doaj.org/article/18e3f66e88b64ca59062ba0937b3b4e6
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse
Externí odkaz:
https://doaj.org/article/5ab96a619e0f445aae20d91926abf672
Autor:
Amudhavalli, A., Dharmaraj, P., Manikandan, M., Santhosh, M., RajeswaraPalanichamy, R., Iyakutti, K.
Publikováno v:
In Chinese Journal of Physics June 2024 89:1116-1127
Autor:
Santhosh M. Baby, Walter J. May, Alex P. Young, Christopher G. Wilson, Paulina M. Getsy, Gregory A. Coffee, Tristan H.J. Lewis, Yee-Hee Hsieh, James N. Bates, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116081- (2024)
L-cysteine ethylester (L-CYSee) is a membrane-permeable analogue of L-cysteine with a variety of pharmacological effects. The purpose of this study was to determine the effects of L-CYSee on morphine-induced changes in ventilation, arterial-blood gas
Externí odkaz:
https://doaj.org/article/700e8d74e6a44a1294fa6ee737f3d673
Autor:
Baby, Santhosh M., May, Walter J., Young, Alex P., Wilson, Christopher G., Getsy, Paulina M., Coffee, Gregory A., Lewis, Tristan H.J., Hsieh, Yee-Hee, Bates, James N., Lewis, Stephen J.
Publikováno v:
In Biomedicine & Pharmacotherapy February 2024 171
Autor:
Paulina M. Getsy, Gregory A. Coffee, Walter J. May, Santhosh M. Baby, James N. Bates, Stephen J. Lewis
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 498 (2024)
The present study examined the hypothesis that changes in the oxidation–reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic–hyperc
Externí odkaz:
https://doaj.org/article/c8977dbe30884ca2a11ef14cb3934e50
Publikováno v:
Phys. Rev. B 103, 195141 (2021)
We numerically study quenches from a fully ordered state to the ferromagnetic regime of the chiral $\mathbb{Z}_3$ clock model, where the physics can be understood in terms of sparse domain walls of six flavors. As in the previously studied models, th
Externí odkaz:
http://arxiv.org/abs/2012.09892