FTY720 (Fingolimod) has an antiproliferative effect on human Glioblastoma cells alone and in combination with Temozolomide but does not influence the expression of EMT-related genes

Autor: Gött, H, Nagl, J, Santhiyanesan, S, Seemann, C, Schwarm, FP, Uhl, E, Stein, M, Kolodziej, MA

Publikováno v: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV082 /20220525/

Objective: FTY720 as immunomodulative drug has also an impact on cell signaling pathways involved in cell proliferation and survival, and several studies suggest an effect on epithelial to mesenchymal transition (EMT) pathways. In this study we inves

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