Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Santhi Ganji"'
Autor:
Simon Schenk, Matthew R. Bliss, Thomas D.Y. Chung, Janna Kiselar, Michael P Hedrick, Tomas Mustelin, Laurie A. Bankston, Fusayo Yamamoto, Vida Zhang, Jiwen Zou, Jinghua Yu, Yingge Liu, Stephanie M. Stanford, Andrey A. Bobkov, Robert Ardecky, Nunzio Bottini, Antonio Barquilla, Shilpi Khare, Gregory W. Cadwell, Alexander E. Aleshin, Anthony B. Pinkerton, Santhi Ganji, Robert C. Liddington
Publikováno v:
Nature chemical biology, vol 13, iss 6
Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c1031f609979e1dab8e8a9ec92ae41
https://escholarship.org/uc/item/2ck6d6dq
https://escholarship.org/uc/item/2ck6d6dq
Autor:
John C. Reed, Curt T. Hauser, Marcos González-López, Robert Ardecky, Kate Welsh, Nicholas D. P. Cosford, Hongbin Yuan, Darren Finlay, Trina R. Cooley, Kristiina Vuori, Ying Su, Mitchell Vamos, Santhi Ganji
Publikováno v:
Molecular Cancer Therapeutics. 13:5-15
TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it shows apoptosis-inducing activity in transformed, but not in normal, cells. As with most anticancer agents, however, its clinical use is restricted by either inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf4fab71c8beb7ad98221a86a40df06
https://doi.org/10.1158/1535-7163.mct-13-0153
https://doi.org/10.1158/1535-7163.mct-13-0153
Autor:
John C. Reed, Pooi San Lee, Kate Welsh, Kristiina Vuori, Darren Finlay, Nicholas D. P. Cosford, Palaniyandi Ravanan, Peter D. Mace, Marcos González-López, Robert Ardecky, Stefan J. Riedl, Santhi Ganji
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4253-4257
We recently reported the systematic ligand-based rational design and synthesis of monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Expanded structure–activity relationship (SAR) studies around
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e075e3a02a981d58966e8f4c860597df
https://doi.org/10.1016/j.bmcl.2013.04.096
https://doi.org/10.1016/j.bmcl.2013.04.096
Autor:
José Luis Millán, Pooi San Lee, Colin Farquharson, Nicholas D. P. Cosford, Eduard Sergienko, Raveendra Panickar Dhanya, Layton H. Smith, Peter Teriete, Yalda Bravo, Tina Kiffer-Moreira, Russell Dahl, Santhi Ganji
We report the discovery and characterization of a series of benzoisothiazolone inhibitors of PHOSPHO1, a newly identified soluble phosphatase implicated in skeletal mineralization and soft tissue ossification abnormalities. High-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a28de140d9b826c3f7ff210fda84e1
https://europepmc.org/articles/PMC4170737/
https://europepmc.org/articles/PMC4170737/
Autor:
Russell Dahl, Sonoko Narisawa, Shenghua Shi, Craig Rosenstein, Stefan Vasile, Ying Su, Jiwen Zou, Santhi Ganji, Ian Pass, Anton Cheltsov, Tina Kiffer-Moreira, José Luis Millán, Carlton Gasior, Anthony B. Pinkerton, Flávia Godoy Iano, Brock Brown, Justin Rascon, Jonathan D. Kaunitz, Eduard Sergienko, Marc Hoylaerts, Robert Ardecky, Michael P Hedrick, Thomas D.Y. Chung, Ekaterina V. Bobkova, Anita H. Forster
Publikováno v:
Bioorganic & medicinal chemistry letters, vol 24, iss 3
Alkaline phosphatase (AP) isozymes are present in a wide range of species from bacteria to man and are capable of dephosphorylation and transphosphorylation of a wide spectrum of substrates in vitro. In humans, four AP isozymes have been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f906f998800be90773c889fa8548cab7
https://escholarship.org/uc/item/4131258p
https://escholarship.org/uc/item/4131258p
Autor:
John C. Reed, Scott J. Snipas, Nicholas D. P. Cosford, Mitchell Vamos, Darren Finlay, Monica L. Gonzalez, Guy S. Salvesen, Kate Welsh, Pooi San Lee, Peter D. Mace, Kristiina Vuori, Santhi Ganji, Stefan J. Riedl, Robert Ardecky
A series of novel, potent antagonists of the inhibitor of apoptosis proteins (IAPs) were synthesized in a highly convergent and rapid fashion (≤6 steps) using the Ugi four-component reaction as the key step, thus enabling rapid optimization of bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339df1d3e8e3ef9896e4fd837d1ba780
https://europepmc.org/articles/PMC3953502/
https://europepmc.org/articles/PMC3953502/
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
Autor:
John C. Reed, Kristiina Vuori, Stefan J. Riedl, Richard A. Houghten, Kate Welsh, Marcos González-López, Robert Ardecky, Darren Finlay, Shu-ichi Matsuzawa, Peter Teriete, Santhi Ganji, Nicholas D. P. Cosford, Clemencia Pinilla, Snezana Milutinovic
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0161952 (2016)
PLoS ONE, Vol 11, Iss 9, p e0161952 (2016)
Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (TNF) superfamily cytokines. Most IAPs are opposed endogenously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b513bd38bcd87f3021c0f71770d683
https://doi.org/10.1371/journal.pone.0161952
https://doi.org/10.1371/journal.pone.0161952
Autor:
Kristiina Vuori, Peter Teriete, John C. Reed, Nicholas D. P. Cosford, Kate Welsh, Marcos González-López, Stefan J. Riedl, Hongbin Yuan, Robert Ardecky, Peter D. Mace, Santhi Ganji, Ying Su, Darren Finlay
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(14)
We report the systematic rational design and synthesis of new monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Characterization of compounds in vitro (including 9i; ML101) led to the determinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4a98e14aa3b9d7bf6ccdce48f66c5d
https://pubmed.ncbi.nlm.nih.gov/21680182
https://pubmed.ncbi.nlm.nih.gov/21680182