Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Santhi, Gorantla"'
Autor:
Lauren A. Buck, Qiaowei Xie, Michelle Willis, Christine M. Side, Laura L. Giacometti, Peter J. Gaskill, Kyewon Park, Farida Shaheen, Lili Guo, Santhi Gorantla, Jacqueline M. Barker
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Substance use disorders (SUDs) are highly comorbid with HIV infection, necessitating an understanding of the interactive effects of drug exposure and HIV. The relationship between HIV infection and cocaine use disorder is likely bidirectiona
Externí odkaz:
https://doaj.org/article/1a55c42adb0745c382bf41e89a1e166d
Autor:
Chen Zhang, Hang Su, Emiko Waight, Larisa Y. Poluektova, Santhi Gorantla, Howard E. Gendelman, Prasanta K. Dash
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 149 (2024)
Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been reported that a
Externí odkaz:
https://doaj.org/article/969744862a8b47bf8345d2a165db9cb3
Autor:
Prasanta K. Dash, Santhi Gorantla, Larisa Poluektova, Mahmudul Hasan, Emiko Waight, Chen Zhang, Milica Markovic, Benson Edagwa, Jatin Machhi, Katherine E. Olson, Xinglong Wang, R. Lee Mosley, Bhavesh Kevadiya, Howard E. Gendelman
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Humanized mice model human disease and as such are used commonly for research studies of infectious, degenerative and cancer disorders. Recent models also reflect hematopoiesis, natural immunity, neurobiology, and molecular pathways that inf
Externí odkaz:
https://doaj.org/article/46c593d596184bbc8124e681560d5034
Autor:
Chen Zhang, Lubaba A. Zaman, Larisa Y. Poluektova, Santhi Gorantla, Howard E. Gendelman, Prasanta K. Dash
Publikováno v:
Pathogens, Vol 12, Iss 7, p 879 (2023)
A major roadblock to achieving a cure for human immunodeficiency virus type one (HIV-1) is the persistence of latent viral infections in the cells and tissue compartments of an infected human host. Latent HIV-1 proviral DNA persists in resting memory
Externí odkaz:
https://doaj.org/article/9d154a56697048e6800e5a50d32b9c81
Autor:
Srinivas Chava, C. Patrick Reynolds, Anup S. Pathania, Santhi Gorantla, Larisa Y. Poluektova, Don W. Coulter, Subash C. Gupta, Manoj K. Pandey, Kishore B. Challagundla
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 180-196 (2020)
Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite current aggressive treatment regimens, the prognosis for high‐risk NB patients remains poor, with the survival of less than 40%. Amplification/stabilization of
Externí odkaz:
https://doaj.org/article/d123863f70384ad887db192bc2a7c795
Autor:
Prasanta K. Dash, Fadhel A. Alomar, Jesse L. Cox, JoEllyn McMillan, Bryan T. Hackfort, Edward Makarov, Brenda Morsey, Howard S. Fox, Howard E. Gendelman, Santhi Gorantla, Keshore R. Bidasee
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Early-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herein NOD.Cg-Pr
Externí odkaz:
https://doaj.org/article/4f2a27b9809f46c2b078238674c554a2
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/601ba42884194b299b08e7450ef2a351
Autor:
Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha M. Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won-Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o
Externí odkaz:
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Raghupathy Vengoji, Muzafar A. Macha, Rama Krishna Nimmakayala, Satyanarayana Rachagani, Jawed A. Siddiqui, Kavita Mallya, Santhi Gorantla, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra, Nicole Shonka
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)
Abstract Background Glioblastoma (GBM) is an aggressive brain tumor with universal recurrence and poor prognosis. The recurrence is largely driven by chemoradiation resistant cancer stem cells (CSCs). Epidermal growth factor receptor (EGFR) and its m
Externí odkaz:
https://doaj.org/article/00e5ea5617f04ca8bff2f16fb4dd63f2
Autor:
Saumi Mathews, Amanda Branch Woods, Ikumi Katano, Edward Makarov, Midhun B. Thomas, Howard E. Gendelman, Larisa Y. Poluektova, Mamoru Ito, Santhi Gorantla
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-15 (2019)
Abstract Background Microglia are the principal innate immune defense cells of the centeral nervous system (CNS) and the target of the human immunodeficiency virus type one (HIV-1). A complete understanding of human microglial biology and function re
Externí odkaz:
https://doaj.org/article/f493039c94474631b988061eda271b05