Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Santhakumar Manicassamy"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector func
Externí odkaz:
https://doaj.org/article/ffaacd0e261f464d9be0c36cf7942ac0
Autor:
Olivia A Vogel, Julianna Han, Chieh-Yu Liang, Santhakumar Manicassamy, Jasmine T Perez, Balaji Manicassamy
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008842 (2020)
Signaling through retinoic acid inducible gene I (RIG-I) like receptors (RLRs) is tightly regulated, with activation occurring upon sensing of viral nucleic acids, and suppression mediated by negative regulators. Under homeostatic conditions aberrant
Externí odkaz:
https://doaj.org/article/eab571da46374d9e900b7341be5d8b22
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DCs) control the strength and quality of antigen-specific adaptive immune responses. This is critical for launching a robust immunity against invading pathogens while maintaining a state of tolerance to self-antigens. However, this a
Externí odkaz:
https://doaj.org/article/0c6681e891d44174af7372c6cc9551f3
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway critical for several biological processes. An aberrant Wnt/β-catenin signaling is linked to several human diseases. Emerging studies have highlighted the regulatory role of
Externí odkaz:
https://doaj.org/article/f5892743975d4a4ea0560d6babb20f2e
Autor:
Matheswaran Kandasamy, Amol Suryawanshi, Smanla Tundup, Jasmine T Perez, Mirco Schmolke, Santhakumar Manicassamy, Balaji Manicassamy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005754 (2016)
Retinoic acid inducible gene-I (RIG-I) is an innate RNA sensor that recognizes the influenza A virus (IAV) RNA genome and activates antiviral host responses. Here, we demonstrate that RIG-I signaling plays a crucial role in restricting IAV tropism an
Externí odkaz:
https://doaj.org/article/847215f233cd4663a1b973a9c87fa811
Autor:
Indumathi Manoharan, Daniel Swafford, Arulkumaran Shanmugam, Nikhil Patel, Puttur D. Prasad, Riyaz Mohamed, Qingqing Wei, Zheng Dong, Muthusamy Thangaraju, Santhakumar Manicassamy
Publikováno v:
The Journal of Immunology. 209:368-378
Extraintestinal manifestations are common in inflammatory bowel disease and involve several organs, including the kidney. However, the mechanisms responsible for renal manifestation in inflammatory bowel disease are not known. In this study, we show
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Bal L. Lokeshwar, Vinata B. Lokeshwar, Puttur D. Prasad, Santhakumar Manicassamy, Nagendra Singh, Hasan Korkaya, Pamela M. Martin, Nikhil Patel, Ravirajsinh N. Jedeja, Pachiappan Arjunan, Sarrah L. Hasanali, Daley S. Morera, Pragya Rajpurohit, Adrienne Lester, Utkarsh Parwal, Kavin Tamizhmani, Sabarish Ramachandran, Allison E. Bridges
DNA damage, induced by either chemical carcinogens or environmental pollutants, plays an important role in the initiation of colorectal cancer. DNA repair processes, however, are involved in both protecting against cancer formation, and also contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cac87d6c2f58e7b2067bca443489ed66
https://doi.org/10.1158/1541-7786.c.6545298.v1
https://doi.org/10.1158/1541-7786.c.6545298.v1
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Bal L. Lokeshwar, Vinata B. Lokeshwar, Puttur D. Prasad, Santhakumar Manicassamy, Nagendra Singh, Hasan Korkaya, Pamela M. Martin, Nikhil Patel, Ravirajsinh N. Jedeja, Pachiappan Arjunan, Sarrah L. Hasanali, Daley S. Morera, Pragya Rajpurohit, Adrienne Lester, Utkarsh Parwal, Kavin Tamizhmani, Sabarish Ramachandran, Allison E. Bridges
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84ea298d279262b5d8b417e4e05225c
https://doi.org/10.1158/1541-7786.22527027.v1
https://doi.org/10.1158/1541-7786.22527027.v1
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Bal L. Lokeshwar, Vinata B. Lokeshwar, Puttur D. Prasad, Santhakumar Manicassamy, Nagendra Singh, Hasan Korkaya, Pamela M. Martin, Nikhil Patel, Ravirajsinh N. Jedeja, Pachiappan Arjunan, Sarrah L. Hasanali, Daley S. Morera, Pragya Rajpurohit, Adrienne Lester, Utkarsh Parwal, Kavin Tamizhmani, Sabarish Ramachandran, Allison E. Bridges
Supplementary Figures and Legends 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fcc9b3167f330e4793c7d87d20d531
https://doi.org/10.1158/1541-7786.22527030
https://doi.org/10.1158/1541-7786.22527030
Autor:
Santhakumar Manicassamy, David H. Munn, Andrew L. Mellor, Balaji Manicassamy, Pandelakis A. Koni, Melinda L. Angus-Hill, Tanmay Majumdar, Amol Suryawanshi, Indumathi Manoharan, Yuan Hong
Supplementary Figure S5. Therapeutic effect of blocking the β-catenin pathway against established tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e0ae62bf243d232f13edcaa45691c
https://doi.org/10.1158/0008-5472.22407522.v1
https://doi.org/10.1158/0008-5472.22407522.v1