Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Santanu Bose"'
Autor:
Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract A growing body of evidence suggests that oxysterols such as 25-hydroxycholesterol (25HC) are biologically active and involved in many physiological and pathological processes. Our previous study demonstrated that 25HC induces an innate immun
Externí odkaz:
https://doaj.org/article/30b27e54f69140f39a4a1fadff107675
Autor:
Kim Chiok, Santanu Bose
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 219-222 (2022)
Respiratory syncytial virus, or RSV, is a leading cause of viral pneumonia and bronchiolitis in children and other susceptible populations. RSV infection dysregulates the immune response leading to exaggerated inflammation in the airway. Among other
Externí odkaz:
https://doaj.org/article/294be2bfb8b746be8bedb9e063e2b76e
Autor:
Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Tanya A. Miura, Lisette A. Maddison, Senthil Natesan, Santanu Bose
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Respiratory Syncytial Virus (RSV) is a non-segmented negative-sense RNA virus belonging to the paramyxovirus family. RSV infects the respiratory tract to cause pneumonia and bronchiolitis in infants, elderly, and immunocompromised patients. Effective
Externí odkaz:
https://doaj.org/article/01cfc0a057b64bceae85084bb13be137
Publikováno v:
Viruses, Vol 15, Iss 3, p 754 (2023)
Critically ill COVID-19 patients display signs of generalized hyperinflammation. Macrophages trigger inflammation to eliminate pathogens and repair tissue, but this process can also lead to hyperinflammation and resulting exaggerated disease. The rol
Externí odkaz:
https://doaj.org/article/3990150756554eab9745a90495448bf8
Autor:
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals. Understanding host-virus interactions is essential for the development of effective inte
Externí odkaz:
https://doaj.org/article/704d278d042044dc80a349c065feb783
Autor:
Swechha M. Pokharel, Niraj K. Shil, Jeevan B. GC, Zachary T. Colburn, Su-Yu Tsai, Jesus A. Segovia, Te-Hung Chang, Smarajit Bandyopadhyay, Senthil Natesan, Jonathan C. R. Jones, Santanu Bose
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an in
Externí odkaz:
https://doaj.org/article/39041573d0274347a3d21da9222a9805
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257576 (2021)
Exaggerated inflammatory response results in pathogenesis of various inflammatory diseases. Tumor Necrosis Factor-alpha (TNF) is a multi-functional pro-inflammatory cytokine regulating a wide spectrum of physiological, biological, and cellular proces
Externí odkaz:
https://doaj.org/article/665937c4076d4c1cbea27137c547987b
Autor:
Nicholas M Negretti, Yinyin Ye, Lais M Malavasi, Swechha M Pokharel, Steven Huynh, Susan Noh, Cassidy L Klima, Christopher R Gourley, Claude A Ragle, Santanu Bose, Torey Looft, Craig T Parker, Geremy Clair, Joshua N Adkins, Michael E Konkel
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
The symptoms of infectious diarrheal disease are mediated by a combination of a pathogen’s virulence factors and the host immune system. Campylobacter jejuni is the leading bacterial cause of diarrhea worldwide due to its near-ubiquitous zoonotic a
Externí odkaz:
https://doaj.org/article/514f03e05aba4a3b83309a0d4398f590
Autor:
Lori Bedient, Swechha Mainali Pokharel, Kim R. Chiok, Indira Mohanty, Sierra S. Beach, Tanya A. Miura, Santanu Bose
Publikováno v:
Viruses, Vol 12, Iss 9, p 932 (2020)
Human respiratory syncytial virus (RSV) is the most common cause of viral bronchiolitis and pneumonia in infants and children worldwide. Inflammation induced by RSV infection is responsible for its hallmark manifestation of bronchiolitis and pneumoni
Externí odkaz:
https://doaj.org/article/c1ca0ec07576409fa7b3a7fecca77471
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
Human respiratory syncytial virus (RSV) is a lung tropic virus causing severe airway diseases including bronchiolitis and pneumonia among infants, children and immuno-compromised individuals. RSV triggers transforming growth factor-beta(TGF-beta)
Externí odkaz:
https://doaj.org/article/6fb9727e2afb4263a6ba7ddffcf184de