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Lymphotoxin limits Foxp3 ⁺ regulatory T cell development from Foxp3 ^lo precursors via IL-4 signaling.

Autor: Borelli A; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France., Santamaria JC; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France., Zamit C; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France., Apert C; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291-CNRS UMR5051-University Toulouse III, Toulouse, France.; Microenvironment & Immunity Unit, Institut Pasteur, Paris, France., Chevallier J; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France., Pierre P; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France., Argüello RJ; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France., Spinelli L; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France., Irla M; Aix-Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Centre for Living Systems, Marseille, France. Magali.Irla@inserm.fr.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 14; Vol. 15 (1), pp. 6976. Date of Electronic Publication: 2024 Aug 14.

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4 ⁺ Foxp3 ⁺ regulatory T lymphocytes.

Autor: Apert C; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Galindo-Albarrán AO; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France.; Station d'Ecologie Théorique et Expérimentale, CNRS, Moulis, France., Castan S; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Detraves C; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Michaud H; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., McJannett N; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Haegeman B; Station d'Ecologie Théorique et Expérimentale, CNRS, Moulis, France., Fillatreau S; Institut Necker Enfants Malades, Inserm U1151, CNRS UMR8253, Paris, France.; Université de Paris Descartes, Faculté de Médecine, Paris, France.; AP-HP, Hôpital Necker-Enfants Malades, Paris, France., Malissen B; Centre d'Immunophénomique (CIPHE), Aix Marseille Université, INSERM, CNRS, Marseille, France., Holländer G; Paediatric Immunology, Department of Biomedicine, University of Basel and University Children's Hospital Basel, Basel, Switzerland.; Department of Paediatrics and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Žuklys S; Paediatric Immunology, Department of Biomedicine, University of Basel and University Children's Hospital Basel, Basel, Switzerland., Santamaria JC; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Joffre OP; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Romagnoli P; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., van Meerwijk JPM; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Sep 08; Vol. 13, pp. 965303. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022).

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages.

Autor: Lopes N; Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France., Boucherit N; Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France., Santamaria JC; Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France., Provin N; Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Charaix J; Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France., Ferrier P; Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France., Giraud M; Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Irla M; Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.

Publikováno v: ELife [Elife] 2022 Feb 21; Vol. 11. Date of Electronic Publication: 2022 Feb 21.