Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Santa Jeremy Ono"'
Autor:
Chuan Hui Kuo, L. Zheng, Mark S. Blumenkranz, Kei Morohoshi, Hiroyuki Nomoto, Yannis M. Paulus, Santa Jeremy Ono, Daniel Palanker, Alex K. Nugent
Publikováno v:
Ophthalmic Surgery, Lasers and Imaging Retina. 46:362-368
BACKGROUND AND OBJECTIVE: To characterize the cellular, immunological, and inflammatory response to retinal photocoagulation of intense rupture laser lesions as a model of retinal degenerative diseases. MATERIALS AND METHODS: Seven C57BL/6 mice were
Autor:
Santa Jeremy Ono, Chuan-Hui Kuo, Andrea Collins, Robert B. Garoon, Cho Cho Aye, Kei Morohoshi
Publikováno v:
Experimental and Molecular Pathology. 93:408-415
Mast cells play a key role in immunoglobulin E (IgE)-associated allergic disorders; however, the cellular effects of sensitization remain poorly understood. Using gene microarrays and the multiplexing ELISA method, we examined the effects of sensitiz
Autor:
Victor Chong, Alan C. Bird, Kei Morohoshi, Masaharu Ohbayashi, Santa Jeremy Ono, Nishal Patel
Publikováno v:
Experimental and Molecular Pathology. 93:193-199
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrial counties. Recent findings indicate that the autoimmunity is involved in the pathogenesis of the disease. However, there is no autoantibody biomarker a
Publikováno v:
British Journal of Ophthalmology. 96:1132-1136
Background/aims Allergic conjunctivitis is characterised by early-phase clinical symptoms and late-phase inflammation in the conjunctiva. The role of different chemokine receptors in allergic conjunctivitis, especially during the early-phase reaction
Publikováno v:
Experimental and Molecular Pathology. 92:267-274
Mast cell function is a critical component of allergic reactions. Mast cell responses mediated by the high-affinity immunoglobulin E receptor FceRI can be enhanced by co-activation of additional receptors such as CC chemokine receptor 1 (CCR1). To ex
Publikováno v:
British Journal of Ophthalmology. 95:1451-1456
Introduction Perioperative allergic conjunctivitis accelerates the speed of corneal allograft rejection. This study examines the effect of allergic conjunctivitis, with and without dexamethasone treatment, on the early inflammatory response and lymph
Autor:
Dilniya Fattah, Bita Manzouri, Santa Jeremy Ono, Masaharu Ohbayashi, Andrea Leonardi, Daniel F P Larkin
Publikováno v:
British Journal of Ophthalmology. 94:1662-1667
Background Dendritic cells (DCs) are the most potent antigen-presenting cells involved in initiating the immune response, presenting antigens to T cells and leading to T cell proliferation. In an immature state, DCs lack accessory signals required fo
Publikováno v:
International Immunology. 22:113-128
Chemokines play important regulatory roles in immunity, but their contributions to mast cell function remain poorly understood. We examined the effects of FcepsilonRI-chemokine receptor (CCR) 1 co-stimulation on receptor localization and cellular mor
Publikováno v:
Journal of Autoimmunity. 33:247-254
Autoantibody production is associated with a variety of ocular disorders, including autoimmune retinopathy (AIR) and age-related macular degeneration (AMD). A breakdown of immunologic tolerance (ocular immune privilege), including the blood-retinal b
Autor:
Yoshitsugu Inoue, Fu-Tong Liu, Dai Miyazaki, Atsuki Fukushima, Marc E. Rothenberg, Takeshi Tominaga, Takao Nakamura, Masaharu Ohbayashi, Hidemitsu Higashi, Chuan Hui Kuo, Santa Jeremy Ono, Meguru Murata, Shuzo Takeda, Naoki Komatsu, Keiko Yakura
Publikováno v:
International Immunology. 21:187-201
The immune response is regulated, in part, by effector cells whose activation requires multiple signals. For example, T cells require signals emanating from the T cell antigen receptor and co-stimulatory molecules for full activation. Here, we presen