rAAV expressing a COBRA-designed influenza hemagglutinin generates a protective and durable adaptive immune response with a single dose.

Autor: Wiggins KB; St. Jude Graduate School of Biomedical Sciences, Memphis, Tennessee, USA.; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Winston SM; St. Jude Graduate School of Biomedical Sciences, Memphis, Tennessee, USA.; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Reeves IL; St. Jude Graduate School of Biomedical Sciences, Memphis, Tennessee, USA.; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Gaevert J; St. Jude Graduate School of Biomedical Sciences, Memphis, Tennessee, USA.; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Spence Y; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Brimble MA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Livingston B; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Morton CL; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Sant AJ; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA., Ross TM; Department of Infectious Biology, Cleveland Clinic, Cleveland, Ohio, USA.; Cleveland Clinic, Florida Research and Innovation Center, Port St. Lucie, Florida, USA., Davidoff AM; St. Jude Graduate School of Biomedical Sciences, Memphis, Tennessee, USA.; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Schultz-Cherry S; St. Jude Graduate School of Biomedical Sciences, Memphis, Tennessee, USA.; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Publikováno v: Journal of virology [J Virol] 2024 Aug 20; Vol. 98 (8), pp. e0078124. Date of Electronic Publication: 2024 Jul 30.

Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional Diversity Than Conventional Adjuvant Systems.

Autor: White CL; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA., Glover MA; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA., Gandhapudi SK; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky School of Medicine, Lexington, KY 40508, USA., Richards KA; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA., Sant AJ; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.

Publikováno v: Vaccines [Vaccines (Basel)] 2024 Mar 07; Vol. 12 (3). Date of Electronic Publication: 2024 Mar 07.

Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report.

Autor: Cable J; PhD Science Writer, New York, New York, USA., Balachandran S; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA., Daley-Bauer LP; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA., Rustagi A; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, California, USA., Antony F; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA., Frere JJ; East Harlem Health Outreach Partnership; Department of Medical Education; and Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Strampe J; Bioinformatics Program, Boston University and National Emerging Infectious Diseases Laboratories, Boston, Massachusetts, USA., Kedzierska K; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Cannon JL; Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA., McGargill MA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, California, USA., Mettelman RC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Niessl J; Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Briney B; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA., Valkenburg SA; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China., Bloom JD; Basic Sciences Division and Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Department of Microbiology and Department of Genome Sciences, University of Washington, Seattle, Washington, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA., Iketani S; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA., Rappazzo CG; Adimab LLC, Lebanon, New Hampshire, USA., Crooks CM; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Crofts KF; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Pöhlmann S; Infection Biology Unit, German Primate Center and Faculty of Biology and Psychology, University Medical Center Göttingen, Georg-August-University Göttingen, Göttingen, Germany., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Sant AJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Nabel GJ; Modex Therapeutics Inc., an OPKO Health Company, Natick, Massachusetts, USA., Schultz-Cherry S; Department of Laboratory Medicine and Department of Immunology, Yale University School of Medicine, New Haven, Connecticut, USA.

Publikováno v: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2023 Mar; Vol. 1521 (1), pp. 32-45. Date of Electronic Publication: 2023 Jan 30.

The Negative Effect of Preexisting Immunity on Influenza Vaccine Responses Transcends the Impact of Vaccine Formulation Type and Vaccination History.

Autor: Moritzky SA; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA., Richards KA; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA., Glover MA; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Chaves FA; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA., Topham DJ; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA., Branche A; Department of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, New York, USA., Nayak JL; Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Rochester Medical Center, Rochester, New York, USA., Sant AJ; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2023 Feb 01; Vol. 227 (3), pp. 381-390.

Editorial overview: The life and times of peptide-MHC.

Autor: Sant AJ; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave. Box 609, Rochester, NY 14642, USA., Stern LJ; Department of Pathology, UMass Chan Medical School, Worcester, MA 01605, USA; Immunology and Microbiology Program, UMass Chan Medical School, Worcester, MA 01605, USA. Electronic address: lawrence.stern@umassmed.edu.

Publikováno v: Current opinion in immunology [Curr Opin Immunol] 2022 Oct; Vol. 78, pp. 102244. Date of Electronic Publication: 2022 Sep 28.