Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants.

Autor: Ryø LB; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Haslund D; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Rovsing AB; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Pihl R; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Sanrattana W; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Maat S; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Palarasah Y; Department of Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark; Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark., Maas C; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark., Thiel S; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Mikkelsen JG; Department of Biomedicine, Aarhus University, Aarhus, Denmark. Electronic address: giehm@biomed.au.dk.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Nov; Vol. 152 (5), pp. 1218-1236.e9. Date of Electronic Publication: 2023 Jun 09.

A reactive center loop-based prediction platform to enhance the design of therapeutic SERPINs.

Autor: Sanrattana W; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands., Sefiane T; Laboratory for Haemostasis, Inflammation and Thrombosis, INSERM, Unité Mixte de Recherche 1176, Université Paris-Saclay 94276 Le Kremlin-Bicêtre, France., Smits S; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands., van Kleef ND; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands., Fens MH; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584, The Netherlands., Lenting PJ; Laboratory for Haemostasis, Inflammation and Thrombosis, INSERM, Unité Mixte de Recherche 1176, Université Paris-Saclay 94276 Le Kremlin-Bicêtre, France., Maas C; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands., de Maat S; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht 3584, The Netherlands; s.demaat@umcutrecht.nl.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Nov 09; Vol. 118 (45).

The Fibronectin Type II Domain of Factor XII Ensures Zymogen Quiescence.

Autor: Clark CC; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hofman ZLM; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; The Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Sanrattana W; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., den Braven L; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Maat S; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Maas C; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Publikováno v: Thrombosis and haemostasis [Thromb Haemost] 2020 Mar; Vol. 120 (3), pp. 400-411. Date of Electronic Publication: 2020 Jan 15.

A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation.

Autor: Hofman ZLM; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands; Laboratory for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Clark CC; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Sanrattana W; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Nosairi A; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Parr NMJ; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Živkovic M; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Krause K; Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Mahnke NA; Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Scheffel J; Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Hack CE; Laboratory for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Maurer M; Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., de Maat S; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Maas C; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands. Electronic address: cmaas4@umcutrecht.nl.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Jan 10; Vol. 295 (2), pp. 363-374. Date of Electronic Publication: 2019 Nov 26.

Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress.

Autor: Jarisarapurin W; Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Thailand., Sanrattana W; Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.; Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands., Chularojmontri L; Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Khlong Luang, Pathum Thani, Thailand., Kunchana K; Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Thailand., Wattanapitayakul SK; Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Thailand.

Publikováno v: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2019 Jun 20; Vol. 2019, pp. 4912631. Date of Electronic Publication: 2019 Jun 20 (Print Publication: 2019).