Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sanqiang Li"'
Autor:
Xixi Hou, Longfei Mao, Yajie Guo, Lan Wang, Lizeng Peng, Huili Wang, Jianxue Yang, Sanqiang Li, Yue-Ming Li
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract Modification of marketed drugs is an important way to develop drugs because its safety and clinical applicability. Oxygen-nitrogen heterocycles are a class of important active substances discovered in the process of new drug development. Dol
Externí odkaz:
https://doaj.org/article/d66191b3ae3d4647be1e806383cfcfa9
Autor:
Xiaoshuang Wu, Jinghua Heng, Mengxiang Li, Danxia Deng, Bingli Wu, Muting Wang, Sanqiang Li, Shegan Gao, Yijun Qi, Enmin Li
Publikováno v:
MedComm – Oncology, Vol 3, Iss 3, Pp n/a-n/a (2024)
Abstract The relevance of miR‐200 family in the prognosis of digestive system tumors remains controversial. Through a systematic review of the pertinent literature using online databases including PubMed, EMBASE, The Cochrane Library, and Web of Sc
Externí odkaz:
https://doaj.org/article/bd3d90faf3174553b0f43229be2632ca
Publikováno v:
Journal of Physiological Sciences, Vol 74, Iss 1, Pp 1-10 (2024)
Abstract The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups. Liver injury and fibrosis were assessed using h
Externí odkaz:
https://doaj.org/article/43e9b00a03e642b2bceee81cedbfb35a
Publikováno v:
MedComm – Biomaterials and Applications, Vol 2, Iss 4, Pp n/a-n/a (2023)
Abstract The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for
Externí odkaz:
https://doaj.org/article/a79a9809540e4dd9811a01fde1044625
Publikováno v:
Molecules, Vol 29, Iss 4, p 837 (2024)
In this study, 14 structurally novel gefitinib-1,2,3-triazole derivatives were synthesized using a click chemistry approach and characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry (HRMS). Preliminary cell counting kit-8 results sho
Externí odkaz:
https://doaj.org/article/d60f5bbbcfb943da855ee99248707f36
Autor:
Huaxia Xie, Longfei Mao, Gaolu Fan, Ziyuan Wu, Yimian Wang, Xixi Hou, Jiangang Wang, Huili Wang, Ling Liu, Sanqiang Li
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Based on the structure of the anti-HIV drug cabotegravir, we introduced 1,2,3-triazole groups with different substituents to obtain 19 cabotegravir derivatives and tested their activity against HepG2 cells. The proliferation of HepG2 cells was examin
Externí odkaz:
https://doaj.org/article/5612fbc3d50042a395de40ebf7e890f8
Autor:
Yajie Guo, Dan Sang, Bin Guo, Dan Wang, Xinyue Xu, Huili Wang, Cuilan Hou, Longfei Mao, Fang Li, Sanqiang Li
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
In pursuit of discovering novel anticancer agents, we designed and synthesized a series of novel 1,2,3-triazole hybrids based on cabotegravir analogues. These compounds were subjected to initial biological evaluations to assess their anticancer activ
Externí odkaz:
https://doaj.org/article/912eaaa5f7f34d8a871cdc581a076c60
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/2c4a06cfa77d4744840946000ff4acaf
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2859 (2023)
The development of primary liver cancer (PLC) is associated with chronic liver inflammation and the loss of associated tumor suppressor genes, which characterizes inflammation-related tumors. In this study, we aimed to explore the effect of saikosapo
Externí odkaz:
https://doaj.org/article/196360ff06314a709926fed4b21b1b2c
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Poly(rC)-binding proteins (PCBPs), a defined subfamily of RNA binding proteins, are characterized by their high affinity and sequence-specific interaction with poly-cytosine (poly-C). The PCBP family comprises five members, including hnRNP K and PCBP
Externí odkaz:
https://doaj.org/article/4c30ef8cf83341039ea3586de0ff2615