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pro vyhledávání: '"Sanner, Mark"'
Akademický článek
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Autor:
Kristin Kelly, Christopher John Helal, Tate Bonnie Frances, Mavis Diane Adam, Zhijun Kang, Marcia F. Peterson, Thomas G. Gant, Christopher B. Cooper, Michael K. Ahlijanian, Stanley William Kupchinsky, John C. Lucas, Frank S. Menniti, Sanner Mark Allen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5521-5525
High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC50 = ca. 320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a7b171a8387e73aea99641b4e26b53
https://doi.org/10.1016/j.bmcl.2004.09.006
https://doi.org/10.1016/j.bmcl.2004.09.006
Publikováno v:
Current Topics in Medicinal Chemistry. 2:395-415
Neurofibrillary tangles (NFTs) are a distinguishing neuropathological feature found in postmortem brains of Alzheimer s disease (AD) and tauopathy patients. The density of these lesions correlates with severity of AD and their distribution follows a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01eaa040961dc4e19eb2315e1f479f12
https://doi.org/10.2174/1568026024607526
https://doi.org/10.2174/1568026024607526
Autor:
Sanner Mark Allen
Publikováno v:
Expert Opinion on Therapeutic Patents. 8:383-393
The discovery that the atypical antipsychotic clozapine has higher affinity for the dopamine D4 receptor relative to the D2 receptor touched off a search for more potent, highly selective D4 antagonists as a new class of antipsychotics. Many compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a32587b2f0f7c7efdf4064b959111dd
https://doi.org/10.1517/13543776.8.4.383
https://doi.org/10.1517/13543776.8.4.383
Publikováno v:
Psychopharmacology. 135:194-200
Recent evidence suggests that the dopamine D4 receptor may play a role in schizophrenia, and that the atypical properties of the antipsychotic clozapine may be attributable in part to its antagonistic actions at this receptor. In the present study, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe445d6129ec39457894dabb32fe491
https://doi.org/10.1007/s002130050501
https://doi.org/10.1007/s002130050501
Publikováno v:
Current Opinion in Chemical Biology. 2:535-540
The identification of a novel dopamine receptor subtype, referred to as the D4 receptor, which binds the atypical antipsychoti drug clozapine with high potency, has led to the initiation of a drug discovery program that aims to find novel inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45b75b4e8f0f520b24087e458015c7e
https://doi.org/10.1016/s1367-5931(98)80131-2
https://doi.org/10.1016/s1367-5931(98)80131-2
Autor:
Sanner Mark Allen, Robert W. Dugger, Cliff Meltz, Thomas Allen Chappie, Audrey R. Dunaiskis, T. Keltonic, Tom Staigers
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef00302f31fa6120cdd8205177b454c9
https://doi.org/10.1002/chin.199552158
https://doi.org/10.1002/chin.199552158
Autor:
A L A L Et Et, Sanner Mark Allen
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3c9f447b8145a91d585b18571fbaaa
https://doi.org/10.1002/chin.199830180
https://doi.org/10.1002/chin.199830180
Autor:
Christopher J. Schmidt, Sanner Mark Allen, Karen M. Ward, Susan E. Drozda, James J. Valentine, John A. Lowe, Shari L. DeNinno, Don Tunucci, F. David Tingley
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
We describe a novel series of inhibitors of the type 1 glycine transporter (GlyT1) as an approach to relieving the glutamatergic deficit that is thought to underlie schizophrenia. Synthesis and SAR follow-up of a series of octahydro-cyclopenta[c]pyrr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2c52414b50a652ae30f7bab1cd5d4c
https://pubmed.ncbi.nlm.nih.gov/20045321
https://pubmed.ncbi.nlm.nih.gov/20045321
Autor:
Lowe, John A., III, DeNinno, Shari L., Drozda, Susan E., Schmidt, Christopher J., Ward, Karen M., David Tingley, F., III, Sanner, Mark, Tunucci, Don, Valentine, James
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(3):907-911