Intestinal Apc‐inactivation induces HSP25 dependency

Autor: Sanne M van Neerven, Wouter L Smit, Milou S van Driel, Vaishali Kakkar, Nina E de Groot, Lisanne E Nijman, Clara C Elbers, Nicolas Léveillé, Jarom Heijmans, Louis Vermeulen

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-16 (2022)

Abstract The majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC. APC mutations result in oncogenic activation of the Wnt pathway, which is associated with hyperproliferation, cytoskeletal remodeling, and a

Externí odkaz: https://doaj.org/article/891ee3363d044458ba63925b9b465371

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut

Autor: Rana Ramadan, Valérie M. Wouters, Sanne M. van Neerven, Nina E. de Groot, Tania Martins Garcia, Vanessa Muncan, Olivia D. Franklin, Michelle Battle, Karen Sue Carlson, Joshua Leach, Owen J. Sansom, Olivier Boulard, Mathias Chamaillard, Louis Vermeulen, Jan Paul Medema, David J. Huels

Publikováno v: Biology Open, Vol 11, Iss 12 (2022)

Externí odkaz: https://doaj.org/article/ee689493b87c437690668170fbf2c3b2

Intestinal organoid co-culture protocol to study cell competition in vitro

Autor: Sanne M. van Neerven, Rana Ramadan, Milou S. van Driel, David J. Huels, Louis Vermeulen

Publikováno v: STAR Protocols, Vol 3, Iss 1, Pp 101050- (2022)

Summary: Intestinal organoid cultures are a powerful tool to study epithelial cells in vitro, as they are able to proliferate and differentiate into all cell lineages observed in vivo. Co-culturing organoids with distinct genetic backgrounds provides

Externí odkaz: https://doaj.org/article/bdcc04b68bf648edb4770ee43649041c

The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts

Autor: Job Komen, Sanne M. van Neerven, Elsbeth G. B. M. Bossink, Nina E. de Groot, Lisanne E. Nijman, Albert van den Berg, Louis Vermeulen, Andries D. van der Meer

Publikováno v: Micromachines, Vol 13, Iss 5, p 739 (2022)

The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer drugs. However, the model is imperfect; animal models are ethically burdened, and the impe

Externí odkaz: https://doaj.org/article/18db37a0126c41348682c3579ba25ad1

Serum levels of iCAF-derived osteoglycin predict favorable outcome in pancreatic cancer

Autor: Mark P. G. Dings, Paul Manoukian, Cynthia Waasdorp, Judith S. E. Quik, Marin Strijker, Sophie C. Lodestijn, Sanne M. van Neerven, Leandro F. Moreno, Rodrigo Leite de Oliveira, Bert A. Bonsing, Marco J. Bruno, Olivier R. Busch, Michael Doukas, Casper H. van Eijck, Nadia Haj Mohammad, Ignace H. de Hingh, Quintus I. Molenaar, Marc G. Besselink, Louis Vermeulen, Jan Paul Medema, Hanneke W. M. van Laarhoven, Maarten F. Bijlsma

Publikováno v: International Journal of Cancer, 152(3), 511-523. Wiley-Liss Inc.
International Journal of Cancer, 152(3), 511-523. WILEY
Dings, M P G, Manoukian, P, Waasdorp, C, Quik, J S E, Strijker, M, Lodestijn, S C, van Neerven, S M, Moreno, L F, de Oliveira, R L, Bonsing, B A, Bruno, M J, Busch, O R, Doukas, M, van Eijck, C H, Mohammad, N H, de Hingh, I H, Molenaar, Q I, Besselink, M G, Vermeulen, L, Medema, J P, van Laarhoven, H W M & Bijlsma, M F 2023, ' Serum levels of iCAF-derived osteoglycin predict favorable outcome in pancreatic cancer ', International Journal of Cancer, vol. 152, no. 3, pp. 511-523 . https://doi.org/10.1002/ijc.34276

Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma, the main cellular constituents of which are cancer-associated fibroblasts (CAFs). Stroma-targeting agents have been proposed to improve the poor outcome of current treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3cf7b99880ba5044d3e85803aa329b
https://pure.eur.nl/en/publications/4e1ed1ff-157e-4175-868e-0238266dcf34