Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sanne G.S. Verberk"'
Autor:
Jeroen Baardman, Sanne G.S. Verberk, Koen H.M. Prange, Michel van Weeghel, Saskia van der Velden, Dylan G. Ryan, Rob C.I. Wüst, Annette E. Neele, Dave Speijer, Simone W. Denis, Maarten E. Witte, Riekelt H. Houtkooper, Luke A. O’neill, Elena V. Knatko, Albena T. Dinkova-Kostova, Esther Lutgens, Menno P.J. de Winther, Jan Van den Bossche
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Summary: Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of dyslipidemia on immune
Externí odkaz:
https://doaj.org/article/d4969ea3a1584cdbbc7e5b1d85f55612
Autor:
Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Sanne G.S. Verberk, Mansour Haidar, Jerome J.A. Hendriks, Jeroen F.J. Bogie
Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benign effecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b120ea3d280c88a5f9ab4c9c9f6f88
https://doi.org/10.1101/2022.12.23.521775
https://doi.org/10.1101/2022.12.23.521775
Autor:
Felix J. Hartmann, Sanne G.S. Verberk, Dunja Mrdjen, Erin McCaffrey, Sean C. Bendall, David Van Valen, Jan Van den Bossche, Noah F. Greenwald, Alex Baranski, Reema Baskar, David R. Glass, Zumana Khair, Michael Angelo, William Graf, Anusha Bharadwaj
Publikováno v:
Nature Biotechnology, 39(2), 186-197. Nature Publishing Group
Hartmann, F J, Mrdjen, D, McCaffrey, E, Glass, D R, Greenwald, N F, Bharadwaj, A, Khair, Z, Verberk, S G S, Baranski, A, Baskar, R, Graf, W, Van Valen, D, Van den Bossche, J, Angelo, M & Bendall, S C 2021, ' Single-cell metabolic profiling of human cytotoxic T cells ', Nature Biotechnology, vol. 39, no. 2, pp. 186-197 . https://doi.org/10.1038/s41587-020-0651-8
Nature biotechnology
Hartmann, F J, Mrdjen, D, McCaffrey, E, Glass, D R, Greenwald, N F, Bharadwaj, A, Khair, Z, Verberk, S G S, Baranski, A, Baskar, R, Graf, W, Van Valen, D, Van den Bossche, J, Angelo, M & Bendall, S C 2021, ' Single-cell metabolic profiling of human cytotoxic T cells ', Nature Biotechnology, vol. 39, no. 2, pp. 186-197 . https://doi.org/10.1038/s41587-020-0651-8
Nature biotechnology
Cellular metabolism regulates immune cell activation, differentiation and effector functions, but current metabolic approaches lack single-cell resolution and simultaneous characterization of cellular phenotype. In this study, we developed an approac
Autor:
Kyra E. de Goede, Karl J. Harber, Friederike S. Gorki, Sanne G.S. Verberk, Laszlo A. Groh, Eelco D. Keuning, Eduard A. Struys, Michel van Weeghel, Arvand Haschemi, Menno P.J. de Winther, Xanthe A.M.H. van Dierendonck, Jan Van den Bossche
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease, 1868
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(9):166427. Elsevier
de Goede, K E, Harber, K J, Gorki, F S, Verberk, S G S, Groh, L A, Keuning, E D, Struys, E A, van Weeghel, M, Haschemi, A, de Winther, M P J, van Dierendonck, X A M H & van den Bossche, J 2022, ' D-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation ', Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1868, no. 9, 166427 . https://doi.org/10.1016/j.bbadis.2022.166427
Biochimica et biophysica acta. Molecular basis of disease, 1868, 9
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1868(9):166427. Elsevier
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(9):166427. Elsevier
de Goede, K E, Harber, K J, Gorki, F S, Verberk, S G S, Groh, L A, Keuning, E D, Struys, E A, van Weeghel, M, Haschemi, A, de Winther, M P J, van Dierendonck, X A M H & van den Bossche, J 2022, ' D-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation ', Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1868, no. 9, 166427 . https://doi.org/10.1016/j.bbadis.2022.166427
Biochimica et biophysica acta. Molecular basis of disease, 1868, 9
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1868(9):166427. Elsevier
Contains fulltext : 251502.pdf (Publisher’s version ) (Open Access) Macrophages undergo extensive metabolic rewiring upon activation which assist the cell in roles beyond energy production and synthesis of anabolic building blocks. So-called immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c480bd1717fb6bb688024b463114cb
http://hdl.handle.net/2066/251502
http://hdl.handle.net/2066/251502
Publikováno v:
Verberk, S G S, Kuiper, K L, Lauterbach, M A, Latz, E & van den Bossche, J 2021, ' The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis ', Trends in Molecular Medicine, vol. 27, no. 12, pp. 1095-1105 . https://doi.org/10.1016/j.molmed.2021.09.004
ATP-citrate lyase (Acly) is the target of the new class low-density lipoprotein-cholesterol (LDL-C)-lowering drug bempedoic acid (BA). Acly is a key metabolic enzyme synthesizing acetyl-CoA as the building block of cholesterol and fatty acids. Treatm
Autor:
Sanne G.S. Verberk, Jeroen Baardman, Kyra E. de Goede, Jan Van den Bossche, Karl J Harber, Sjoerd T.T. Schetters, Menno P.J. de Winther, Yvette van Kooyk
Publikováno v:
Cancers
Volume 13
Issue 12
Cancers, 13(12):3054. Multidisciplinary Digital Publishing Institute (MDPI)
de Goede, K E, Verberk, S G S, Baardman, J, Harber, K J, van Kooyk, Y, de Winther, M P J, Schetters, S T T & Van den Bossche, J 2021, ' Myeloid-specific acly deletion alters macrophage phenotype in vitro and in vivo without affecting tumor growth ', Cancers, vol. 13, no. 12, 3054 . https://doi.org/10.3390/cancers13123054
Cancers, Vol 13, Iss 3054, p 3054 (2021)
Volume 13
Issue 12
Cancers, 13(12):3054. Multidisciplinary Digital Publishing Institute (MDPI)
de Goede, K E, Verberk, S G S, Baardman, J, Harber, K J, van Kooyk, Y, de Winther, M P J, Schetters, S T T & Van den Bossche, J 2021, ' Myeloid-specific acly deletion alters macrophage phenotype in vitro and in vivo without affecting tumor growth ', Cancers, vol. 13, no. 12, 3054 . https://doi.org/10.3390/cancers13123054
Cancers, Vol 13, Iss 3054, p 3054 (2021)
Simple Summary Tumor cells show different metabolism compared to normal tissue. For instance, they increase ATP-citrate lyase (Acly) expression for increased proliferation. Acly is therefore currently being targeted for cancer therapy. However, targe
Autor:
Judith C. Sluimer, Michel van Weeghel, Helga E. de Vries, Sanne G.S. Verberk, Soufyan Lakbir, Koen H.M. Prange, Marion J.J. Gijbels, Gijs Kooij, Saskia van der Velden, Menno P.J. de Winther, Cindy P. P. A. van Roomen, Guillermo R. Griffith, Douwe Molenaar, Jan Van den Bossche, Jelle Y. Broos, Elisa Meinster, Esther Lutgens, Jeroen Baardman, Annette E. Neele, Kathryn E. Wellen
Publikováno v:
Baardman, J, Verberk, S G S, van der Velden, S, Gijbels, M J J, van Roomen, C P P A, Sluimer, J C, Broos, J Y, Griffith, G R, Prange, K H M, van Weeghel, M, Lakbir, S, Molenaar, D, Meinster, E, Neele, A E, Kooij, G, de Vries, H E, Lutgens, E, Wellen, K E, de Winther, M P J & Van den Bossche, J 2020, ' Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques ', Nature Communications, vol. 11, no. 1, 6296 . https://doi.org/10.1038/s41467-020-20141-z
Nature Communications
Nature Communications, 11(1):6296. Nature Publishing Group UK
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1):6296. Nature Publishing Group
Nature communications, 11(1):6296. Nature Publishing Group
Nature Communications
Nature Communications, 11(1):6296. Nature Publishing Group UK
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1):6296. Nature Publishing Group
Nature communications, 11(1):6296. Nature Publishing Group
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrop
Autor:
Sanne G.S. Verberk, Reina E. Mebius, Tanja Konijn, Jan Van den Bossche, Marieke R. Beijer, Joke M. M. den Haan, Gera Goverse, Kyra E. de Goede, Martje N. Erkelens, Rosalie Molenaar, Wouter J. de Jonge
Publikováno v:
Erkelens, M N, Goverse, G, Konijn, T, Molenaar, R, Beijer, M R, Van den Bossche, J, de Goede, K E, Verberk, S G S, de Jonge, W J, den Haan, J M M & Mebius, R E 2020, ' Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling ', Frontiers in Immunology, vol. 11, 551 . https://doi.org/10.3389/fimmu.2020.00551
Frontiers in Immunology
Frontiers in Immunology, 11:551
Frontiers in immunology, 11:551. Frontiers Media S.A.
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology, 11:551
Frontiers in immunology, 11:551. Frontiers Media S.A.
Frontiers in Immunology, Vol 11 (2020)
Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation, allowing symbiotic co-existence with the intestinal microbiota. However, upon acute events suc
Autor:
Jan Aten, Liffert Vogt, Jeroen Baardman, Jan Van den Bossche, Jeffrey Kroon, Esmee M. Schrooten, Emma Rademaker, Annette E. Neele, Nike Claessen, Sanne G.S. Verberk, Eliane F. E. Wenstedt, Rosa D. Wouda, Özge T. Pasaoglu, Menno P.J. de Winther
Publikováno v:
JCI insight, 4(21):e130508. The American Society for Clinical Investigation
Wenstedt, E F, Verberk, S G, Kroon, J, Neele, A E, Baardman, J, Claessen, N, Pasaoglu, O T, Rademaker, E, Schrooten, E M, Wouda, R D, de Winther, M P, Aten, J, Vogt, L & Van den Bossche, J 2019, ' Salt increases monocyte CCR2 expression and inflammatory responses in humans. ', JCI Insight, vol. 4, no. 21 . https://doi.org/10.1172/jci.insight.130508
JCI Insight, 4(21). The American Society for Clinical Investigation
Wenstedt, E F, Verberk, S G, Kroon, J, Neele, A E, Baardman, J, Claessen, N, Pasaoglu, O T, Rademaker, E, Schrooten, E M, Wouda, R D, de Winther, M P, Aten, J, Vogt, L & Van den Bossche, J 2019, ' Salt increases monocyte CCR2 expression and inflammatory responses in humans. ', JCI Insight, vol. 4, no. 21 . https://doi.org/10.1172/jci.insight.130508
JCI Insight, 4(21). The American Society for Clinical Investigation
Inflammation may play a role in the link between high salt intake and its deleterious consequences. However, it is unknown whether salt can induce proinflammatory priming of monocytes and macrophages in humans. We investigated the effects of salt on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a0a013adb5ed96ddb014072617d817
https://pure.amc.nl/en/publications/salt-increases-monocyte-ccr2-expression-and-inflammatory-responses-in-humans(c56466d4-df0a-422e-a8a3-cb2e3f8374d4).html
https://pure.amc.nl/en/publications/salt-increases-monocyte-ccr2-expression-and-inflammatory-responses-in-humans(c56466d4-df0a-422e-a8a3-cb2e3f8374d4).html
Publikováno v:
Epigenomics, 11(7), 719-721. Future Medicine Ltd.
Verberk, S G S, De Goede, K E & Van Den Bossche, J 2019, ' Metabolic-epigenetic crosstalk in macrophage activation : An updated view ', Epigenomics, vol. 11, no. 7, pp. 719-721 . https://doi.org/10.2217/epi-2019-0073
Verberk, S G S, De Goede, K E & Van Den Bossche, J 2019, ' Metabolic-epigenetic crosstalk in macrophage activation : An updated view ', Epigenomics, vol. 11, no. 7, pp. 719-721 . https://doi.org/10.2217/epi-2019-0073
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac1be6fc251e9d64ed1e8376f2fcdfb
https://research.vumc.nl/en/publications/eaf2d492-b0b7-4964-aa7b-0ea7333ade4a
https://research.vumc.nl/en/publications/eaf2d492-b0b7-4964-aa7b-0ea7333ade4a