Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sanne D. van Otterdijk"'
Publikováno v:
Epigenetics, Vol 12, Iss 10, Pp 875-885 (2017)
We investigated the impact of maternal smoking during pregnancy on placental DNA methylation and how this may mediate the association between maternal smoking and pro-inflammatory proteins in cord blood. The study population consisted of 27 individua
Externí odkaz:
https://doaj.org/article/344826d21d1f4a419b1788498846ec4e
Autor:
Shabnam H. Thathia, Stuart Ferguson, Hannah E. Gautrey, Sanne D. van Otterdijk, Michela Hili, Vikki Rand, Anthony V. Moorman, Stefan Meyer, Robert Brown, Gordon Strathdee
Publikováno v:
Haematologica, Vol 97, Iss 3 (2012)
Background Altered regulation of many transcription factors has been shown to be important in the development of leukemia. TWIST2 modulates the activity of a number of important transcription factors and is known to be a regulator of hematopoietic di
Externí odkaz:
https://doaj.org/article/a7083f00771a402da76cdb7aa4e9568f
Autor:
Alexandra M Binder, Leah T Stiemsma, Kristen Keller, Sanne D van Otterdijk, Verónica Mericq, Ana Pereira, José L Santos, John Shepherd, Karin B Michels
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The influence of epigenetic regulation of ER-α on adolescent breast composition h
Externí odkaz:
https://doaj.org/article/a2f803dfab9e450487fc62b7d64de388
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 37(1)
Folate plays an important role in the modulation of one-carbon metabolism and DNA methylation through a complex biosynthesis pathway. Folate deficiency during pregnancy has been associated with an increased risk for birth defects. This study investig
Autor:
Sanne D van Otterdijk, Alexandra M Binder, Katarzyna Szarc Vel Szic, Julia Schwald, Karin B Michels
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180955 (2017)
The prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is increasing and several studies suggested an involvement of DNA methylation in the development of these metabolic diseases. This study was designed to investigate if differen
Externí odkaz:
https://doaj.org/article/300b571e821945d29f6c2c7fd2608c84
Publikováno v:
Epigenetics. 12:875-885
We investigated the impact of maternal smoking during pregnancy on placental DNA methylation and how this may mediate the association between maternal smoking and pro-inflammatory proteins in cord blood. The study population consisted of 27 individua
Autor:
Karin B. Michels, José Luis Santos, Verónica Mericq, Kristen Keller, Leah T. Stiemsma, Sanne D. van Otterdijk, John A. Shepherd, Alexandra M. Binder, Ana Pereira
Publikováno v:
Clinical Epigenetics
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Clinical epigenetics, vol 10, iss 1
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Clinical epigenetics, vol 10, iss 1
Background Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The influence of epigenetic regulation of ER-α on adolescent breast composition has not be
Autor:
Julia Schwald, Alexandra M. Binder, Karin B. Michels, Sanne D. van Otterdijk, Katarzyna Szarc vel Szic
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180955 (2017)
PloS one, vol 12, iss 7
PLoS ONE
PloS one, vol 12, iss 7
PLoS ONE
Author(s): van Otterdijk, Sanne D; Binder, Alexandra M; Szarc Vel Szic, Katarzyna; Schwald, Julia; Michels, Karin B | Abstract: IntroductionThe prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is increasing and several studies su
Autor:
Gordon Strathdee, John C. Mathers, Newcastle + Study Core Team, Hannah E. Gautrey, Sanne D. van Otterdijk, Heather J. Cordell
Publikováno v:
The FASEB Journal. 28:3261-3272
Abnormal patterns of DNA methylation are one of the hallmarks of cancer cells. The process of aging has also been associated with similar, albeit less dramatic, changes in methylation patterns, leading to the hypothesis that age-related changes in DN
Autor:
Kenrick Serbonij, Herman E. Popeijus, Sophie E. van der Krieken, Maurice C. J. M. Konings, Ronald P. Mensink, Sanne D. van Otterdijk, Jogchum Plat
Publikováno v:
Molecular Nutrition & Food Research, 58(12), 2342-2349. Wiley
SCOPE:: Fatty acids regulate PPARalpha activity, however, most studies evaluated the binding ability of fatty acids to PPARalpha, which does not necessarily results in PPARalpha transactivation. We therefore examined dose-response relationships betwe