Hypothermic oxygenated machine perfusion prevents arteriolonecrosis of the peribiliary plexus in pig livers donated after circulatory death.

Autor: Sanna Op den Dries, Michael E Sutton, Negin Karimian, Marieke T de Boer, Janneke Wiersema-Buist, Annette S H Gouw, Henri G D Leuvenink, Ton Lisman, Robert J Porte

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88521 (2014)

BackgroundLivers derived from donation after circulatory death (DCD) are increasingly accepted for transplantation. However, DCD livers suffer additional donor warm ischemia, leading to biliary injury and more biliary complications after transplantat

Externí odkaz: https://doaj.org/article/1a09abd2dc114c9bbdc64c54b8e5a6d5

Normothermic Machine Perfusion Reduces Bile Duct Injury and Improves Biliary Epithelial Function in Rat Donor Livers

Autor: Negin Karimian, Andrie C. Westerkamp, Ben N G Giepmans, Petra J. Ottens, Jeroen Kuipers, Robert J. Porte, Henri G. D. Leuvenink, Michael E. Sutton, Ton Lisman, Janneke Wiersema-Buist, Michiel Kuipers, Sanna op den Dries

Publikováno v: Liver Transplantation, 22(7), 994-1005. Wiley

BACKGROUND: Bile duct injury may occur during liver procurement and transplantation, especially in livers donated after circulatory death (DCD). Normothermic machine perfusion (NMP) has been shown to reduce hepatic injury, compared to static cold sto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45aa2c62ce8fe0bef616dc8a850c68c
https://research.rug.nl/en/publications/f2d15826-be22-4ea5-8e05-67bc37da87cc

Activation of Fibrinolysis, But Not Coagulation, During End-Ischemic Ex Situ Normothermic Machine Perfusion of Human Donor Livers

Autor: Ton Lisman, Robert J. Porte, Michael E. Sutton, Rianne van Rijn, Sanna op den Dries, Shanice A. Karangwa, Janneke Wiersema-Buist, Negin Karimian, Andrie C. Westerkamp, Alix P M Matton, Jelle Adelmeijer, Laura C. Burlage

Publikováno v: Transplantation, 101(2), E42-E48. LIPPINCOTT WILLIAMS & WILKINS

BACKGROUND Ex situ normothermic machine perfusion (NMP) can be performed after traditional static cold preservation to assess graft function and viability before transplantation. It is unknown whether this results in activation of coagulation and fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f5df478a20a6b7073815f4f7503c05
https://research.rug.nl/en/publications/b058f073-cd6a-46e6-a632-f40fca9aaf8c

Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures

Autor: Sanna op den Dries, James F. Markmann, Korkut Uygun, Ton Lisman, Paulo N. Martins, Negin Karimian, Annette S. H. Gouw, Andrie C. Westerkamp, Bote G. Bruinsma, Robert J. Porte, Heidi Yeh

Publikováno v: Transplantation, 98, 175-175. LIPPINCOTT WILLIAMS & WILKINS
American Journal of Transplantation, 14, 175-175. Wiley
Journal of Hepatology, 60(6), 1172-1179. ELSEVIER SCIENCE BV

Background & Aims: The peribiliary glands of large bile ducts have been identified as a niche of progenitor cells that contribute to regeneration of biliary epithelium after injury. We aimed to determine whether injury to the peribiliary glands of do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bc4807c06c634d31972c5eccacb8c0
https://doi.org/10.1016/j.jhep.2014.02.010

Protection of Bile Ducts in Liver Transplantation

Autor: Ton Lisman, Sanna op den Dries, Michael E. Sutton, Robert J. Porte

Publikováno v: Transplantation, 92(4), 373-379. LIPPINCOTT WILLIAMS & WILKINS

Biliary complications, especially nonanastomotic biliary strictures (NAS), are a major cause of morbidity after orthotopic liver transplantation. Of all donor and recipient characteristics known to increase the risk of developing NAS, the role of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41b086abef6706df90189c05ade8d0d
https://doi.org/10.1097/tp.0b013e318223a384