Výsledky vyhledávání - "Sanna Vattulainen"

Akademický článek

FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells.

Autor: Mikko Anttonen, Marjut Pihlajoki, Noora Andersson, Adrien Georges, David L'hôte, Sanna Vattulainen, Anniina Färkkilä, Leila Unkila-Kallio, Reiner A Veitia, Markku Heikinheimo

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85545 (2014)

Aberrant ovarian granulosa cell proliferation and apoptosis may lead to granulosa cell tumors (GCT), the pathogenesis of which involves transcription factors GATA4, FOXL2, and SMAD3. FOXL2 gene harbors a point mutation (C134W) in a vast majority of G

Externí odkaz: https://doaj.org/article/94e0c06cb7f5423a9c8c35a81bd5320b

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Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells

Autor: Nicholas W. Morrell, Mark Southwood, Stephen Moore, Xudong Yang, Sanna Vattulainen-Collanus, Giorgio Lagna, Akiko Hata, Prajakta Ghatpande

Publikováno v: Communications biology, vol 1, iss 1
Vattulainen-Collanus, Sanna; Southwood, Mark; Yang, Xu Dong; Moore, Stephen; Ghatpande, Prajakta; Morrell, Nicholas W; et al.(2018). Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.. Communications biology, 1(1), 149. doi: 10.1038/s42003-018-0152-1. UCSF: Retrieved from: http://www.escholarship.org/uc/item/90t429nn
Communications Biology, Vol 1, Iss 1, Pp 1-15 (2018)

The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a7f399de677982be2f1e75a5b2e5a4
https://doi.org/10.1038/s42003-018-0152-1

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Genetics and genotype–phenotype correlations in Finnish patients with dilated cardiomyopathy

Autor: Jonna Tallila, Massimiliano Gentile, Samuel Myllykangas, Maija Kaartinen, Pertteli Salmenperä, Sanna Vattulainen, Tero-Pekka Alastalo, Laura Ollila, Hannele Koillinen, Juha Koskenvuo, Tiina Heliö, Oyediran Akinrinade, Markku S. Nieminen

Publikováno v: European Heart Journal

Genetic analysis among patients with dilated cardiomyopathy (DCM) is becoming an important part of clinical assessment, as it is in hypertrophic cardiomyopathy (HCM). The genetics of DCM is complex and therefore next-generation sequencing strategies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e498a0b9a09312ffc8aa515446be8bf7
http://europepmc.org/articles/PMC4561350

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Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension

Autor: Joonas Aho, Lingli Wang, Pekka Taimen, Sanna Vattulainen, Tero-Pekka Alastalo, Juha Koskenvuo, Vinicio A. de Jesus Perez, Anne Komulainen, Mikko Helenius, Mark Orcholski

Publikováno v: AJP - Lung Cellular and Molecular Physiology. 308(10):L1046-L1057

Endothelial cell (EC) dysfunction plays a role in the pathobiology of occlusive vasculopathy in pulmonary arterial hypertension (PAH). Purinergic signaling pathways, which consist of extracellular nucleotide and nucleoside-mediated cell signaling thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a9190932b68ae14bd36e8bb4a2ceba
https://doi.org/10.1152/ajplung.00340.2014

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Loss of Bone Morphogenetic Protein Receptor 2 Is Associated with Abnormal DNA Repair in Pulmonary Arterial Hypertension

Autor: Tero-Pekka Alastalo, Vinicio A. de Jesus Perez, Samuel Myllykangas, Mark Orcholski, Molong Li, Pekka Taimen, Ke Yuan, Joonas Aho, Sanna Vattulainen, Mikko Helenius, Vanessa Rojas, Juha Koskenvuo

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 50:1118-1128

Occlusive vasculopathy with intimal hyperplasia and plexogenic arteriopathy are severe histopathological changes characteristic of pulmonary arterial hypertension (PAH). Although a phenotypic switch in pulmonary endothelial cells (ECs) has been sugge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20262812cd4e94a03e64641ae6106a85
https://doi.org/10.1165/rcmb.2013-0349oc

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Extracellular ATP protects endothelial cells against DNA damage

Autor: Joonas Aho, Sanna Vattulainen-Collanus, Juha Koskenvuo, Tero-Pekka Alastalo, Mikko Helenius

Cell damage can lead to rapid release of ATP to extracellular space resulting in dramatic change in local ATP concentration. Evolutionary, this has been considered as a danger signal leading to adaptive responses in adjacent cells. Our aim was to dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a944f60331fd94b231e5267eed00c3
http://hdl.handle.net/10138/228253

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Loss of PPARγ in endothelial cells leads to impaired angiogenesis

Autor: Marlene Rabinovitch, Shailaja P. Rao, Minna Koskenvuo, Molong Li, Cristina M. Alvira, Ke Yuan, Hirofumi Sawada, Tero-Pekka Alastalo, Juha Koskenvuo, Sanna Vattulainen-Collanus, Oyediran Akinrinade, Vinicio A. de Jesus Perez, Caiyun G. Li

Publikováno v: Journal of cell science. 129(4)

Tie2-promoter-mediated loss of peroxisome proliferator-activated receptor gamma (PPARγ, also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension. Vascular disease is associated with loss of PPARγ in pulmonary microvas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400a4ea544a9101d353611d1b2b58ccd
https://pubmed.ncbi.nlm.nih.gov/26743080

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Accurate genetic diagnosis of Finnish pulmonary arterial hypertension patients using oligonucleotide-selective sequencing

Autor: Marja Sankelo, Tarja Laitinen, Siina Bruce, Juha Koskenvuo, Massimiliano Gentile, Jonna Tallila, Pertteli Salmenperä, Tero-Pekka Alastalo, Joonas Aho, Sanna Vattulainen, Samuel Myllykangas

Publikováno v: Molecular Genetics & Genomic Medicine

The genetic basis of pulmonary arterial hypertension (PAH) among Finnish PAH patients is poorly understood. We adopted a novel-targeted next-generation sequencing (NGS) approach called Oligonucleotide-Selective Sequencing (OS-Seq) and developed a cus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9bc9889786efe6115bb95b2fbd9251
http://hdl.handle.net/10138/233220

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FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells

Autor: Sanna Vattulainen, Anniina Färkkilä, Leila Unkila-Kallio, Adrien Georges, Marjut Pihlajoki, Noora Andersson, Markku Heikinheimo, Mikko Anttonen, David L'Hôte, Reiner A. Veitia

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e85545. ⟨10.1371/journal.pone.0085545⟩
PLoS ONE, Vol 9, Iss 1, p e85545 (2014)

International audience; Aberrant ovarian granulosa cell proliferation and apoptosis may lead to granulosa cell tumors (GCT), the pathogenesis of which involves transcription factors GATA4, FOXL2, and SMAD3. FOXL2 gene harbors a point mutation (C134W)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff91c823691f31016c8fb0551357ef3
https://hal.archives-ouvertes.fr/hal-00951280

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