Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Sanna M Goyert"'
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Akademický článek
Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis.
Autor: Michael Miksa, Padmalaya Das, Mian Zhou, Rongqian Wu, Weifeng Dong, Youxin Ji, Sanna M Goyert, Thanjavur S Ravikumar, Ping Wang
Publikováno v: PLoS ONE, Vol 4, Iss 5, p e5504 (2009)
BACKGROUND:Norepinephrine (NE) modulates the responsiveness of macrophages to proinflammatory stimuli through the activation of adrenergic receptors (ARs). Being part of the stress response, early increases of NE in sepsis sustain adverse systemic in
Externí odkaz: https://doaj.org/article/3a8595c84d99409185d910bb913c1390
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3
Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans
Autor: Ekaterina A. Pechenkina, Sanna M. Goyert, Jack Silver, Jessica F. Brinkworth
Publikováno v: Journal of Medical Primatology. 41:388-393
As African catarrhines, the common chimpanzee (Pan troglodytes) and baboon (Papio sp.) share 98.6% and 94% of their genomes, respectively, with humans and are considered important models of human infectious disease [4, 6, 20]. However, these species
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86b34fa171107a5c1fdb3e67cbf646f
https://doi.org/10.1111/jmp.12002
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4
Differential expression of CD14-dependent and independent pathways for chemokine induction regulates neutrophil trafficking in infection
Autor: Sanna M. Goyert, Jack Silver, Kwang Sik Kim, Shalaka Metkar
Publikováno v: Journal of Leukocyte Biology. 92:389-396
Harnessing the CD14-independent pathway for chemokine induction in severe infection leads to early neutrophil recruitment to the site of infection, enhanced bacterial clearance, and survival. Previous studies have shown that CD14−/− mice are resi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc84190939c985655dc00553896a743
https://doi.org/10.1189/jlb.0112011
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5
Milk Fat Globule Epidermal Growth Factor-Factor VIII Is Down-Regulated in Sepsis via the Lipopolysaccharide-CD14 Pathway
Autor: Sanna M. Goyert, Rongqian Wu, Michael Miksa, Ping Wang, Hidefumi Komura
Publikováno v: Scopus-Elsevier
ResearcherID
Phagocytosis prevents the release of potentially harmful or immunogenic materials from dying cells. Milk fat globule epidermal growth factor (EGF)-factor VIII (MFG-E8) mediates the clearance of apoptotic cells. We have previously shown that the admin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cfb74ba2861866d7a7630a58040018
https://doi.org/10.4049/jimmunol.182.1.581
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6
Role of CD14 in Responses to Clinical Isolates ofEscherichia coli: Effects of K1 Capsule Expression
Autor: Sanna M. Goyert, Jack Silver, Erick Denamur, Alain Haziot, Shanjana Awasthi, Kwang Sik Kim, Sophie C. Gangloff, Shalaka Metkar, Saul Teichberg
Publikováno v: Infection and Immunity. 75:5415-5424
Severe bacterial infections leading to sepsis or septic shock can be induced by bacteria that utilize different factors to drive pathogenicity and/or virulence, leading to disease in the host. One major factor expressed by all clinical isolates of gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f5da17042246aff3e9da889bc05296
https://doi.org/10.1128/iai.00601-07
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7
Signaling through CD14 Attenuates the Inflammatory Response to Borrelia burgdorferi, the Agent of Lyme Disease
Autor: Melissa J. Caimano, Sanna M. Goyert, Raina A. Patel, Timothy J. Sellati, Wendy A. Lavezzi, Muhammad Naveed Akhtar, Danielle Wroblewski, Mohammed Rafii-El-Idrissi Benhnia, Sophie C. Gangloff, Justin D. Radolf
Publikováno v: The Journal of Immunology. 174:1539-1548
Lyme disease is a chronic inflammatory disorder caused by the spirochetal bacterium, Borrelia burgdorferi. In vitro evidence suggests that binding of spirochetal lipoproteins to CD14, a pattern recognition receptor expressed on monocytes/macrophages
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dec2fde06764d6e7612ce9f7cfa3e8
https://doi.org/10.4049/jimmunol.174.3.1539
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8
Persistence of apoptotic cells without autoimmune disease or inflammation in CD14−/− mice
Autor: Christopher D. Gregory, Adam Lacy-Hulbert, Andrew Devitt, Christopher Bellamy, Ceri E. Oldreive, Michael Clay, Kate G. Parker, Carol Anne Ogden, Sophie C. Gangloff, Sanna M. Goyert, Lynsey Melville
Publikováno v: The Journal of Cell Biology
Devitt, A, Parker, K G, Ogden, C A, Oldreive, C, Clay, M F, Melville, L A, Bellamy, C O, Lacy-Hulbert, A, Gangloff, S C, Goyert, S M & Gregory, C D 2004, ' Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/-mice ', Journal of Cell Biology, vol. 167, no. 6, pp. 1161-70 . https://doi.org/10.1083/jcb.200410057
Interaction of macrophages with apoptotic cells involves multiple steps including recognition, tethering, phagocytosis, and anti-inflammatory macrophage responses. Defective apoptotic cell clearance is associated with pathogenesis of autoimmune disea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8663e1a0817783e7d75e78ecc4ae4c6
https://doi.org/10.1083/jcb.200410057
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9
Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
Autor: Andrew E. Sama, Huan Yang, Seenu Susarla, Mahendar Ochani, Jianhua Li, Ping Wang, Haichao Wang, Luis Ulloa, Saijun Fan, Guoqian Chen, Xiaoling Qiang, Beatriz Rendon-Mitchell, Sanna M. Goyert, Kevin J. Tracey
Publikováno v: Journal of Leukocyte Biology. 76:994-1001
Bacterial endotoxin [lipopolysaccharide (LPS)] stimulates macrophages to sequentially release early [tumor necrosis factor (TNF)] and late [high mobility group box 1 (HMGB1)] proinflammatory cytokines. The requirement of CD14 and mitogen-activated pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5900c8ac00b73a6b50144705978eeff
https://doi.org/10.1189/jlb.0404242
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10
CD14-Deficient Mice Are Protected Against Lipopolysaccharide-Induced Cardiac Inflammation and Left Ventricular Dysfunction
Autor: Douglas L. Mann, Naoki Nozaki, Shintaro Nemoto, Jesus G. Vallejo, Sanna M. Goyert, Gilberto DeFreitas, Pascal Knuefermann, Blase A. Carabello, Arunima Misra
Publikováno v: Circulation. 106:2608-2615
Background—The molecular mechanisms responsible for sepsis-induced myocardial dysfunction remain undefined. CD14 mediates the inflammatory response to lipopolysaccharide (LPS) in various organs including the heart. In this study we investigated the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7b9802661c3bd592f404f1d075629c
https://doi.org/10.1161/01.cir.0000038110.69369.4c
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