Výsledky vyhledávání - "Sanna Mäkelä"

Akademický článek

S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.

Autor: Elina C V Brinck, Taru Virtanen, Sanna Mäkelä, Venla Soini, Ville-Veikko Hynninen, Jukka Mulo, Urmas Savolainen, Juho Rantakokko, Kreu Maisniemi, Antti Liukas, Klaus T Olkkola, Vesa Kontinen, Pekka Tarkkila, Marko Peltoniemi, Teijo I Saari

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0252626 (2021)

BackgroundSpinal fusion surgery causes severe pain. Strong opioids, commonly used as postoperative analgesics, may have unwanted side effects. S-ketamine may be an effective analgesic adjuvant in opioid patient-controlled analgesia (PCA). However, th

Externí odkaz: https://doaj.org/article/699d72d9c42a4f33971aa6c455afc4b9

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S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: a randomized, double-blind, placebo-controlled clinical trial

Autor: Vesa P. Kontinen, Kreu Maisniemi, Klaus T. Olkkola, Jukka Mulo, Taru Virtanen, Marko A. Peltoniemi, Teijo I. Saari, Venla Soini, Urmas Savolainen, Antti Liukas, Elina C. V. Brinck, P. Tarkkila, Sanna Mäkelä, Juho Rantakokko, Ville-Veikko Hynninen

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252626 (2021)

Background Spinal fusion surgery causes severe pain. Strong opioids, commonly used as postoperative analgesics, may have unwanted side effects. S-ketamine may be an effective analgesic adjuvant in opioid patient-controlled analgesia (PCA). However, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fab95267c6ced01e9fa32ab698f5a9
https://doi.org/10.1101/2021.01.22.21250352

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Characterization of metabolic interrelationships and in silico phenotyping of lipoprotein particles using self-organizing maps

Autor: Mika Ala-Korpela, Sanna Mäkelä, Minna L. Hannuksela, Kimmo Kaski, Markku J. Savolainen, Johanna Liinamaa, Linda S. Kumpula, Ville-Petteri Mäkinen, Anna Karjalainen

Publikováno v: Journal of Lipid Research, Vol 51, Iss 2, Pp 431-439 (2010)

Plasma lipid concentrations cannot properly account for the complex interactions prevailing in lipoprotein (patho)physiology. Sequential ultracentrifugation (UCF) is the gold standard for physical lipoprotein isolations allowing for subsequent analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cebd55595c02ad44d7b59dc4ddd65d7
https://doi.org/10.1194/jlr.d000760

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Ghrelin and obestatin modulate early atherogenic processes on cells: enhancement of monocyte adhesion and oxidized low-density lipoprotein binding

Autor: Maarit Jokela, Eija Kellokoski, Anne Kunnari, Y. Antero Kesäniemi, Sanna Mäkelä, Sohvi Hörkkö

Publikováno v: Metabolism. 58:1572-1580

Emerging evidence indicates the potential involvement of ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, in low-grade inflammatory diseases such as obesity and atherosclerosis. The goal of the present study was to use cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1759518c8ca1b7d7d7d7a52ba8a5ae86
https://doi.org/10.1016/j.metabol.2009.05.009

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HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid-rich HDL 2b particles

Autor: Markku J. Savolainen, Jari Metso, Minna L. Hannuksela, Sanna Mäkelä, Tiina M. Lehto, Mika Ala-Korpela, Matti Jauhiainen

Publikováno v: Alcoholism, clinical and experimental research. 32(6)

Background: Alcohol consumption is associated with increased serum high density lipoprotein (HDL) cholesterol levels and a decreased risk for the development of atherosclerosis. However, the effects of heavy alcohol intake on reverse cholesterol tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d237ee51f23b14f979b0d8eecae1f513
https://pubmed.ncbi.nlm.nih.gov/18498551

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Immunological detection of in vitro formed phosphatidylethanol--an alcohol biomarker--with monoclonal antibodies

Autor: Markku J. Savolainen, Marja K. Liisanantti, Antti E. Nissinen, Sohvi Hörkkö, Sanna Mäkelä, Minna L. Hannuksela, Jussi Vuoristo

Publikováno v: Alcoholism, clinical and experimental research. 32(6)

Background: Phosphatidylethanol (PEth) is a promising new marker for detecting long-term alcohol abuse with excellent sensitivity and specificity. Current methods are based on the high performance liquid chromatography–mass spectrometric method and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4560bd4499eb0bd7f0d732acc176aa
https://pubmed.ncbi.nlm.nih.gov/18445103

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1H NMR metabonomics of plasma lipoprotein subclasses: elucidation of metabolic clustering by self-organising maps

Autor: Markku J. Savolainen, Marja-Riitta Taskinen, Pasi Soininen, Kimmo Kaski, Minna L. Hannuksela, Aino Salminen, Sanna Mäkelä, Reino Laatikainen, Matti Jauhiainen, Mika Ala-Korpela, Petri Ingman, Teemu Suna

Publikováno v: NMR in biomedicine. 20(7)

1H NMR spectra of plasma are known to provide specific information on lipoprotein subclasses in the form of complex overlapping resonances. A combination of 1H NMR and self-organising map (SOM) analysis was applied to investigate if automated charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd791a6c759675f94b6fbdd82eff0f
https://pubmed.ncbi.nlm.nih.gov/17212341

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