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Akademický článek

Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.

Autor: Riccardo Provenzani, Ilari Tarvainen, Giulia Brandoli, Antti Lempinen, Sanna Artes, Ainoleena Turku, Maria Helena Jäntti, Virpi Talman, Jari Yli-Kauhaluoma, Raimo K Tuominen, Gustav Boije Af Gennäs

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0195668 (2018)

Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydro

Externí odkaz: https://doaj.org/article/011c3ac1fd414b3695e15b73be2e16e1

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Drug glucuronidation assays on human liver microsomes immobilized on microfluidic flow-through reactors

Autor: Tiina Sikanen, Iiro Kiiski, Sanna Artes, Ville Jokinen, Päivi Järvinen, Elisa Ollikainen

Publikováno v: European Journal of Pharmaceutical Sciences. 158:105677

UDP-glucuronosyltransferases (UGTs), located in the endoplasmic reticulum of liver cells, are an important family of enzymes, responsible for the biotransformation of several endogenous and exogenous chemicals, including therapeutic drugs. However, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f7f21c376bb7cc63cf1f6cc6b13c6a
https://doi.org/10.1016/j.ejps.2020.105677

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Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C

Autor: Virpi Talman, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Raimo K. Tuominen, Giulia Brandoli, Sanna Artes, Ilari Tarvainen, Ainoleena Turku, Riccardo Provenzani, Maria Jäntti, Antti Lempinen

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 4, p e0195668 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f33b09d254c462b05b286defef5f302
https://doi.org/10.1371/journal.pone.0195668

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Microfluidic Immobilized Enzyme Reactors for Prediction of Drug Clearance In Vivo

Autor: Iiro Matti Aleksi Kiiski, Sanna Artes, Ville Jokinen, Päivi Järvinen, Tiina Marjukka Sikanen

Publikováno v: University of Helsinki

We describe a microfluidic immobilized enzyme reactor that facilitates the screening of complex drug-drug interactions involving several different drug-metabolizing enzymes, and thus offers a comprehensive tool for in vitro prediction of a drug's met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4286180b4f28545ff229beeedeb745aa
https://researchportal.helsinki.fi/en/publications/cf37712b-c44a-4f32-b8a9-f98dde049d80

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