Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma: Results of the Proof-of-Concept iMYC Study

Autor: Fiona Turkes, Annette Bryant, Ruwaida Begum, Michael Davidson, Eleftheria Kalaitzaki, Maria Aresu, Retchel Lazaro-Alcausi, Jane Bryant, Isma Rana, Sue Chua, Lauren Aronson, Sanna Hulkki-Wilson, Charlotte Fribbens, David Watkins, Sheela Rao, Naureen Starling, David Cunningham, Irene Y. Chong, Ian Chau

Publikováno v: Current Oncology, Vol 29, Iss 4, Pp 2174-2184 (2022)

Oesophagogastric (OG) cancer is a highly lethal disease requiring novel treatment options. c-MYC and/or HER-2 amplified oesophageal cancer models have demonstrated sensitivity to BTK inhibition with ibrutinib. We evaluated the safety and efficacy of

Externí odkaz: https://doaj.org/article/5d5338a80b2f46c49f2a37fe4ad17d3e

Clonal diversity of MYC amplification evaluated by fluorescent in situ hybridisation and digital droplet polymerase chain reaction in oesophagogastric cancer: Results from a prospective clinical trial screening programme

Autor: Isma Rana, David Watkins, Lauren I. Aronson, Naureen Starling, Sheela Rao, Ian Chau, Retchel Lazaro-Alcausi, Irene Chong, Ruwaida Begum, Hanna Bryant, Marta Llorca Cardenosa, Michael Davidson, Monica Terlizzo, Sanna Hulkki-Wilson, John Swansbury, Julie Howard-Reeves, David Cunningham, Christopher J. Lord, Gina Brown, Eftheleria Kalaitzaki, Andrew Wotherspoon, Kyriakos Kouvelakis, Rosalind J. Cutts

Publikováno v: European Journal of Cancer. 122:12-21

The MYC proto-oncogene is among the most commonly dysregulated genes in human cancers. We report screening data from the iMYC trial, an ongoing phase II study assessing ibrutinib monotherapy in advanced pretreated MYC- and/or HER2-amplified oesophago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9da308b7dd2ddcf31637b76c1af82cc
https://doi.org/10.1016/j.ejca.2019.09.003

Intratumoral transcriptome heterogeneity is associated with patient prognosis and sidedness in patients with colorectal cancer treated with Anti-EGFR therapy from the CO.20 trial

Autor: Jonathan M. Loree, Dongsheng Tu, Christopher J. O'Callaghan, Elisa Fontana, Katherine Eason, C. Ragulan, Patrick Lawrence, Jeremy Shapiro, G. Nyamundanda, Chiara Cremolini, Lillian L. Siu, Ruwaida Begum, Sanna Hulkki-Wilson, Daniel Nava Rodrigues, Maggie C.U. Cheang, Anguraj Sadanandam, Maria Antonietta Bali, Naureen Starling, Livio Trusolino, Mirella Giordano, Timothy J. Price, Francesco Sclafani, Paul Waring, Derek J. Jonker, Filippo Pietrantonio, David Cunningham

PURPOSE Metastatic colorectal cancers (mCRCs) assigned to the transit-amplifying (TA) CRCAssigner subtype are more sensitive to anti–epidermal growth factor receptor (EGFR) therapy. We evaluated the association between the intratumoral presence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca61d46037665ee22b38521f175c292
http://hdl.handle.net/11568/1063518

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Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme

Autor: Colin R. Lindsay, Emily C. Shaw, Fiona Blackhall, Kevin G. Blyth, James D. Brenton, Anshuman Chaturvedi, Noel Clarke, Craig Dick, Thomas R.J. Evans, Geoff Hall, Andrew M. Hanby, David J. Harrison, Stephen R.D. Johnston, Malcolm D. Mason, Dion Morton, Julia Newton-Bishop, Andrew G. Nicholson, Karin A. Oien, Sanjay Popat, Doris Rassl, Rowena Sharpe, Phillipe Taniere, Ian Walker, William A. Wallace, Nicholas P. West, Rachel Butler, David Gonzalez de Castro, Mike Griffiths, Peter W.M. Johnson, Pauline Rehal, Samantha Butler, Matthew Smith, Rachel Doak, Anna Tanska, Graham Halford, Lisa James, Chris Kotara, Gareth Masson, Sam Clokie, Jennie Bell, Fiona Macdonald, David Gonzalez De Castro, Lisa Thompson, Debbie Mair, Suzanne Lillis, Dorte Wren, Robert Hollifield, Keeda Dover, Manisha Maurya, Damian Brooks, Belen Gomez, Lisa Grady, Thomas Jones, Chantal Hooper, Daphne Webster, Jolyon Travis, Stephanie Ogwuru, Jana Gazdova, Denise Collins, Elaine Chapman, Lisa Leavey, Paula Proszek, Sanna Hulkki, V.Peter Collins, Ash Ibrahim, Kat Brown, Jo Burge, Karen Burnett, Ginny Devonshire, Ellen Moseley, Bev Haynes, Charlotte Hodgkin, Merche Jimenez-linan, Linda Jones, Gilly Kenyon, Betania Mahler-araujo, Karen Payne, Jo Piper, Sue Richardson, Ed Rytina, Anne Warren, Liz Coker, Gemma Godsall, Mark Arends, Amanda O’Neill, Katy Rintoul, Donna Goymer, Julie Taylor, Claire Matthews, Harshil Bhayani, Tina Osalador, Zakiya Niwaz, Anna Higgins, Olivia Bamsey, Janine Salter, Louise Renouf, Glenn Noel-Storr, Helen Roberts, Kasia Gierejko, Paola Knapman, Andrew Wotherspoon, Gordon Stamp, Ayoma Attygailye, Steve Hazell, Peter Osin, Ash Nerurkar, Steven Francis, Marion Runde, Jo Arch, Xavier Chitnis, Bernard Siu, Debra Townsend, Laura Hennelly, Natalie Taylor, Bernadette Johnson, Susie Banerjee, Lynda Pyle, Monica Hamill, Jenny Gyertson, Angela George, Krishna Patel, Karla Pearce, Kim Edmonds, Sarah Sarker, Rosalind Eeles, Liz Bancroft, Sarah Thomas, Yukie Kano, Lisa Rowland, Karen Brooks, Mary O’brien, Jaishree Bhosle, Kathy Priest, Bee Ayite, Jo Severn, Helen Beedham, Nicky Lucas, Kim Tye, Alison Lorentzos, Janine Webb, Sarah Kerr, Lisa Corestav, Diego Bottero, Laura Jell, Janet Thomas, Cheryl Marriott, Neil Rajah, Andy Cole, Dieu Ly, Philippe Taniere, Brendan O’sullivan, Clare Swift, Frances Hughes, Desley Neil, Andrew Hanby, Roz Banks, Dolapo Ajayi, Alison Barclay, Julia Newton Bishop, Debbie Beirne, Andrew Bernard, Maxine Berry, Jo Bentley, Tim Bishop, Amy Chambers, Jude Clarke, Anne Crossley, Narinder Gahir, Debbie Gibson, Rona Good, Konstantina Grosios, Pat Harnden, Kate Hasler, Damien Hindmarch, Sharon Jackson, Colin Johnstone, Anne-marie Jones, Gil Lambert, Sally Lane, Nicola Mcnicholas, Rebecca Millican-Slater, Cath Moriaty, Alex Newsham, Kara O’connell, Lisa Ripley, David Sebag-Montefiore, Mary Simpson, Val Speirs, Joh Sugden, Lauren Tate, Emma Tidswell, Chris Twelves, Christy Walker, Barry Waterhouse, Martin Waugh, Louise White, Elizabeth Wright, Jane Rogan, Garry Ashton, Caron Abbey, Michelle Greenhalgh, Daisuke Nonaka, Elwyn Shing, Carmen Gibbard, Georgina Burton, Naomi Fawkes, Angela Marsden, Rachael Waddington, Phil Harrison, Shahrzad Moghadam, Kate Murray, Sarah Brown, Christy Mitchinson, Richard Booton, Rajesh Shah, David Harrison, Anca Oniscu, William Wallace, Frances Rae, Craig Marshall, Linda Mcleod, Morag Charles, Sarah Jane Sutherland, Carol Dawson, Paul Mitchell, Alex Maclellan, Sandra Muir, Lynne Johnstone, John O’connor, Shirley Johnstone, Jim Mcpherson, Jane Hair, Massimo Pignatelli, Roma Armstrong, Karin Oien, Jeff Evans, Margaret Burgoyne, Karen Blessing, Fraser Duthie, Colin Moyes, Elizabeth Mallon, David Millan, Fiona Roberts, Morag Seywright, Siobhan Fraser, Ian Ford, Sharon Kean, Marion Flood, David Grant, Claire Mcdonald, Tom Moffat, Hugh Mclelland, Alistair Kyle, Graham Cameron, Martin Wright, Stephen Kenny, Karen Mcauslan, Andrew Jones, Ted Fitzsimons, Fiona Graham, Alexandra Bell, Phil Duffy, Alec Fisher, Alexis Smith, Elaine Shannon, Bryan Woods, Colin Hutchison, Angela Booth, Lyndsay Duffy, Gillian Mcculloch, Hudda Sadiq, Susan Deakin, Steven Haywood, Malcolm Mason, John Chester, Alison Parry-jones, Abby Macarthur, Suzanne Williams, David Griffiths, Fiona Morgan, Hazel Bailey

Publikováno v: Lindsay, C, Shaw, E, Blackhall, F, Blyth, K, Brenton, J D, Chaturvedi, A, Clarke, N, Dick, C, Evans, T R J, Hall, G, Hanby, A M, Harrison, D J, Johnston, S, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D, Sharpe, R, Taniere, P, Walker, I, Wallace, W A, West, N P, Butler, R, Gonzales de Castro, D, Griffiths, M & Johnson, P W M 2018, ' Somatic cancer genetics in the UK : Real-world data from phase i of the Cancer Research UK Stratified Medicine Programme ', ESMO Open, vol. 3, no. 6, e000408 . https://doi.org/10.1136/esmoopen-2018-000408
Lindsay, C R, Shaw, E, Blackhall, F, Blyth, K G, Brenton, J D, Chaturvedi, A, Clarke, N W, Dick, C, Evans, T RJ, Hall, G, Hanby, A M, Harrison, D, Johnston, S, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D M, Sharpe, R, Taniere, P, Walker, I, Wallace, W, West, N P, Butler, R, Gonzales de Castro, D, Griffiths, M & Johnson, P WM 2018, ' Somatic Cancer Genetics in the UK: Real-World Data from Phase One of the Cancer Research UK Stratified Medicine Programme ', ESMO Open . https://doi.org/10.1136/esmoopen-2018-000408
Lindsay, C R, Shaw, E C, Blackhall, F, Blyth, K G, Brenton, J D, Chaturvedi, A, Clarke, N, Dick, C, Evans, T R J, Hall, G, Hanby, A M, Harrison, D J, Johnston, S R D, Mason, M D, Morton, D, Newton-Bishop, J, Nicholson, A G, Oien, K A, Popat, S, Rassl, D, Sharpe, R, Taniere, P, Walker, I, Wallace, W A, West, N P, Butler, R, Gonzalez de Castro, D, Griffiths, M & Johnson, P W M 2018, ' Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme ', ESMO Open, vol. 3, no. 6, e000408 . https://doi.org/10.1136/esmoopen-2018-000408

This study was supported by Cancer Research UK, AstraZeneca and Pfizer UK. Introduction: Phase I of the Cancer Research UK Stratified Medicine Programme (SMP1) was designed to roll out molecular pathology testing nationwide at the point of cancer dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8dd6fc53c00de7cc8875310844425e