Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sanket S, Acharya"'
Autor:
Xiao-Feng Zheng, Sanket S. Acharya, Katherine N. Choe, Kumar Nikhil, Guillaume Adelmant, Shakti Ranjan Satapathy, Samanta Sharma, Keith Viccaro, Sandeep Rana, Amarnath Natarajan, Peter Sicinski, Jarrod A. Marto, Kavita Shah, Dipanjan Chowdhury
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.
Externí odkaz:
https://doaj.org/article/2c564c99951247baadb473f227a8cb95
Autor:
David J. Logan, Sanket S. Acharya, David T. Scadden, Francois Mercier, Azeem Sharda, Cherrie Huang, Dongjun Lee, John G. Doench, John N. Hutchinson, Elizabeth W. Scadden, Michael Churchill, Ninib Baryawno, Sudeshna Das, Nick van Gastel, Vionnie W.C. Yu, Dana S'aulis, Stuart L. Schreiber, Shrikanta Chattophadhyay, Julien Cobert, Mark A. Keibler, Lars Bullinger, Vasanthi Viswanathan, David B. Sykes, Gregory Stephanopoulos, William B. Rizzo, Siddhartha Mukherjee, Borja Saez, Rushdia Z. Yusuf
Publikováno v:
Blood
Metabolic alterations in cancer represent convergent effects of oncogenic mutations. We hypothesized that a metabolism-restricted genetic screen, comparing normal primary mouse hematopoietic cells and their malignant counterparts in an ex vivo system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6308001e35725d9b153a7dd07ba9482
https://doi.org/10.1182/blood.2019001808
https://doi.org/10.1182/blood.2019001808
Autor:
Guillaume Adelmant, Kavita Shah, Peter Sicinski, Shakti Ranjan Satapathy, Sanket S. Acharya, Dipanjan Chowdhury, Keith Viccaro, Kumar Nikhil, Katherine N. Choe, Amarnath Natarajan, Sandeep Rana, Xiaofeng Zheng, Jarrod A. Marto, Samanta Sharma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a53d1c7a234c2702cc545903b8bcea
https://doi.org/10.1038/s41467-019-12084-x
https://doi.org/10.1038/s41467-019-12084-x
Autor:
Ana Pardo-Saganta, Francesca Ferraro, David T. Scadden, Radovan Vasic, Robyn Rouviere Day, Amir Schajnovitz, Rushdia Z. Yusuf, Colleen Cook, Vionnie W.C. Yu, Amy J. Wagers, Sanket S. Acharya, Stefania Lymperi, Stephen M. Sykes, Borja Saez, Charles P. Lin, Sutada Lotinun, Roland Baron, Simón Méndez-Ferrer, Rahul Palchaudhuri, Yu Yamaguchi, Raquel del Toro
Publikováno v:
Blood. 124:2937-2947
The glycosyltransferase gene, Ext1, is essential for heparan sulfate production. Induced deletion of Ext1 selectively in Mx1-expressing bone marrow (BM) stromal cells, a known population of skeletal stem/progenitor cells, in adult mice resulted in ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f761b7b97caa3009668c81c467e8084
https://doi.org/10.1182/blood-2014-08-593426
https://doi.org/10.1182/blood-2014-08-593426
Autor:
Justyna Chalubinska-Fendler, Peter Deraska, David Kozono, Dipanjan Chowdhury, Wojciech Fendler, Alan D. D'Andrea, Tru-Khang T. Dinh, Sanket S. Acharya, Colin O’Leary
Publikováno v:
Radiation Oncology (London, England)
Background Risk of normal tissue toxicity limits the amount of thoracic radiation therapy (RT) that can be routinely prescribed to treat non-small cell lung cancer (NSCLC). An early biomarker of response to thoracic RT may provide a way to predict ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cea239b3b1ff822863a0cca320f3b17
https://doi.org/10.1186/s13014-016-0636-4
https://doi.org/10.1186/s13014-016-0636-4
Autor:
Jacqueline Watson, Dipanjan Chowdhury, Sanket S. Acharya, Chandan Guha, Abigail Hamilton, Wojciech Fendler, Yunfeng Pan, Payel Bhanja, Emily F. Gaudiano, Patryk Moskwa, Kalindi Parmar, Subhrajit Saha
Publikováno v:
Science Translational Medicine. 7
Accidental radiation exposure is a threat to human health that necessitates effective clinical planning and diagnosis. Minimally invasive biomarkers that can predict long-term radiation injury are urgently needed for optimal management after a radiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58ed1af97156b6114763325cd3e646e
https://doi.org/10.1126/scitranslmed.aaa6593
https://doi.org/10.1126/scitranslmed.aaa6593
Autor:
Dipanjan Chowdhury, Guillaume Adelmant, Dong-Hyun Lee, Yinghua Guan, Jagesh V. Shah, David Pellman, Sanket S. Acharya, Peter Kalev, Jarrod A. Marto, Pascal Drané, Mijung Kwon
Excluding 53BP1 from chromatin is required to attenuate the DNA damage response during mitosis, yet the functional relevance and regulation of this exclusion is unclear. Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5261e76f5dbf50101822a82b5bb0e49e
https://europepmc.org/articles/PMC4030556/
https://europepmc.org/articles/PMC4030556/
Autor:
Stephen M, Sykes, Steven W, Lane, Lars, Bullinger, Demetrios, Kalaitzidis, Rushdia, Yusuf, Borja, Saez, Francesca, Ferraro, Francois, Mercier, Harshabad, Singh, Kristina M, Brumme, Sanket S, Acharya, Claudia, Scholl, Claudia, Schöll, Zuzana, Tothova, Eyal C, Attar, Stefan, Fröhling, Ronald A, DePinho, Scott A, Armstrong, D Gary, Gilliland, David T, Scadden
Summary AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tumor suppressors. We show a converse role for AKT/FOXOs in acute myeloid leukemia (AML). Rather than decreased FOXO activity, we observed that F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16588fb5847aad17b7e1d17edea2902b
https://europepmc.org/articles/PMC3826540/
https://europepmc.org/articles/PMC3826540/
Autor:
Tru-Khang T. Dinh, Justyna Chalubinska-Fendler, Colin O’Leary, Dipanjan Chowdhury, Wojciech Fendler, Alan D. D'Andrea, Peter Deraska, David Kozono, Sanket S. Acharya
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 93:E510
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ea2fe73c83681701075f4b1baf43bba
https://doi.org/10.1016/j.ijrobp.2015.07.1852
https://doi.org/10.1016/j.ijrobp.2015.07.1852
Autor:
Benjamin L. Ebert, Rushdia Z. Yusuf, Siddhartha Mukherjee, Hao Liu, Michael Churchill, Shrikanta Chattopadhyay, Lars Bullinger, Andrew L. Kung, David J. Logan, Matthew G. Vander Heiden, Colleen Cook, Borja Saez, Sanket S. Acharya, David T. Scadden, Anne E. Carpenter, Dongjun Lee, Sudeshna Das, Julien Cobert, Scott A. Armstrong, Francois Mercier, John G. Doench, Vionnie W.C. Yu, Adam Brown, Gohar Warraich, Dana S'aulis, Akachimere Cosmas Uzosike, Elizabeth W. Scadden, Stephen M. Sykes, Mildred Duvet, David B. Sykes, William B. Rizzo, Rahul Palchaudhuri
Publikováno v:
Blood. 120:208-208
Abstract 208 Altered metabolism has long been recognized as a signature finding of malignant cells with changes in glucose handling termed the ‘Warburg effect’. Now recognized as an adaptation of metabolic pathways to meet the distinctive demands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7abad18d2cf7e02720943ff2cc4c9b10
https://doi.org/10.1182/blood.v120.21.208.208
https://doi.org/10.1182/blood.v120.21.208.208