Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Sankar Jagadeeshan"'
Autor:
Ofra Novoplansky, Avital B. Shnerb, Divyasree Marripati, Sankar Jagadeeshan, Raghda Abu Shareb, Cristina Conde‐López, Jonathan Zorea, Manu Prasad, Talal Ben Lulu, Ksenia M. Yegodayev, Chen Benafsha, Yushi Li, Dexin Kong, Fengshen Kuo, Luc G. T. Morris, Ina Kurth, Jochen Hess, Moshe Elkabets
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2618-2636 (2023)
Blocking the mitogen‐activated protein kinase (MAPK) pathway with the MEK1/2 inhibitor trametinib has produced promising results in patients with head and neck squamous cell carcinoma (HNSCC). In the current study, we showed that trametinib treatme
Externí odkaz:
https://doaj.org/article/dfae4467864b4fe58887dab33f08a3c3
Autor:
Assaf Nahum, Yoni Koren, Bar Ergaz, Sari Natan, Gad Miller, Yuval Tamir, Shahar Goren, Avraham Kolel, Sankar Jagadeeshan, Moshe Elkabets, Ayelet Lesman, Assaf Zaritsky
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract Cells sense, manipulate and respond to their mechanical microenvironment in a plethora of physiological processes, yet the understanding of how cells transmit, receive and interpret environmental cues to communicate with distant cells is sev
Externí odkaz:
https://doaj.org/article/0fe11fe0ec0e4ef28f1c3f5ac55813f5
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In light of the development of RAS inhibitors, a reliable assessment of the prevalence of RAS mutations and their correlation with the clinical features of patients with HNC is crucially needed. This meta-analysis compiles the findings of 149 studies
Externí odkaz:
https://doaj.org/article/b79b6b8cf8e94de5a1b4f9721bf44f9d
Autor:
Barak Rotblat, Andreas Mock, Jerome Fayette, Limor Cohen, Idan Cohen, Elena Voronov, Jebrane Bouaoud, Lucas Michon, Pierre Saintigny, Luc G T Morris, Manu Prasad, Jonathan Zorea, Sankar Jagadeeshan, Avital B Shnerb, Sooraj Mathukkada, Ofra Novoplansky, Mai Badarni, Ksenia M Yegodayev, Sapir Tzadok, Libor Brezina, Andy Karabajakian, Tomer Cooks, Irit Allon, Orr Dimitstein, Benzion Joshua, Dexin Kong, Maurizio Scaltriti, Yaron Carmi, Cristina Conde-Lopez, Jochen Hess, Ina Kurth, Moshe Elkabets
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown clinically meaningful activity. Therefore, we aimed to characterize the effect o
Externí odkaz:
https://doaj.org/article/e52b0f83da384bc987314eeb1cc6f2e4
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-9 (2017)
Abstract Background Solanum nigrum, herbal plant that commonly grows in temperate climate zone, has been used as a traditional folk medicine whose ripen fruits were proven to exhibit anti-tumor properties. In traditional Chinese medicine, it has been
Externí odkaz:
https://doaj.org/article/2fa6dbeb0f4a4045a2c1e5cdee72ebe0
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70697 (2013)
The aim of this study is to test the hypothesis that the newly synthesized poly(δ-valerolactone)/poly(ethylene glycol)/poly(δ-valerolactone) (VEV) copolymer grafted with folic acid would impart targetability and further enhance the anti-tumor effic
Externí odkaz:
https://doaj.org/article/b09d2730d96146ac9ebdfc01fcf7832a
Autor:
Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben-Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire Saunders, Avital Beeri Shnerb, Jonathan Zorea, Ksenia M. Yegodayev, Monica Wainer, Liza Vtorov, Irit Allon, Ofir Cohen, Gro Gausdal, Dinorah Friedmann-Morvinski, Sok Ching Cheong, Alan L. Ho, Ari J. Rosenberg, Linda Kessler, Francis Burrows, Dexin Kong, Jennifer R. Grandis, J. Silvio Gutkind, Moshe Elkabets
Publikováno v:
Cancer Research. 83:1031-1047
The survival rate for patients with head and neck cancer (HNC) diagnosed with cervical lymph node (cLN) or distant metastasis is low. Genomic alterations in the HRAS oncogene are associated with advanced tumor stage and metastasis in HNC. Elucidation
Autor:
Moshe Elkabets, J. Silvio Gutkind, Jennifer R. Grandis, Dexin Kong, Francis Burrows, Linda Kessler, Ari J. Rosenberg, Alan L. Ho, Sok Ching Cheong, Dinorah Friedmann-Morvinski, Gro Gausdal, Ofir Cohen, Irit Allon, Liza Vtorov, Monica Wainer, Ksenia M. Yegodayev, Jonathan Zorea, Avital Beeri Shnerb, Claire Saunders, Sooraj Mathukkada, Vijayasteltar Belsamma Liju, Talal Ben-Lulu, Mai Badarni, Manu Prasad, Sankar Jagadeeshan
Supplementary Figures S1 to S6 with figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3a403322c503337cd547d6096d80d2
https://doi.org/10.1158/0008-5472.22549775.v1
https://doi.org/10.1158/0008-5472.22549775.v1
Autor:
Moshe Elkabets, J. Silvio Gutkind, Jennifer R. Grandis, Dexin Kong, Francis Burrows, Linda Kessler, Ari J. Rosenberg, Alan L. Ho, Sok Ching Cheong, Dinorah Friedmann-Morvinski, Gro Gausdal, Ofir Cohen, Irit Allon, Liza Vtorov, Monica Wainer, Ksenia M. Yegodayev, Jonathan Zorea, Avital Beeri Shnerb, Claire Saunders, Sooraj Mathukkada, Vijayasteltar Belsamma Liju, Talal Ben-Lulu, Mai Badarni, Manu Prasad, Sankar Jagadeeshan
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4703c78415f015112fa14bf1a713bfe5
https://doi.org/10.1158/0008-5472.22549778
https://doi.org/10.1158/0008-5472.22549778
Autor:
Moshe Elkabets, J. Silvio Gutkind, Jennifer R. Grandis, Dexin Kong, Francis Burrows, Linda Kessler, Ari J. Rosenberg, Alan L. Ho, Sok Ching Cheong, Dinorah Friedmann-Morvinski, Gro Gausdal, Ofir Cohen, Irit Allon, Liza Vtorov, Monica Wainer, Ksenia M. Yegodayev, Jonathan Zorea, Avital Beeri Shnerb, Claire Saunders, Sooraj Mathukkada, Vijayasteltar Belsamma Liju, Talal Ben-Lulu, Mai Badarni, Manu Prasad, Sankar Jagadeeshan
The survival rate for patients with head and neck cancer (HNC) diagnosed with cervical lymph node (cLN) or distant metastasis is low. Genomic alterations in the HRAS oncogene are associated with advanced tumor stage and metastasis in HNC. Elucidation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693c79924a84b91e65852c828b02d803
https://doi.org/10.1158/0008-5472.c.6560198
https://doi.org/10.1158/0008-5472.c.6560198