YAP mediates HIV-related liver fibrosis

Autor: Volney A. Spalding, Brian A. Fellenstein, James Ahodantin, Andre J. Jeyarajan, Yongtao Wang, Sanjoy K. Khan, Min Xu, Wenyu Lin, Nadia Alatrakchi, Lishan Su, Raymond T. Chung, Shadi Salloum

Publikováno v: JHEP Reports, Vol 6, Iss 11, Pp 101163- (2024)

Background & Aims: HIV accelerates liver fibrosis attributable to multiple etiologies, including HCV, HBV, and steatotic liver disease. Evidence also suggests that HIV infection itself is associated with liver fibrogenesis. Recent studies have implic

Externí odkaz: https://doaj.org/article/e74f747da88140ff9226da0f424d461b

Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase

Autor: Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e12cc853a36cd441fcfaf543a427312
http://www.sciencedirect.com/science/article/pii/S2352345X21001181

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

Autor: Sanjoy K. Khan, Young Eun Kim, Wantae Kim, Hanjun Kim, Eek-hoon Jho, Tohru Ishitani, Jason Dahlman, Ogyi Park, Yingzi Yang, Jelena Gvozdenovic-Jeremic, Bin Gao

Publikováno v: Journal of Clinical Investigation. 127:137-152

Malignant tumors develop through multiple steps of initiation and progression, and tumor initiation is of singular importance in tumor prevention, diagnosis, and treatment. However, the molecular mechanism whereby a signaling network of interacting p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fa608a4332c91ab959a74ed9fba49d
https://doi.org/10.1172/jci88486

Gαs signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling

Autor: Yingzi Yang, Ruoshi Xu, Sanjoy K. Khan, Xuedong Zhou, Bo Gao, Taifeng Zhou, Yaxing Zhou

Publikováno v: Bone Research, Vol 6, Iss 1, Pp 1-15 (2018)

How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec506de486cb01d0ceb5777b14a548e6
https://doi.org/10.1038/s41413-018-0034-7

Induced Gnas R201H expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling

Autor: Ruoshi Xu, Yingzi Yang, Dorothy Hu, Prem Swaroop Yadav, Sanjoy K. Khan, Gene Elliott

Publikováno v: Proceedings of the National Academy of Sciences. 115

Fibrous dysplasia (FD; Online Mendelian Inheritance in Man no. 174800) is a crippling skeletal disease caused by activating mutations of the GNAS gene, which encodes the stimulatory G protein Gαs. FD can lead to severe adverse conditions such as bon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1762355c78b936abf5cd3f35cb87e0cc
https://doi.org/10.1073/pnas.1714313114