Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sanjit Sanyal"'
Autor:
Chris H. Senanayake, Daniel R. Fandrick, Keith R. Fandrick, Christine A. Hart, James T. Masters, Max Sarvestani, Ifeanyi S. Okafor, Nelu Grinberg, Heewon Lee, Sanjit Sanyal, Jennifer L. Stockdill, Michael A. Mercadante, Nina C. Gonnella
Publikováno v:
Organic Letters. 18:6192-6195
The copper-catalyzed asymmetric propargylation of cyclic aldimines is reported. The influence of the imine trimer to inhibit the reaction was identified, and equilibrium constants between the monomer and trimer were determined for general classes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4947d55eca46b7429dc4f5403c15bb
https://doi.org/10.1021/acs.orglett.6b03253
https://doi.org/10.1021/acs.orglett.6b03253
Autor:
Nelu Grinberg, Jun Wang, Guisheng Li, Jon C. Lorenz, Joe Johnson, Xiufeng Sun, Heewon Lee, Yongda Zhang, Wenjie Li, Joe Gao, Sanjit Sanyal, Zhulin Tan, Nathan K. Yee, Bruce Z. Lu, Keith R. Fandrick, Jiang-Ping Wu, Chris H. Senanayake, Jonathan T. Reeves, Sonia Rodriguez
Publikováno v:
The Journal of Organic Chemistry. 81:2665-2669
An efficient asymmetric synthesis of 11-β-HSD inhibitor 1 has been accomplished in five linear steps and 53% overall yield, starting from the readily available 3-chloro-1-phenylpropan-1-one. The key feature of the synthesis includes an asymmetric me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05ceb16ed339e16e6c600f05b32d8f7
https://doi.org/10.1021/acs.joc.6b00189
https://doi.org/10.1021/acs.joc.6b00189
Autor:
Yuwen Wang, Frank Roschangar, Joseph Kaloko, Heewon Lee, Sanjit Sanyal, Jason A. Mulder, Ling Wu, Daniel R. Fandrick, Matthias Hoffmann, Chris H. Senanayake
Publikováno v:
Organic Letters. 17:2964-2967
A Michael equilibration model is presented to provide for site-selective pyrazole condensations between alkoxyacrylonitriles and hydrazines. Both pyrazole isomers were accessed with high selectivity by employment of kinetically or thermodynamically c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439cb514726be4f71d8020cc10f84189
https://doi.org/10.1021/acs.orglett.5b01248
https://doi.org/10.1021/acs.orglett.5b01248
Autor:
Nelu Grinberg, Marc-André Poupart, Jon C. Lorenz, Bo Qu, Nizar Haddad, Nina C. Gonnella, Shengli Ma, Nathan K. Yee, Wenjun Tang, Jiang-Ping Wu, Youla S. Tsantrizos, Wenjie Li, Joe Gao, Kanwar Sidhu, June Wang, Nitinchandra D. Patel, Sonia Rodriguez, Sanjit Sanyal, Heewon Lee, Yongda Zhang, Carl A. Busacca, Diana C. Reeves, Bruce Z. Lu, Keith R. Fandrick, Chris H. Senanayake
Publikováno v:
Angewandte Chemie. 127:7250-7254
A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the BI-DIME ligands for a ligand-controlled Suzuki c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d20ec4749c7a46e4ef82931f7fe303e
https://doi.org/10.1002/ange.201501575
https://doi.org/10.1002/ange.201501575
Autor:
Nina C. Gonnella, Nizar Haddad, Chris H. Senanayake, Zhibin Li, Markus Ostermeier, Jürgen Mack, Lukas Neumann, Nathan K. Yee, Zeno A. Leuter, Jürgen Schnaubelt, Gunter Koch, Emanuel Stehle, Sonja Steigmiller, Daniel R. Fandrick, Rainer Hamm, Sanjit Sanyal, Annette Buba, Yibo Xu, Waldemar Pfrengle, Patrick Tielmann, Dhileep Krishnamurthy, Shengli Ma, Rainer Soyka, Nelu Grinberg, Jürgen Däubler, Juan M. Rodriguez Dehli, Jinhua J. Song, Svenja Renner, Thomas Trieselmann, Jonathan T. Reeves, Christian Stange, Zhengxu S. Han, Sonia Rodriguez, Florian Schmelcher, Bo Qu
Publikováno v:
Organic Letters. 16:4142-4145
An efficient enantioselective synthesis of the chiral polycyclic cholesteryl ester transfer protein (CETP) inhibitor 1 has been developed. The synthesis was rendered practical for large scale via the development of a modified Hantzsch-type reaction t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13144222ec83698d34f684b6fab8b521
https://doi.org/10.1021/ol501833g
https://doi.org/10.1021/ol501833g
Autor:
Jean-Nicolas Desrosiers, Shengli Ma, Delia Reinhardt, Sanjit Sanyal, Heewon Lee, Nelu Grinberg, Keith R. Fandrick, Jinhua J. Song, Daniel R. Fandrick, Chris H. Senanayake
Publikováno v:
Organic Letters. 16:2834-2837
The rate limiting aromatization within the condensation approach toward pyrimidines utilizing amidines and activated olefins was addressed to provide for a general and rapid process. A strong solvent effect was elucidated to affect the rate for the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a69a3f41ef71781e9e1a2b398f9701e
https://doi.org/10.1021/ol500886a
https://doi.org/10.1021/ol500886a
Autor:
Frank Roschangar, Daniel R. Fandrick, Jinhua J. Song, Jaideep Saha, Chris H. Senanayake, Sanjit Sanyal, Junichi Ogikubo, Keith R. Fandrick, Heewon Lee
Publikováno v:
Organic Letters. 13:5616-5619
The general zinc-catalyzed allenylation of aldehydes and ketones with an allenyl boronate is presented. Preliminary mechanistic studies support a kinetically controlled process wherein, after a site-selective B/Zn exchange to generate a propargyl zin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa7eee03553c71c1bbde1ba1cfe751b
https://doi.org/10.1021/ol202343c
https://doi.org/10.1021/ol202343c
Autor:
Yuwen Wang, Joseph Kaloko, Matthias Hoffmann, Chris H. Senanayake, Ling Wu, Frank Roschangar, Daniel R. Fandrick, Jason A. Mulder, Heewon Lee, Sanjit Sanyal
Publikováno v:
ChemInform. 46
Conditions for the site-selective condensation between hydrazines and alkoxy 2-cyanoacrylates or their malononitrile counterparts are elaborated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31fbb1f8e7fb4b1170b805dea5389a24
https://doi.org/10.1002/chin.201544146
https://doi.org/10.1002/chin.201544146
Autor:
Nelu Grinberg, Shengli Ma, Keith R. Fandrick, Jean-Nicolas Desrosiers, Delia Reinhardt, Sanjit Sanyal, Jinhua J. Song, Heewon Lee, Chris H. Senanayake, Daniel R. Fandrick
Publikováno v:
ChemInform. 45
The rate limiting aromatization within the condensation approach toward pyrimidines utilizing amidines and activated olefins was addressed to provide for a general and rapid process. A strong solvent effect was elucidated to affect the rate for the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82ba72ff9b267cbf5548a05c22565c96
https://doi.org/10.1002/chin.201448167
https://doi.org/10.1002/chin.201448167
Autor:
Shengli Ma, Jean-Nicolas Desrosiers, Alexander Sienkiewicz, Larry Nummy, Daniel R. Fandrick, Jinhua J. Song, Xudong Wei, Sanjit Sanyal, Heewon Lee, Xingzhong Zeng, Christopher B. Kelly, Chris H. Senanayake, Max Sarvestani, Scot J. Campbell, Nelu Grinberg
Publikováno v:
Organic letters. 16(6)
A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698ed9f10ee1a00013c020512a482ce3
https://pubmed.ncbi.nlm.nih.gov/24601851
https://pubmed.ncbi.nlm.nih.gov/24601851