Výsledky vyhledávání - "Sanji Hagishita"

Absolute stereostructures of novel cytotoxic metabolites, penostatins A–E, from a Penicillium species separated from an Enteromorpha alga

Autor: Sanji Hagishita, Toshihide Oka, Atsushi Numata, Katsuhiko Minoura, Chika Iwamoto, T. Ohta

Publikováno v: Tetrahedron. 55:14353-14368

Penostatins A – E have been isolated from a strain of Penicillium sp. originally separated from the marine alga Enteromorpha intestinalis , and their absolute stereostructures and conformations have been established on the basis of spectral analyse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bb2d220b0f6a65be2601c13aafb0458
https://doi.org/10.1016/s0040-4020(99)00884-4

Zobrazit plný text záznamu

Penostatins F–I, novel cytotoxic metabolites from a Penicillium species separated from an Enteromorpha marine alga

Autor: Katsuhiko Minoura, Atsushi Numata, Kyosuke Nomoto, Sanji Hagishita, Chika Iwamoto

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :449-456

Penostatins F–I have been isolated from a strain of Penicillium sp. originally separated from the marine alga Enteromorpha intestinalis, and their stereostructures have been established on the basis of spectral analyses. All the compounds exhibit s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a432107d7b54d8d2f8cb060c3d8ba0e
https://doi.org/10.1039/a706853k

Zobrazit plný text záznamu

Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509

Autor: Ryuichi Kiyama, Yasuhiko Kanda, Susumu Kamata, Yasunobu Ishihara, Takeshi Shiota, Michio Ishikawa, Mayumi Shimamura, Toshiro Konoike, Koji Yoshimura, Nobuhiro Haga, Sanji Hagishita, Yasushi Murakami, Koji Abe, Kaoru Seno

Publikováno v: Bioorganic & Medicinal Chemistry. 5:1695-1714

A novel series of CCK-B/gastrin receptor antagonists—ureidomethylcarbamoylphenylketone derivatives—were designed, synthesized, and evaluated for activity. Structure-activity relationship studies revealed the importance of a carboxylic acid at sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a562eb2802c04ac1e31aeab3dcb98315
https://doi.org/10.1016/s0968-0896(97)00104-1

Zobrazit plný text záznamu

Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with noncyclic gastrin receptor antagonistic moieties

Autor: Tadahiko Tsushima, Shoichi Ishihara, Michio Ishikawa, Yasunobu Ishihara, Ryuichi Kiyama, Yasuyuki Kawanishi, Sanji Hagishita

Publikováno v: Bioorganic & Medicinal Chemistry. 5:1425-1431

In order to study structure-activity relationships of dual histamine H2 and gastrin receptor antagonists as well as to improve their low oral absorbability, their prototype benzodiazepine gastrin receptor antagonistic moieties were altered to a confo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3b8705cda3af838901d23de70250ec
https://doi.org/10.1016/s0968-0896(97)00076-x

Zobrazit plný text záznamu

Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with decreased hydrophobicity

Autor: Tadahiko Tsushima, Yasunobu Ishihara, Sanji Hagishita, Shoichi Ishihara, Yasuyuki Kawanishi, Michio Ishikawa

Publikováno v: Bioorganic & Medicinal Chemistry. 5:1401-1409

In order to study structure-activity relationships of the previously reported dual histamine H 2 and gastrin receptor antagonists and also to improve their low oral absorbability, we tried two chemical modifications. One tried to decrease the high hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3422620de55fe775b2c2e5732b1a3598
https://doi.org/10.1016/s0968-0896(97)00074-6

Zobrazit plný text záznamu

Synthesis and pharmacological evaluation of highly potent dual histamine H2 and gastrin receptor antagonists

Autor: Yasuyuki Kawanishi, Shoichi Ishihara, Tadahiko Tsushima, Mayumi Shimamura, Kaoru Seno, Noriko Shima, Masanori Miyagoshi, Yasunobu Ishihara, Sanji Hagishita, Michio Ishikawa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:1427-1430

The chemical modification of the dual histamine H2 and gastrin receptor antagonists described in our preceding paper, particularly the modification of spacers as well as the alteration of their connecting bonds at the gastrin receptor antagonist site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::136654fc15a9e67c9eff0e47b5294eeb
https://doi.org/10.1016/s0960-894x(96)00249-1

Zobrazit plný text záznamu

Design, synthesis, and pharmacological evaluation of dual histamine H2 and gastrin receptor antagonists

Autor: Yasuyuki Kawanishi, Sanji Hagishita, Masanori Miyagoshi, Mayumi Shimamura, Tadahiko Tsushima, Shoichi Ishihara, Michio Ishikawa, Noriko Shima, Yasunobu Ishihara, Kaoru Seno

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:1421-1426

The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c8f8d957f46cc67dba5c4a59798119b
https://doi.org/10.1016/s0960-894x(96)00248-x

Zobrazit plný text záznamu

Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives

Autor: Masahiko Ueno, Takashi Ono, Masaaki Yamada, Toshihiko Okada, Yasushi Murakami, Toshiyuki Kato, Yukiko Chikazawa, Yuji Ito, Mitsuaki Ohtani, Sanji Hagishita, Isao Teshirogi, Takaharu Matsuura, Katsutoshi Yamada, Masaaki Wada, Kazuhiro Shirahase

Publikováno v: Journal of Medicinal Chemistry. 39:3636-3658

Phospholipase A2 is an enzyme which hydrolyzes the sn-2 position of certain cellular phospholipids. The liberated lysophospholipid and arachidonic acid are precursors in the biosynthesis of various biologically active products. As human nonpancreatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914f7eb81c1a540a3c20589d0fccf93
https://doi.org/10.1021/jm960395q

Zobrazit plný text záznamu

Potent cytotoxic metabolites from a Leptosphaeria species. Structure determination and conformational analysis

Autor: Chika Takahashi, Tomohiro Sato, Takeshi Yamada, Tetsuro Shingu, Atsushi Numata, Hiroshi Nakai, Sanji Hagishita, Katsuhiko Kushida, Katsuhiko Minoura, Hiroshi Harada

Publikováno v: Tetrahedron. 51:3483-3498

New cytotoxic epipolysulfanyldioxopiperazine dimers, leptosins K (4), K1 (5) and K2 (6), have been isolated from a strain of Leptosphaeria sp. originally isolated from the marine alga Sargassum tortile. Their stereostructures, with a different config

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6174aad587ee2727ef3c3cb2acb0ef6a
https://doi.org/10.1016/0040-4020(95)00102-e

Zobrazit plný text záznamu

Synthesis of (2S,4S)- and (2S,4R)-[5,5,5-2H3] leucine from (R)-pulegone

Autor: Richard K. Hill, Claudio Abacherli, Sanji Hagishita

Publikováno v: Canadian Journal of Chemistry. 72:110-113

Beginning with (R)-pulegone, a CD3 group attached to the stereogenic center containing CH3 has been created by conversion to citronellal-1-d, exchange of the acidic hydrogens at C-2 by deuterium, and decarbonylation with Wilkinson's catalyst. Oxidati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cdb1b17b16496bc9e61034d87c9a39b
https://doi.org/10.1139/v94-017

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání