Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sanjeewa N. Senadheera"'
Autor:
Kristen H. Scherrer, Shainnel O. Eans, Jessica M. Medina, Sanjeewa N. Senadheera, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1218 (2023)
The macrocyclic tetrapeptide CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated
Externí odkaz:
https://doaj.org/article/e7827524f44543a88550968c9e396464
Autor:
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich
Publikováno v:
Molecules, Vol 25, Iss 17, p 3999 (2020)
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo. The present study evaluated the influence of the Phe residues’ stereochemistry on
Externí odkaz:
https://doaj.org/article/017a586349384007872af65cadb6d478
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 2038-2054 (2014)
We have developed a new photoremovable protecting group for caging phosphates in the near UV. Diethyl 2-(4-hydroxy-1-naphthyl)-2-oxoethyl phosphate (14a) quantitatively releases diethyl phosphate upon irradiation in aq MeOH or aq MeCN at 350 nm, with
Externí odkaz:
https://doaj.org/article/2be83a7ab9a6406e83e966849a8cf456
Autor:
Samaa Alrushaid, Casey L. Sayre, Jaime A. Yáñez, M. Laird Forrest, Sanjeewa N. Senadheera, Frank J. Burczynski, Raimar Löbenberg, Neal M. Davies
Publikováno v:
Pharmaceutics, Vol 9, Iss 3, p 35 (2017)
Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox’s bioavailability and tolerabi
Externí odkaz:
https://doaj.org/article/3090fddc4f504d7c9d83bde50c24e222
Autor:
Raghu S. Pandurangi, Orsolya Cseh, Hema Artee Luchman, Cynthia Xiuguang Ma, Sanjeewa N. Senadheera, Marcus Laird Forrest
Publikováno v:
ACS Pharmacology & Translational Science. 6:372-386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5883868afdb0f8addace6d3ec8f21d6
https://doi.org/10.1021/acsptsci.2c00091
https://doi.org/10.1021/acsptsci.2c00091
Autor:
Richard S. Givens, Sam V. Kaplan, Romana Jarosova, Sanjeewa N. Senadheera, Thomas M. Field, Michael A. Johnson
Publikováno v:
Anal Chem
Caged compounds are molecules that release a protective substrate to free a biologically active substrate upon treatment with light of sufficient energy and duration. A notable limitation of this approach is difficulty in determining the degree of ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8d8d26b69ba10c0b4e36658f02f829
https://doi.org/10.1021/acs.analchem.0c03452
https://doi.org/10.1021/acs.analchem.0c03452
Autor:
Thomas F. Murray, Jay P. McLaughlin, Sanjeewa N. Senadheera, Shainnel O. Eans, Ariana C. Brice-Tutt, Tanvir Khaliq, Jane V. Aldrich, Michelle L. Ganno
Publikováno v:
Molecules
Volume 25
Issue 17
Molecules, Vol 25, Iss 3999, p 3999 (2020)
Volume 25
Issue 17
Molecules, Vol 25, Iss 3999, p 3999 (2020)
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo. The present study evaluated the influence of the Phe residues&rsquo
stereochemi
stereochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dae573d777f9c215bb540af03a3919
Publikováno v:
European Journal of Medicinal Chemistry. 136:452-456
A new pH-activated polymer chelate of cisplatin was synthesized using a scalable and green aqueous technique. Synthesis of the chelate was based on formation of a 6-member ring of platinum(II) with acetyl-homo-Lysine (Ac-homo-Lys), which was accompli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4c8e76b1b72bb63762e941140bc463
https://doi.org/10.1016/j.ejmech.2017.05.020
https://doi.org/10.1016/j.ejmech.2017.05.020
Autor:
Zaid H. Maayah, Yunqi Zhao, Neal M. Davies, Samaa Alrushaid, Casey L. Sayre, Ayman O.S. El-Kadi, Hope D. Anderson, Kevin Chaboyer, M. Laird Forrest, Sanjeewa N. Senadheera
Doxorubicin is an effective anticancer drug; however, it is cardiotoxic and has poor oral bioavazilability. Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties. To mitigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd599551fbb2218691897335b694a81c
https://europepmc.org/articles/PMC5522622/
https://europepmc.org/articles/PMC5522622/
Autor:
Solomon A. Gisemba, Hamsa Thayele Purayil, Hanold Laura E, Jane V. Aldrich, Archana Mukhopadhyay, Sanjeewa N. Senadheera
Publikováno v:
Cancer biologytherapy. 18(8)
The oncoprotein c-Myc is often overexpressed in cancer cells, and the stability of this protein has major significance in deciding the fate of a cell. Thus, targeting c-Myc levels is an attractive approach for developing therapeutic agents for cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05894a99a16facfb2ae2dbde238f9832
https://pubmed.ncbi.nlm.nih.gov/28692379
https://pubmed.ncbi.nlm.nih.gov/28692379