Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sanjeeva J, Wijeyesakere"'
Publikováno v:
Toxicological Sciences. 193:18-30
We present a mechanistic machine-learning quantitative structure-activity relationship (QSAR) model to predict mammalian acute oral toxicity. We trained our model using a rat acute toxicity database compiled by the US National Toxicology Program. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed6392ed45046d048973e5f074a62ce
https://doi.org/10.1093/toxsci/kfad025
https://doi.org/10.1093/toxsci/kfad025
Publikováno v:
Applied In Vitro Toxicology. 8:129-138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472dd661ae81e45d4891218c67128857
https://doi.org/10.1089/aivt.2021.0028
https://doi.org/10.1089/aivt.2021.0028
Autor:
Mary Sue Marty, Sanjeeva J. Wijeyesakere, Daniel M. Wilson, Tyler R. Auernhammer, Amanda K. Parks, Dalila Kovacs
Publikováno v:
Applied In Vitro Toxicology. 5:196-204
Introduction: We are using big-data mining to develop computational models that predict whether previously uncharacterized compounds will or will not target important biological pathways. Mitochond...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2384f35c40d933f736d246d358ac083
https://doi.org/10.1089/aivt.2019.0010
https://doi.org/10.1089/aivt.2019.0010
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108245 (2014)
Patatin is a non-specific plant lipase and the eponymous member of a broad class of serine hydrolases termed the patatin-like phospholipase domain containing proteins (PNPLAs). Certain PNPLA family members can be inhibited by organophosphorus (OP) co
Externí odkaz:
https://doaj.org/article/d3f5cd2ac9d744c58af4f5bdba2ad267
Autor:
Tyler Peryea, Ahsan Habib Polash, Alessandra Roncaglioni, Daniel M. Wilson, Warren Casey, Patricia Ruiz, Nathalie Alépée, Sherif Farag, Giovanna J. Lavado, Kimberley M. Zorn, Alexey V. Zakharov, Davide Ballabio, Katrina M. Waters, Risa Sayre, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Nicole Kleinstreuer, Pankaj R. Daga, Sean Ekins, Kamel Mansouri, Liguo Wang, Judy Strickland, Matthew J. Hirn, Sudin Bhattacharya, Dac-Trung Nguyen, Emilio Benfenati, Ignacio J. Tripodi, Amanda K. Parks, Garett Goh, Dennis G. Thomas, Glenn J. Myatt, Prachi Pradeep, Gergely Zahoranszky-Kohalmi, Anton Simeonov, Arthur C. Silva, Grace Patlewicz, Timothy Sheils, Stephen Boyd, Agnes L. Karmaus, Ahmed Sayed, Alex M. Clark, Todd M. Martin, Pavel Karpov, Jeffery M. Gearhart, Robert Rallo, D Allen, Charles Siegel, Zhen Zhang, Zijun Xiao, Alexander Tropsha, Stephen J. Capuzzi, Alexandru Korotcov, Carolina Horta Andrade, Noel Southall, Viviana Consonni, Igor V. Tetko, Jeremy M. Fitzpatrick, Andrew J. Wedlake, Denis Fourches, Zhongyu Wang, Vinicius M. Alves, Eugene N. Muratov, Timothy E. H. Allen, Andrea Mauri, James B. Brown, Alexandre Varnek, Yun Tang, Sanjeeva J. Wijeyesakere, Daniel P. Russo, Cosimo Toma, Christopher M. Grulke, Michael S. Lawless, Domenico Gadaleta, Paritosh Pande, Thomas Hartung, Jonathan M. Goodman, Kristijan Vukovic, Joyce V. Bastos, Daniela Trisciuzzi, Fagen F. Zhang, Domenico Alberga, Thomas Luechtefeld, Dan Marsh, Tyler R. Auernhammer, Shannon M. Bell, Xinhao Li, Brian J. Teppen, F. Lunghini, Sergey Sosnin, Hao Zhu, Feng Gao, Craig Rowlands, Tongan Zhao, R Todeschini, Valery Tkachenko, Francesca Grisoni, Hongbin Yang, Yaroslav Chushak, Maxim V. Fedorov, Heather L. Ciallella, Gilles Marcou
Publikováno v:
Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10be9a3f401d14e1b5653e1242ab66
https://www.repository.cam.ac.uk/handle/1810/322114
https://www.repository.cam.ac.uk/handle/1810/322114
Autor:
Stephen W. Edwards, Kristie Sullivan, Sanjeeva J Wijeyesakere, Daniel M. Wilson, Amy J. Clippinger, Warren Casey, Kyle P. Glover, David G. Allen, Raja S. Settivari, Kamel Mansouri
Publikováno v:
ALTEX.
Efforts are underway to develop and implement nonanimal approaches which can characterize acute systemic lethality. A workshop was held in October 2019 to discuss developments in the prediction of acute oral lethality for chemicals and mixtures, as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27141082e18145dd2260ccbb2a73680
https://doi.org/10.14573/altex.2012121
https://doi.org/10.14573/altex.2012121
Autor:
Moshe Talpaz, Malini Raghavan, Jie Geng, Malathi Kandarpa, Sanjeeva J. Wijeyesakere, Ashwini Bhide, Irina D. Pogozheva, Arunkumar Venkatesan
Myeloproliferative neoplasms (MPNs) are frequently driven by insertions and deletions within the gene encoding calreticulin (CRT). CRTDel52 and CRTIns5 are recurrent mutations. Although oncogenic transformation requires both mutated CRT and the myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feb9be16817af65a79f321e7df7d57cd
https://doi.org/10.1101/2020.09.13.295485
https://doi.org/10.1101/2020.09.13.295485
Autor:
Arturo Anadón, Rudolf Andrys, Pavel Avdonin, Jiri Bajgar, Mahdi Balali-Mood, Frank Balszuweit, Atrayee Banerjee, Cheryl B. Bast, Daria Belinskaia, Vijay K. Bharti, Claire E. Bollinger, Robert P. Casillas, Ryan Clark, Edward D. Clarkson, Toby B. Cole, Rhian B. Cope, Robert W. Coppock, Lucio G. Costa, Wolf-D. Dettbarn, Alzbeta Dlabkova, Robin B. Doss, Margitta M. Dziwenka, Jorge Estevez, Tim J. Evans, John K. Fink, Swaran J.S. Flora, Clement E. Furlong, Josef Fusek, Jacqueline Garrick, Jeffery M. Gearhart, Donald R. Gerecke, Dana F. Glass-Mattie, Saryu Goel, Nikolay Goncharov, Richard K. Gordon, Joshua P. Gray, Zoran Grubic, Kavita Gulati, Ramesh C. Gupta, Sharon M. Gwaltney-Brant, Tracey A. Hamilton, Kenneth J. Harris, Darryl B. Hood, Edward M. Jakubowski, Richard Jenkins, David A. Jett, Yuqin Jiao, Harald John, Nathan H. Johnson, Milan Jokanović, Daniel Jun, Georgy Karakashev, Jiri Kassa, Maja Katalinic, Kai Kehe, Natalia Khlebnikova, Urmila P. Kodavanti, Ekaterina Korf, Nadezhda Koryagina, Bojan Kovač, Gopala Krishna, Mayur Krishna, Kamil Kuca, Dinesh Kumar, Yukio Kuroiwa, Sergey Kuznetsov, Kamil Kuča, Joseph C. Larsen, Mikhail Leninskiy, Jing Liu, Heather Lochotzki, Oksana Lockridge, Jordana Lockwich, Bommanna G. Loganathan, Dragana Lončar-Stojiljković, Sofya V. Lushchekina, Megan E. Lyman, Mark Maguire, Galina F. Makhaeva, Jitendra K. Malik, David Malinak, Tomaz Mars, Judit Marsillach, María-Rosa Martínez-Larrañaga, Patrick Masson, Shigeki Masunaga, Monique McCallister, Linda A. McCauley, Roger O. McClellan, Patrick M. McNutt, Edward C. Meek, Elaine Merrill, Sylvia Milanez, Igor Mindukshev, Katarina Mis, Jan Misik, Michael J. Murphy, Kamil Musilek, Tamie Nakajima, Marian R. Nelson, Eugenie Nepovimova, Tetsu Okumura, Jiri Patocka, Katarina Pegan, Jaroslav Pejchal, Sergej Pirkmajer, René Pita, Jason Pitt, Yiuka Pitt, Gennady E. Platoff, Carey N. Pope, Andrey Radilov, Anu Rahal, Aramandla Ramesh, Arunabha Ray, Vladimir Rembovskiy, Raina Rhoades, Rudy J. Richardson, Dragana Ristić, Peter J. Robinson, Alejandro Romero, Chris Ruark, Harry Salem, Natalia Samchenko, Tetsuo Satoh, Russell E. Savage, Elena Savelieva, Lawrence M. Schopfer, Alfred M. Sciuto, Yasuo Seto, Michael P. Shakarjian, Vladimir Shmurak, Adam Skarka, Ranko Škrbić, Miguel Sogorb, Shardell M. Spriggs, Sakshi Srivastava, Dirk Steinritz, Miloš P. Stojiljković, Neera Tewari-Singh, Horst Thiermann, Suresh Kumar Thokchom, Larry J. Thompson, Anton Ukolov, Luis G. Valerio, M.J. van der Schans, Daya R. Varma, Eugenio Vilanova, Annetta Watson, Sanjeeva J. Wijeyesakere, Tina Wismer, R. Mark Worden, Franz Worek, Linzzi K. Wright, Hidenori Yamasue, Takemi Yoshida, Toshiharu Yoshioka, Robert A. Young, Snjezana Zaja-Milatovic, Valeriy Zinchenko, Csaba K. Zoltani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85fe69eddc7f1d019dfca73327140c3
https://doi.org/10.1016/b978-0-12-819090-6.00078-7
https://doi.org/10.1016/b978-0-12-819090-6.00078-7
Autor:
John K. Fink, Paul Glynn, Sanjeeva J. Wijeyesakere, Rudy J. Richardson, Galina F. Makhaeva, Robert B. Hufnagel
Systemic inhibition of neuropathy target esterase (NTE) with certain organophosphorus (OP) compounds produces OP compound-induced delayed neurotoxicity (OPIDN), a distal degeneration of axons in the central nervous system (CNS) and peripheral nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f548928720485e3a606e29bf71fc61af
https://doi.org/10.1016/bs.ant.2020.01.001
https://doi.org/10.1016/bs.ant.2020.01.001