Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sanjeev Tohan"'
Autor:
Daniel C. Pevear, Guang Yang, Kem Waller, Erik Declercq, Robert O. Baker, Marc H. Davies, Barone Linda, Erin Touchette, Gerry Rhodes, R. L. Mark Buller, Sanjeev Tohan, John W. Huggins, Kevin F. Jones, Dennis E. Hruby, Thomas R. Bailey, Johan Neyts, Robert Jordan, Christopher J. Burns, Marc S. Collett, Jill Schriewer, Susan Rippen
Publikováno v:
Journal of Virology. 79:13139-13149
ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 μM), selective (concentration of compound that inhibited cell viability by 50% = >40 μM), and active a
Autor:
Thomas R. Bailey, Kathy A. Keith, Daniel C. Pevear, John W. Huggins, Robert O. Baker, Guang Yang, Christopher J. Burns, Marc S. Collett, Sanjeev Tohan, Gerry Rhodes, Dennis Hruby, Earl R. Kern, Elizabeth Opsitnick, Dongcheng Dai, Susan R. Rippin, Robert Jordan
Publikováno v:
Journal of medicinal chemistry. 50(7)
A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using structure--activity relationship information inferred from early hits, several compounds were