Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sanjeev Shangary"'
Autor:
Rongxiu Li, Amanda L. Boehm, Michelle B. Miranda, Sanjeev Shangary, Jennifer R. Grandis, Daniel E Johnson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 10, Pp 801-811 (2007)
Head, neck squamous cell carcinomas (HNSCCs) are frequently characterized by chemotherapy, radiation resistance, by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report, we examined whether cell-permeable pept
Externí odkaz:
https://doaj.org/article/6399e6065d584a95809896390bb0ce7b
Autor:
Shaomeng Wang, Thomas E. Carey, Carol R. Bradford, Denzil Bernard, Donna McEachern, Yipin Lu, Guoping Wang, Meilan Liu, Joshua A. Bauer, Zaneta Nikolovska-Coleska, Su Qiu, Ke Ding, Sanjeev Shangary
MDM2 oncoprotein binds directly to the p53 tumor suppressor and inhibits its function in cancers retaining wild-type p53. Blocking this interaction using small molecules is a promising approach to reactivate p53 function and is being pursued as a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433d3cfba377d44f73ac65c042036a03
https://doi.org/10.1158/1535-7163.c.6531546
https://doi.org/10.1158/1535-7163.c.6531546
Autor:
Shaomeng Wang, Thomas E. Carey, Carol R. Bradford, Denzil Bernard, Donna McEachern, Yipin Lu, Guoping Wang, Meilan Liu, Joshua A. Bauer, Zaneta Nikolovska-Coleska, Su Qiu, Ke Ding, Sanjeev Shangary
Supplementary Material from Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9407839d1a23c9940f1630ef3cd51f46
https://doi.org/10.1158/1535-7163.22484703
https://doi.org/10.1158/1535-7163.22484703
Autor:
Shaomeng Wang, Jeanne A. Stuckey, Jennifer L. Meagher, Yi Sun, Sanjeev Shangary, Han Yi, Rebecca S. Miller, Su Qiu, Donna McEachern, Zaneta Nikolovska-Coleska, Haiying Sun, Longchuan Bai, Jianfeng Lu
Supplementary Methods, Figures 1-15 from SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e7aac9f866c35ded4a9884154be2ec
https://doi.org/10.1158/0008-5472.22375851
https://doi.org/10.1158/0008-5472.22375851
Autor:
Laurent Debussche, Dimitri Gorge-Bernat, Pascal Pannier, Stéphane Guerif, Laurent Besret, Odette Dos-Santos, Angelo Aguilar, Denzil Bernard, Shanghai Yu, Sanjeev Shangary, Jianfeng Lu, Cassandra Gianna Hoffman-Luca, Liu Liu, Longchuan Bai, Jennifer L. Meagher, Jeanne A. Stuckey, Cédric Barrière, Isabelle Meaux, Donna McEachern, Yujun Zhao, Wei Sun, Shaomeng Wang
SI Table S1. Crystallography data collection and refinement statistics for the co-crystal structure of SAR405838 complexed with human MMD2 protein. SI Table S2. Binding affinities of SAR405838, as well as reference compounds to different MDM2 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10ee835201ab25b1bcd7983435e9cfe
https://doi.org/10.1158/0008-5472.22403966
https://doi.org/10.1158/0008-5472.22403966
Autor:
Shaomeng Wang, Laurent Besret, Shanghai Yu, Isabelle Meaux, Jennifer L. Meagher, Angelo Aguilar, Yujun Zhao, Donna McEachern, Cedric Barriere, Denzil Bernard, Jianfeng Lu, Laurent Debussche, Wei Sun, Cassandra Gianna Hoffman-Luca, Longchuan Bai, Jeanne A. Stuckey, Sanjeev Shangary, Stephane Guerif, Liu Liu, Dimitri Gorge-Bernat, Odette Dos-Santos, Pascal Pannier
Publikováno v:
Cancer Research. 74:5855-5865
Blocking the oncoprotein murine double minute 2 (MDM2)–p53 protein–protein interaction has long been considered to offer a broad cancer therapeutic strategy, despite the potential risks of selecting tumors harboring p53 mutations that escape MDM2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a3050e57a4675fc7db9fd95e4e4907
https://doi.org/10.1158/0008-5472.can-14-0799
https://doi.org/10.1158/0008-5472.can-14-0799
Publikováno v:
Protein Surface Recognition: Approaches for Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a11fe2133925da4862225eab95eecf
https://doi.org/10.1002/9780470972137.ch10
https://doi.org/10.1002/9780470972137.ch10
Autor:
Guoping Wang, Donna McEachern, Dongguang Qin, Shaomeng Wang, Sanjeev Shangary, Jianyong Chen, Sanmao Kang, Zaneta Nikolovska-Coleska, Ke Ding, Dajun Yang, Su Qiu, Rebecca Miller, Shanghai Yu
Publikováno v:
Journal of Medicinal Chemistry. 52:7970-7973
We report herein the design of potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. Compound 5 binds to MDM2 with a Ki value of 0.6 nM, activates p53 at concentrations as low as 40 nM, and potently and selectively inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e0aa71ecf9b301e0e9b364fe56ef09
https://doi.org/10.1021/jm901400z
https://doi.org/10.1021/jm901400z
Autor:
Shaomeng Wang, Sanjeev Shangary
Publikováno v:
Annual Review of Pharmacology and Toxicology. 49:223-241
Tumor suppressor p53 is an attractive cancer therapeutic target because it can be functionally activated to eradicate tumors. Direct gene alterations in p53 or interaction between p53 and MDM2 proteins are two alternative mechanisms for the inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059791bb9e42e9b05357805c1296b8ce
https://doi.org/10.1146/annurev.pharmtox.48.113006.094723
https://doi.org/10.1146/annurev.pharmtox.48.113006.094723
Autor:
Zaneta Nikolovska-Coleska, Haiying Sun, Su Qiu, Longchuan Bai, Han Yi, Donna McEachern, Jeanne A. Stuckey, Shaomeng Wang, Jennifer L. Meagher, Rebecca Miller, Yi Sun, Sanjeev Shangary, Jianfeng Lu
Publikováno v:
Cancer Research. 68:9384-9393
Small-molecule Smac mimetics are being developed as a novel class of anticancer drugs. Recent studies have shown that Smac mimetics target cellular inhibitor of apoptosis protein (cIAP)-1/2 for degradation and induce tumor necrosis factor-α (TNFα)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9205f87f76f067b45155324f1d42784b
https://doi.org/10.1158/0008-5472.can-08-2655
https://doi.org/10.1158/0008-5472.can-08-2655