Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Sanjeev A. Vasudevan"'
Autor:
Mercedes Barzi, Tong Chen, Trevor J. Gonzalez, Francis P. Pankowicz, Seh Hoon Oh, Helen L. Streff, Alan Rosales, Yunhan Ma, Sabrina Collias, Sarah E. Woodfield, Anna Mae Diehl, Sanjeev A. Vasudevan, Thao N. Galvan, John Goss, Charles A. Gersbach, Beatrice Bissig-Choisat, Aravind Asokan, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency. Here, we describe a human liver chimeric transgene-free Il2rg −/
Externí odkaz:
https://doaj.org/article/3464bdb424c442108002dbd891da2d8d
Autor:
Andres F. Espinoza, Kalyani R. Patel, Priya B. Shetty, Richard S. Whitlock, Pavel Sumazin, Xinjian Yu, Stephen F. Sarabia, Martin Urbicain, Andras Heczey, Prakash Masand, Sarah E. Woodfield, Dolores H. López‐Terrada, Sanjeev A. Vasudevan
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21270-21278 (2023)
Abstract Objective Hepatoblastoma (HB) is the most common primary hepatic malignancy in childhood. Relapse occurs in more than 50% of high‐risk patients with a high mortality due to ineffective salvage therapies. The purpose of this study is to ide
Externí odkaz:
https://doaj.org/article/0c97209ea30843db8d7cf1592b8908cd
Autor:
Smadar Kahana-Edwin, James Torpy, Lucy E. Cain, Anna Mullins, Geoffrey McCowage, Sarah E. Woodfield, Sanjeev A. Vasudevan, Dan P. T. Shea, Andre E. Minoche, Andres F. Espinoza, Sarah Kummerfeld, Leonard D. Goldstein, Jonathan Karpelowsky
Publikováno v:
Cancers, Vol 16, Iss 1, p 12 (2023)
Hepatoblastoma is characterized by driver mutations in CTNNB1, making it an attractive biomarker for a liquid biopsy approach utilizing circulating tumor DNA (ctDNA). This prospective observational study sought to ascertain the feasibility of ctDNA d
Externí odkaz:
https://doaj.org/article/480ac4a3d44c4ea48fb151f8fbf6958d
Autor:
Andres F. Espinoza, Ekene Onwuka, M John Hicks, Prakash Masand, Laura Monson, M. Fatih Okcu, Nina Pinglay, Allison Vidimos, Sanjeev A. Vasudevan
Publikováno v:
Journal of Pediatric Surgery Case Reports, Vol 92, Iss , Pp 102612- (2023)
Dermatofibrosarcoma Protuberans is an aggressive form of skin cancer in children. It has a slow growth rate and low chance of metastasizing but is notorious for its aggressive invasive and recurrent nature. In pediatric patients, the resections can b
Externí odkaz:
https://doaj.org/article/44c4ceaa6ca446328efb0aaaa70667d6
Autor:
Andres F. Espinoza, Michael E. Scheurer, Tiffany M. Chambers, Sanjeev A. Vasudevan, Philip J. Lupo
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
BackgroundHepatoblastoma (HB) is the most common primary liver cancer in children with emerging evidence that incidence is increasing globally. While overall survival for low risk hepatoblastoma is >90%, children with metastatic disease have worse su
Externí odkaz:
https://doaj.org/article/6f088e07236248a9a7f8ccfb7ed03799
Autor:
Andres F. Espinoza, Sanjeev A. Vasudevan, Prakash M. Masand, Dolores H. Lòpez-Terrada, Kalyani R. Patel
Publikováno v:
Cancers, Vol 15, Iss 19, p 4790 (2023)
Current understanding and classification of pediatric hepatocellular adenomas (HCA) are largely based on adult data. HCAs are rare in children and, unlike in adults, are often seen in the context of syndromes or abnormal background liver. Attempts to
Externí odkaz:
https://doaj.org/article/a874cee5b139455f8928e9e0b6586717
Autor:
Sarah E. Woodfield, Brandon J. Mistretta, Roma H. Patel, Aryana M. Ibarra, Kevin E. Fisher, Stephen F. Sarabia, Ilavarasi Gandhi, Jacquelyn Reuther, Zbigniew Starosolski, Andrew Badachhape, Jessica Epps, Barry Zorman, Aayushi P. Shah, Samuel R. Larson, Rohit K. Srivastava, Yan Shi, Andres F. Espinoza, Saiabhiroop R. Govindu, Richard S. Whitlock, Kimberly Holloway, Angshumoy Roy, Pavel Sumazin, Ketan B. Ghaghada, Dolores Lopez-Terrada, Preethi H. Gunaratne, Sanjeev A. Vasudevan
Publikováno v:
Biology Open, Vol 11, Iss 9 (2022)
Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models t
Externí odkaz:
https://doaj.org/article/19d25bfd932e459dbc19467d36d3ca80
Autor:
Myrthala Moreno-Smith, Giorgio Milazzo, Ling Tao, Baharan Fekry, Bokai Zhu, Mahmoud A. Mohammad, Simone Di Giacomo, Roshan Borkar, Karthik Reddy Kami Reddy, Mario Capasso, Sanjeev A. Vasudevan, Pavel Sumazin, John Hicks, Nagireddy Putluri, Giovanni Perini, Kristin Eckel-Mahan, Thomas P. Burris, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neurob
Externí odkaz:
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4
Autor:
Sarah E. Woodfield, Yan Shi, Roma H. Patel, Zhenghu Chen, Aayushi P. Shah, Richard S. Whitlock, Aryana M. Ibarra, Samuel R. Larson, Stephen F. Sarabia, Andrew Badachhape, Zbigniew Starosolski, Ketan B. Ghaghada, Pavel Sumazin, D. Allen Annis, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients have poor survival, and current chemotherapies are associated with significant toxicities. Targeted therapies are needed to improve outcomes and patient qu
Externí odkaz:
https://doaj.org/article/2c835b5e701047a99457ad48818f16a6
Autor:
Ling Tao, Myrthala Moreno‐Smith, Rodrigo Ibarra‐García‐Padilla, Giorgio Milazzo, Nathan A. Drolet, Blanca E. Hernandez, Young S. Oh, Ivanshi Patel, Jean J. Kim, Barry Zorman, Tajhal Patel, Abu Hena Mostafa Kamal, Yanling Zhao, John Hicks, Sanjeev A. Vasudevan, Nagireddy Putluri, Cristian Coarfa, Pavel Sumazin, Giovanni Perini, Ronald J. Parchem, Rosa A. Uribe, Eveline Barbieri
Publikováno v:
Advanced Science, Vol 8, Iss 19, Pp n/a-n/a (2021)
Abstract Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB patients, but not all patients respond, and most NBs event
Externí odkaz:
https://doaj.org/article/0d8406c5d32841488bb0468840a3531b