Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Sanjeev, Shukla"'
Autor:
Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant, Rushikesh Joshi, Jharna Mishra, Atul Samaiya, Sanjeev Shukla
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114367- (2024)
Summary: Cancer cells experiencing hypoxic stress employ epithelial-mesenchymal transition (EMT) to undergo metastasis through rewiring of the chromatin landscape, epigenetics, and importantly, gene expression. Here, we showed that hypoxia modulates
Externí odkaz:
https://doaj.org/article/e837af850e4345549f7f1208aee67737
Publikováno v:
Translational Oncology, Vol 37, Iss , Pp 101758- (2023)
Due to the enhanced glycolytic rate, cancer cells generate lactate copiously, subsequently promoting the lactylation of histones. While previous studies have explored the impact of histone lactylation in modulating gene expression, the precise role o
Externí odkaz:
https://doaj.org/article/2ef75d7f10754404bff7c79d4de70882
Autor:
Neelesh C. Reddy, Rajib Molla, Pralhad Namdev Joshi, Sajeev T. K., Ipsita Basu, Jyotsna Kawadkar, Neetu Kalra, Ram Kumar Mishra, Suman Chakrabarty, Sanjeev Shukla, Vishal Rai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Controlling the selectivity of the chemical modification of a genetic-manipulation-free protein is currently problematic. Here the authors report a method using cysteine-based chemoselective Linchpin Directed site-selective Modification of the lysine
Externí odkaz:
https://doaj.org/article/06df9bfd5b40499cacef9975977e5b0c
Autor:
Pooja Yadav, Anchala Pandey, Parik Kakani, Srinivas Abhishek Mutnuru, Atul Samaiya, Jharna Mishra, Sanjeev Shukla
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106804- (2023)
Summary: Alternative splicing of vascular endothelial growth factor A (VEGFA) generates numerous isoforms with unique roles in tumor angiogenesis, and investigating the underlying mechanism during hypoxia necessitates diligent pursuance. Our research
Externí odkaz:
https://doaj.org/article/78128716294d4f4cbb5312062688b8fa
Autor:
Tarun Mishra, Vipin Bhardwaj, Neha Ahuja, Pallavi Gadgil, Pavitra Ramdas, Sanjeev Shukla, Ajit Chande
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 202-218 (2022)
Strategies to modulate cellular DNA repair pathways hold immense potential to enhance the efficiency of CRISPR-Cas9 genome editing platform. In the absence of a repair template, CRISPR-Cas9-induced DNA double-strand breaks are repaired by the endogen
Externí odkaz:
https://doaj.org/article/aec1de2e40c24e4bb661baef453b20bf
Autor:
Jatinder Kumar, Muhammad Umar Alam, Seyed Behzad Jazayeri, Karthik Tanneru, Soroush Bazargani, Charu Shastri, Shiva Gautam, Shahriar Koochekpour, Sanjeev Shukla, Mark Bandyk, Joseph Costa, K C Balaji
Publikováno v:
Indian Journal of Urology, Vol 38, Iss 3, Pp 220-226 (2022)
Introduction: Studies directly comparing the different combination therapies offered to men with metastatic castration sensitive prostate cancer (mCSPC), are not available yet. This study was designed using the network meta-analysis (NMA) framework t
Externí odkaz:
https://doaj.org/article/59b248406d804304b894f4de9be34520
Publikováno v:
Oncogenesis, Vol 10, Iss 8, Pp 1-10 (2021)
Abstract Epithelial splicing regulatory protein 1 (ESRP1) is an RNA binding protein that governs the alternative splicing events related to epithelial phenotypes. ESRP1 contributes significantly at different stages of cancer progression. ESRP1 expres
Externí odkaz:
https://doaj.org/article/d1938a6672474734bcbe5fa95f566ca5
Autor:
Arpankumar Choksi, Apoorva Parulekar, Richa Pant, Vibhuti Kumar Shah, Ramakrishna Nimma, Priyanka Firmal, Smriti Singh, Gopal C. Kundu, Sanjeev Shukla, Samit Chattopadhyay
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the nuclear matrix wher
Externí odkaz:
https://doaj.org/article/3cbf96794131444bb48694d0054e2c0b
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101158- (2021)
Autophagy is considered an indispensable process that scavenges toxins, recycles complex macromolecules, and sustains the essential cellular functions. In addition to its housekeeping role, autophagy plays a substantial role in many pathophysiologica
Externí odkaz:
https://doaj.org/article/ee7fc403c6e2417cb5449f9b69758d75
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Aberrant alternative splicing is recognized to promote cancer pathogenesis, but the underlying mechanism is yet to be clear. Here, in this study, we report the frequent upregulation of SRSF10 (serine and arginine-rich splicing factor 10), a member of
Externí odkaz:
https://doaj.org/article/0f6aed64993444899bf8d9959584ab69