Zobrazeno 1 - 10 of 134 pro vyhledávání: '"Sanjeev, Mariathasan"'
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Akademický článek
Molecular residual disease detection in resected, muscle-invasive urothelial cancer with a tissue-based comprehensive genomic profiling–informed personalized monitoring assay
Autor: Thomas Powles, Amanda Young, Halla Nimeiri, Russell W. Madison, Alexander Fine, Daniel R. Zollinger, Yanmei Huang, Chang Xu, Ole V. Gjoerup, Vasily N. Aushev, Hsin-Ta Wu, Alexey Aleshin, Corey Carter, Nicole Davarpanah, Viraj Degaonkar, Pratyush Gupta, Sanjeev Mariathasan, Erica Schleifman, Zoe June Assaf, Geoffrey Oxnard, Priti S. Hegde
Publikováno v: Frontiers in Oncology, Vol 13 (2023)
IntroductionCirculating tumor DNA (ctDNA) detection postoperatively may identify patients with urothelial cancer at a high risk of relapse. Pragmatic tools building off clinical tumor next-generation sequencing (NGS) platforms could have the potentia
Externí odkaz: https://doaj.org/article/b572edde61804227913dfd5bf63af668
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4
Akademický článek
Molecular determinants of response to PD-L1 blockade across tumor types
Autor: Romain Banchereau, Ning Leng, Oliver Zill, Ethan Sokol, Gengbo Liu, Dean Pavlick, Sophia Maund, Li-Fen Liu, Edward Kadel, Nicole Baldwin, Suchit Jhunjhunwala, Dorothee Nickles, Zoe June Assaf, Daniel Bower, Namrata Patil, Mark McCleland, David Shames, Luciana Molinero, Mahrukh Huseni, Shomyseh Sanjabi, Craig Cummings, Ira Mellman, Sanjeev Mariathasan, Priti Hegde, Thomas Powles
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
PD-L1 immune checkpoint inhibition has been used for several tumour types. Here, the authors use immunohistochemistry, tumour mutation burden and RNA-seq data from 366 patients with different indications to identify molecular signatures of response t
Externí odkaz: https://doaj.org/article/ae29efdfced64f11b4172bdb2e1a8bde
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5
Akademický článek
Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
Autor: Andrew Wallace, Deepali Rishipathak, Mahesh Yadav, Sanjeev Mariathasan, Evan W Newell, Alessandra Nardin, Oliver A Zill, Michael Fehlings, Leesun Kim, Xiangnan Guan, Kobe Yuen, Alireza Tafazzol, Shomyseh Sanjabi, Siming Ma, Ana Milojkovic
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background A growing body of evidence suggests that T-cell responses against neoantigens are critical regulators of response to immune checkpoint blockade. We previously showed that circulating neoantigen-specific CD8 T cells in patients with lung ca
Externí odkaz: https://doaj.org/article/1b1d22e3dd284708b9bfcaa707c18a5e
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6
Akademický článek
Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
Autor: Marcin Kowanetz, Thomas Powles, Hartmut Koeppen, Jane Grogan, Patrick Caplazi, Ira Mellman, Wei Zou, Sanjeev Mariathasan, Priti S. Hegde, Mark McCleland, Jacqueline McBride, Zora Modrusan, Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, III, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Shadi Toghi Eshgi, W. Rodney Mathews, William E O'Gorman
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background CD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.Methods Here,
Externí odkaz: https://doaj.org/article/ccc1e210948b41af9f921790f0cfde0d
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