Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Sanjay de Mel"'
Autor:
Min Liu, Giorgio Bertolazzi, Shruti Sridhar, Rui Xue Lee, Patrick Jaynes, Kevin Mulder, Nicholas Syn, Michal Marek Hoppe, Shuangyi Fan, Yanfen Peng, Jocelyn Thng, Reiya Chua, Jayalakshmi, Yogeshini Batumalai, Sanjay De Mel, Limei Poon, Esther Hian Li Chan, Joanne Lee, Susan Swee-Shan Hue, Sheng-Tsung Chang, Shih-Sung Chuang, K. George Chandy, Xiaofei Ye, Qiang Pan-Hammarström, Florent Ginhoux, Yen Lin Chee, Siok-Bian Ng, Claudio Tripodo, Anand D. Jeyasekharan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows varying prognostic significance across studies in DLBCL, and does not provide a compr
Externí odkaz:
https://doaj.org/article/dcc5aed0ca7744c29e4e5d657125614a
Autor:
Wee-Lee Chan, Vanessa Cui Lian Chong, Ian Jun Yan Wee, Li Mei Poon, Esther Hian Lee Chan, Joanne Lee, Yen-Lin Chee, Anand D. Jeyasekharan, Wee-Joo Chng, Miny Samuel, Sanjay de Mel
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Rituximab-based chemo-immunotherapy is currently the standard first-line treatment for Waldenstrom macroglobulinaemia (WM), while ibrutinib has emerged as an alternative. In the absence of randomised trials (RCTs) comparing these regimens, t
Externí odkaz:
https://doaj.org/article/ff40f63f9b554a7eb8b5c591b218190b
Autor:
Tan Jiao Jie Cherie, Clarice Shi Hui Choong, Muhammad Bilal Abid, Matthew W. Weber, Eng Soo Yap, Suranjith L. Seneviratne, Visula Abeysuriya, Sanjay de Mel
Publikováno v:
Viruses, Vol 16, Iss 7, p 1090 (2024)
Dengue infection is caused by the dengue virus (DENV) and is transmitted to humans by infected female Aedes aegypti and Aedes albopictus mosquitoes. There are nearly 100 million new dengue cases yearly in more than 120 countries, with a five-fold inc
Externí odkaz:
https://doaj.org/article/21927340d7754099b05fa530d415b3ca
Autor:
Sanjay De Mel, Ainsley Ryan Lee, Joelle Hwee Inn Tan, Rachel Zi Yi Tan, Li Mei Poon, Esther Chan, Joanne Lee, Yen Lin Chee, Satish R. Lakshminarasappa, Patrick William Jaynes, Anand D. Jeyasekharan
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Deregulation of the DNA damage response (DDR) plays a critical role in the pathogenesis and progression of many cancers. The dependency of certain cancers on DDR pathways has enabled exploitation of such through synthetically lethal relationships e.g
Externí odkaz:
https://doaj.org/article/0056804496884dc7b3aedeaea78620e9
Autor:
Shin Yeu Ong, Sanjay de Mel, Nicholas Francis Grigoropoulos, Yunxin Chen, Yan Chin Tan, Melinda Si Yun Tan, Lawrence Cheng Kiat Ng, Yuh Shan Lee, Colin Phipps, Yeow Tee Goh, Kar Ying Yong, Xin Liu, Wee Joo Chng, Soon Thye Lim, Chandramouli Nagarajan
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 8, Pp 1-6 (2021)
Abstract The role of central nervous system (CNS) prophylaxis with high-dose methotrexate (HDMTX) in DLBCL is controversial. In this retrospective study, we evaluated the efficacy of prophylactic HDMTX on isolated CNS relapse, concomitant CNS and sys
Externí odkaz:
https://doaj.org/article/72111e925a8f4aaaac16a5c1f9fdd602
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Immunoglobulin M monoclonal gammopathy of undetermined significance (MGUS) comprises 15-20% of all cases of MGUS. IgM MGUS is distinct from other forms of MGUS in that the typical primary progression events include Waldenstrom macroglobulinaemia and
Externí odkaz:
https://doaj.org/article/c25acfa83ed442f38ed67acffa7050d9
Autor:
Yunlu Jia, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Regina Wan Ju Wong, Jing-Yuan Chooi, Julia Sze Lynn Lim, Takaomi Sanda, Melissa Ooi, Sanjay De Mel, Cinnie Soekojo, Yongxia Chen, Enfan Zhang, Zhen Cai, Peng Shen, Jian Ruan, Wee-Joo Chng
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 2, Pp 1-13 (2021)
Abstract Multiple myeloma (MM) is an aggressive plasma cell neoplasm characterized by genomic heterogeneity. Superenhancers (SEs) are defined as large clusters of enhancers in close genomic proximity, which regulate genes for maintaining cellular ide
Externí odkaz:
https://doaj.org/article/84a9518ee10c44cc91668e7428907d28
Autor:
Cho Mar Myint Wai, Shangying Chen, The Phyu, Shuangyi Fan, Sai Mun Leong, Wenning Zheng, Louis Ching Yi Low, Shoa-Nian Choo, Chi-Kuen Lee, Tae-Hoon Chung, Kenneth Hon Kim Ban, Soumita Ghosh, Stefanus Lie, Seiichi Kato, Shigeo Nakamura, Emiko Takahashi, Young-Hyeh Ko, Joseph D. Khoury, Shih-Sung Chuang, Rex K.H. Au-Yeung, Soo-Yong Tan, Soon-Thye Lim, Choon-Kiat Ong, Yong-Howe Ho, Li Mei Poon, Sanjay de Mel, Anand D. Jeyasekharan, Wee-Joo Chng, Franziska Otto, Leticia Quintanilla-Martinez, Federica Zanardi, Fabio Iannelli, Claudio Tripodo, Jason J. Pitt, Siok-Bian Ng
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Primary Epstein-Barr virus (EBV)-positive nodal T/NK-cell lymphoma (PTCL-EBV) is a poorly understood disease which shows features resembling extranodal NK/T-cell lymphoma (ENKTL) and is currently not recognized as a distinct entity but categorized as
Externí odkaz:
https://doaj.org/article/a40aa8b650d94f48ad7c2e61fdb54523
Autor:
Sanjay de Mel, Nurulhuda Mustafa, Viknesvaran Selvarajan, Muhammad Irfan Azaman, Patrick William Jaynes, Shruthi Venguidessane, Hoang Mai Phuong, Zubaida Talal Alnaseri, The Phyu, Louis-Pierre Girard, Wee Joo Chng, Joanna Wardyn, Ying Li, Omer An, Henry Yang, Siok Bian Ng, Anand D Jeyasekharan
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261469 (2022)
B-cell receptor (BCR) signalling is critical for the survival of B-cell lymphomas and is a therapeutic target of drugs such as Ibrutinib. However, the role of T-cell receptor (TCR) signalling in the survival of T/Natural Killer (NK) lymphomas is not
Externí odkaz:
https://doaj.org/article/3e882ec38a6740c399fb37fb203a9d49
Publikováno v:
Cancers, Vol 14, Iss 22, p 5654 (2022)
Multiple myeloma (MM) is the second-most common hematologic malignancy and remains incurable despite potent plasma cell directed therapeutics. The tumor microenvironment (TME) is a key player in the pathogenesis and progression of MM and is an active
Externí odkaz:
https://doaj.org/article/02659ac77d9e46f4ba40ae61fcbd6173