Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sanjay Thamake"'
Autor:
Othon Iliopoulos, Rodolfo F. Perini, Vivek Narayan, Jodi K. Maranchie, Sarah J. Welsh, Frede Donskov, Eric Jonasch, Stéphane Oudard, Sanjay Thamake, Benjamin L. Maughan, Mk Investigators, Eric Kristopher Park, Tobias Else, W. Kimryn Rathmell, Ramaprasad Srinivasan, W. Marston Linehan
Publikováno v:
Jonasch, E, Donskov, F, Iliopoulos, O, Rathmell, W K, Narayan, V K, Maughan, B L, Oudard, S, Else, T, Maranchie, J K, Welsh, S J, Thamake, S, Park, E K, Perini, R F, Linehan, W M, Srinivasan, R & the MK-6482-004 Investigators 2021, ' Belzutifan for renal cell carcinoma in von Hippel-Lindau disease ', New England Journal of Medicine, vol. 385, no. 22, pp. 2036-2046 . https://doi.org/10.1056/NEJMoa2103425
N Engl J Med
N Engl J Med
BACKGROUND: Patients with von Hippel–Lindau (VHL) disease have a high incidence of renal cell carcinoma owing to VHL gene inactivation and constitutive activation of the transcription factor hypoxia-inducible factor 2α (HIF-2α). METHODS: In this
Autor:
Rodolfo F. Perini, M. Dror Michaelson, David F. McDermott, Eric Jonasch, Todd M. Bauer, Jaime R. Merchan, Toni K. Choueiri, Leonard Joseph Appleman, Kyriakos P. Papadopoulos, Sanjay Thamake, Elizabeth R. Plimack, Naseem J. Zojwalla
Publikováno v:
Nature Medicine. 27:802-805
Hypoxia-inducible factor-2α (HIF-2α) is a transcription factor that frequently accumulates in clear cell renal cell carcinoma (ccRCC), resulting in constitutive activation of genes involved in carcinogenesis. Belzutifan (MK-6482, previously known a
Autor:
Leonard Joseph Appleman, Sanjay Thamake, Elizabeth R. Plimack, Naseem J. Zojwalla, Todd M. Bauer, Eric Jonasch, David F. McDermott, Jaime R. Merchan, M. Dror Michaelson, Rodolfo F. Perini, Toni K. Choueiri, Kyriakos P. Papadopoulos
Publikováno v:
Nature Medicine. 27:1849-1849
Autor:
M.D. Michaelson, Todd M. Bauer, Jaime R. Merchan, Leonard Joseph Appleman, Kyriakos P. Papadopoulos, Eric Jonasch, Toni K. Choueiri, Sanjay Thamake, Elizabeth R. Plimack, Naseem J. Zojwalla, David F. McDermott
Publikováno v:
Annals of Oncology. 30:v361-v362
Autor:
Kyriakos P. Papadopoulos, Leonard Joseph Appleman, Sanjay Thamake, David F. McDermott, M. Dror Michaelson, Todd M. Bauer, Rodolfo F. Perini, Elizabeth R. Plimack, Toni K. Choueiri, Jaime R. Merchan, Eric Kristopher Park, Eric Jonasch
Publikováno v:
Journal of Clinical Oncology. 39:273-273
273 Background: Clear cell RCC (ccRCC) accounts for ~70% of kidney cancer cases in the US. Several first-line therapies are approved for ccRCC, but few patients respond completely and most progress within 5-11 mo. A key oncogenic driver in RCC is the
Autor:
W. Kimryn Rathmell, Sarah J. Welsh, Vivek Narayan, Ramaprasad Srinivasan, Benjamin L. Maughan, Stéphane Oudard, W. Marston Linehan, Othon Iliopoulos, Tobias Else, Eric Kristopher Park, Jodi K. Maranchie, Eric Jonasch, Frede Donskov, Rodolfo F. Perini, Sanjay Thamake
Publikováno v:
Journal of Clinical Oncology. 39:333-333
333 Background: Patients (pts) with VHL disease are at risk of developing benign and malignant tumors, including ccRCC, pancreatic lesions tumors, CNS hemangioblastomas, and retinal lesions. Inactivation of VHL leads to stabilization of HIF-2α, whic
Autor:
Vivek Narayan, Eric Jonasch, W.K. Rathmell, Othon Iliopoulos, Rodolfo F. Perini, Eric Kristopher Park, Sanjay Thamake, Frede Donskov, Tobias Else, Benjamin L. Maughan, R. Srinivasan, Sarah J. Welsh, Stéphane Oudard, Jodi K. Maranchie, W.M. Linehan
Publikováno v:
Annals of Oncology. 31:S1158
Autor:
Izabela Tworowska, Ebrahim S. Delpassand, Sanjay Thamake, Konstantin Zhernosekov, Sebastian Marx, David Ranganathan, Alireza Mojtahedi, Michael K. Schultz
Publikováno v:
Nuclear Medicine and Biology. 43:19-26
Introduction 68Ga-DOTATATE is a radiolabeled peptide-based agonist that targets somatostatin receptors overexpressed in neuroendocrine tumors. Here, we present our results on validation of organic matrix 68Ge/68Ga generators (ITG GmbH) applied for ra
Autor:
Vivek Narayan, Sarah J. Welsh, Eric Kristopher Park, Benjamin L. Maughan, Eric Jonasch, Sanjay Thamake, Naseem J. Zojwalla, Othon Iliopoulos, Frede Donskov, Rodolfo F. Perini, Stéphane Oudard, Jodi K. Maranchie, Wendy Kimryn Rathmell, Tobias Else, Ramaprasad Srinivasan, W. Marston Linehan
Publikováno v:
Journal of Clinical Oncology. 38:5003-5003
5003 Background: Patients (pts) with Von Hippel-Lindau disease (VHL) are at risk for several cancers, including clear cell renal cell carcinoma (ccRCC). Inactivation of VHL results in constitutive activation of the HIF-2α transcription factor, which
Autor:
Toni K. Choueiri, Leonard Joseph Appleman, Elizabeth R. Plimack, Naseem J. Zojwalla, David F. McDermott, Jaime R. Merchan, Sanjay Thamake, Todd M. Bauer, M. Dror Michaelson, Eric Jonasch, Kyriakos P. Papadopoulos
Publikováno v:
Journal of Clinical Oncology. 38:611-611
611 Background: Hypoxia-inducible factor (HIF)-2α is a transcription factor that is a key oncogenic driver in RCC. MK-6482 is a first-in-class small molecule HIF-2α inhibitor that blocks the heterodimerization of HIF-2α with HIF-1β and induces re