Výsledky vyhledávání - "Sanjay Keswani"

Akademický článek

Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

Autor: Daniel Umbricht, Markus Abt, Paul Tamburri, Christopher Chatham, Štefan Holiga, Michael J. Frank, Anne G.E. Collins, David P. Walling, Rick Mofsen, Daniel Gruener, Lev Gertsik, Jeff Sevigny, Sanjay Keswani, Juergen Dukart

Publikováno v: Biological Psychiatry Global Open Science, Vol 1, Iss 1, Pp 70-77 (2021)

Background: Reduced activation of dopamine D1 receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highly expressed in the striatum,

Externí odkaz: https://doaj.org/article/4e96e9575d7248e086f19bdc0d374f88

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Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

Autor: Stefan Holiga, Daniel Umbricht, Rick Mofsen, Markus Abt, Michael J. Frank, Juergen Dukart, Sanjay Keswani, Lev Gertsik, Christopher H. Chatham, Daniel Gruener, Jeff Sevigny, Anne G.E. Collins, David P. Walling, Paul Tamburri

Publikováno v: Biological psychiatry 1(1), 70-77 (2021). doi:10.1016/j.bpsgos.2021.03.001
Biological Psychiatry Global Open Science, Vol 1, Iss 1, Pp 70-77 (2021)

Background Reduced activation of dopamine D1 receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highly expressed in the striatum, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055794a1effef60fcc6fd99358a3cd1d
https://hdl.handle.net/2128/28586

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Safety, Tolerability, and Clinical Pharmacology of ANX009, an Inhibitory Antibody Fab Fragment Against C1q, Administered Subcutaneously to Healthy Volunteers

Autor: Henk-André Kroon, Emily Radomile, Anita Grover, Jeffrey Teigler, Shawn Rose, Ted Yednock, Sanjay Keswani

Publikováno v: Blood. 138:3166-3166

Certain autoantibodies that bind to tissue antigens or that deposit in tissues as a component of immune complexes can activate the classical complement cascade, leading to inflammation and tissue damage. As the initiating molecule of the classical co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16cac47a1125ea2a02b91a59273b3f7b
https://doi.org/10.1182/blood-2021-153289

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Evidence of Classical Complement Pathway Involvement in a Subset of Patients with Warm Autoimmune Hemolytic Anemia

Autor: Wilma Barcellini, Ronald S. Go, Shawn Rose, Ted Yednock, Ellen Cahir-McFarland, Jeffrey Teigler, Julian Low, Hendrik Kroon, Sanjay Keswani

Publikováno v: Blood. 138:2001-2001

Introduction: Autoimmune Hemolytic Anemia (AIHA) is caused by autoantibodies that react with red blood cells (RBCs) resulting in predominantly extravascular hemolysis in an FcR and/or complement-dependent manner. In warm AIHA (wAIHA), autoantibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b75e72d90d7ff20b441f1964cd99cda6
https://doi.org/10.1182/blood-2021-153866

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Comparison of different QT interval correction methods for heart rate and QT beat-to-beat method in a thorough QT study of triple monoamine reuptake inhibitor BMS-820836

Autor: Maciej Gasior, David Burt, Malaz AbuTarif, Richard Bertz, Sanjay Keswani, Wai Chan, Ming Zheng, Dara Hawthorne, Zubin Bhagwagar

Publikováno v: The Journal of Clinical Pharmacology. 55:1137-1146

As BMS-820836 causes dose-dependent heart rate increases, QTcI, QTcF, QTcB, and QT beat-to-beat methods were compared in this thorough QT study in healthy subjects. Two parallel groups of subjects (n = 60 per group) received 2 mg (maximum therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc8fd84f235ac92ef13672986723189
https://doi.org/10.1002/jcph.528

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Safety, pharmacokinetic, and positron emission tomography evaluation of serotonin and dopamine transporter occupancy following multiple-dose administration of the triple monoamine reuptake inhibitor BMS-820836

Autor: Roger M. Lane, Matthew Cahir, David Burt, Zubin Bhagwagar, Robert Risinger, Sanjay Keswani, Gunnar Antoni, Feng Luo, Lieuwe Appel, Ming Zheng, Wendy Hayes

Publikováno v: Psychopharmacology. 232(3)

BMS-820836 is a novel antidepressant that selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine.This Phase I study assessed safety, tolerability, and pharmacokinetics of multiple daily doses of BMS-820836 in healthy subjects. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a84fdea99e46d0a62e342b8d6c8aed
https://pubmed.ncbi.nlm.nih.gov/25116481

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Granzyme B mediates neurotoxicity through a G‐protein‐coupled receptor

Autor: Tongguang Wang, Rameeza Allie, Katherine Conant, Norman Haughey, Jadwiga Turchan-Cholewo, Katrin Hahn, Antony Rosen, Joseph Steiner, Sanjay Keswani, Melina Jones, Peter A. Calabresi, Avindra Nath

Publikováno v: The FASEB Journal. 20:1209-1211

Neuroinflammatory diseases such as multiple sclerosis (MS) are characterized by focal regions of demyelination and axonal loss associated with infiltrating T cells. However, the role of activated T cells in causing neuronal injury remains unclear. CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0c3e0cf298ce748d02c235d6207cd0
https://doi.org/10.1096/fj.05-5022fje

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Phase I single and multiple dose study to evaluate the safety, tolerability, and pharmacokinetics of BMS-927711 in healthy subjects

Autor: Naiyu Zheng, David Burt, Adela Buzescu, Richard Bertz, G Tong, Ishani Savant, Sanjay Keswani, N Jariwala, R Marcus

Publikováno v: The Journal of Headache and Pain

Calcitonin gene-related peptide (CGRP) may play a causal role in migraine. Blocking the CGRP receptor may be an effective approach to migraine relief while avoiding the vasoconstrictive effects associated with triptans. BMS-927711 is a potent, select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c117d700ec928cb9aa0bcedfb80ed6
http://europepmc.org/articles/PMC3619991

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