Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sanjay K Srikakulam"'
Publikováno v:
Bioinformatics. 39
MotivationBloom filters are a popular data structure that allows rapid searches in large sequence datasets. So far, all tools work with nucleotide sequences; however, protein sequences are conserved over longer evolutionary distances, and only mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63072b67275d81745bdf8e8737ed8a33
https://doi.org/10.1093/bioinformatics/btad101
https://doi.org/10.1093/bioinformatics/btad101
MotivationCompared to eukaryotes, prokaryote genomes are more diverse through different mechanisms, including a higher mutation rate and horizontal gene transfer. Therefore, using a linear representative reference can cause a reference bias. Graph-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3f3a4457d0075ae4e912ae09514caab
https://doi.org/10.1101/2023.01.19.524778
https://doi.org/10.1101/2023.01.19.524778
Publikováno v:
GigaScience
Background Structural annotation of genetic variants in the context of intermolecular interactions and protein stability can shed light onto mechanisms of disease-related phenotypes. Three-dimensional structures of related proteins in complexes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d676bff9b73510f6aa004f7d33c3b5db
https://hdl.handle.net/21.11116/0000-000B-4789-B21.11116/0000-000B-478B-9
https://hdl.handle.net/21.11116/0000-000B-4789-B21.11116/0000-000B-478B-9
Autor:
Georg, Dultz, Sanjay K, Srikakulam, Michael, Konetschnik, Tetsuro, Shimakami, Nadezhda T, Doncheva, Julia, Dietz, Christoph, Sarrazin, Ricardo M, Biondi, Stefan, Zeuzem, Robert, Tampé, Olga V, Kalinina, Christoph, Welsch
Publikováno v:
The Journal of Biological Chemistry
The Q80K polymorphism in the NS3-4A protease of the hepatitis C virus is associated with treatment failure of direct-acting antiviral agents. This polymorphism is highly prevalent in genotype 1a infections and stably transmitted between hosts. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5db89266d2b7780ba06d00ba4166082f
https://pubmed.ncbi.nlm.nih.gov/34339738
https://pubmed.ncbi.nlm.nih.gov/34339738