Zobrazeno 1 - 10
of 377
pro vyhledávání: '"Sanjay K Jain"'
Autor:
Sivaranjani Namasivayam, Curtis Tilves, Hua Ding, Shaoguang Wu, Jada C Domingue, Camilo Ruiz-Bedoya, Ankit Shah, Eric Bohrnsen, Benjamin Schwarz, Mickayla Bacorn, Qing Chen, Shira Levy, Maria Gloria Dominguez Bello, Sanjay K Jain, Cynthia L Sears, Noel T Mueller, Suchitra K Hourigan
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Exposing C-section infants to the maternal vaginal microbiome, coined “vaginal seeding”, partially restores microbial colonization. However, whether vaginal seeding decreases metabolic disease risk is unknown. Therefore, we assessed the effect of
Externí odkaz:
https://doaj.org/article/ed1023d96e4e4dfa90f0fb2d54bb814f
Autor:
Alvaro A Ordonez, Supriya Pokkali, Sunhwa Kim, Brian Carr, Mariah H Klunk, Leah Tong, Vikram Saini, Yong S Chang, Matthew McKevitt, Victoria Smith, David L Gossage, Sanjay K Jain
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197474 (2018)
Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune responses to Mycobacterium tuberculosis infection, macrophage recruitment and granuloma formation. We evaluated whether adjunctive inhibition of MMP-9 could im
Externí odkaz:
https://doaj.org/article/54b3f2022fb249b6970c61b92e430123
Autor:
Zhuo Zhang, Alvaro A Ordonez, Peter Smith-Jones, Hui Wang, Kayla R Gogarty, Fereidoon Daryaee, Lauren E Bambarger, Yong S Chang, Sanjay K Jain, Peter J Tonge
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170871 (2017)
5-[18F]F-pyrazinamide (5-[18F]F-PZA), a radiotracer analog of the first-line tuberculosis drug pyrazinamide (PZA), was employed to determine the biodistribution of PZA using PET imaging and ex vivo analysis. 5-[18F]F-PZA was synthesized in 60 min usi
Externí odkaz:
https://doaj.org/article/b645b581b9464ab5b1df345ed1325e5c
Autor:
Ciaran Skerry, Supriya Pokkali, Michael Pinn, Nicholas A Be, Jamie Harper, Petros C Karakousis, Sanjay K Jain
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66310 (2013)
We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB). Specifically, PknD mediates bacillary invasion of the blood-brain barri
Externí odkaz:
https://doaj.org/article/de2334973bd64c369211bcd0f0f19958
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39680 (2012)
It has been hypothesized that early host-responses during TB treatment may paradoxically promote survival of persistent bacteria. We therefore evaluated whether adjunctive inhibition of tumor necrosis factor alpha (TNF-α)-a key cytokine in host resp
Externí odkaz:
https://doaj.org/article/ae9743ee317a4ff89b014c5eba6fe470
Autor:
Stephanie L Davis, Nicholas A Be, Gyanu Lamichhane, Sridhar Nimmagadda, Martin G Pomper, William R Bishai, Sanjay K Jain
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6297 (2009)
Bacteria can be selectively imaged in experimentally-infected animals using exogenously administered 1-(2'deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-[(125)I]-iodouracil ([(125)I]-FIAU), a nucleoside analog substrate for bacterial thymidine kinase (TK
Externí odkaz:
https://doaj.org/article/dc59655975eb44429f5e5deb0c9f038b
Autor:
Filipa Mota, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Daniel P. Holt, Patricia De Jesus, Martin A. Lodge, Clara Erice, Xueyi Chen, Melissa Bahr, Kelly Flavahan, John Kim, Mary Katherine Brosnan, Alvaro A. Ordonez, Charles A. Peloquin, Robert F. Dannals, Sanjay K. Jain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the cent
Externí odkaz:
https://doaj.org/article/f0a782321c4e4e36aa37ab969660b2e2
Autor:
Brett M. Babin, Gabriela Fernandez-Cuervo, Jessica Sheng, Ori Green, Alvaro A. Ordonez, Mitchell L. Turner, Laura J. Keller, Sanjay K. Jain, Doron Shabat, Matthew Bogyo
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 803-814 (2021)
Externí odkaz:
https://doaj.org/article/a4f9610f36c44840bfaaf3df10a22e57
Autor:
Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Maria I. Reyes-Mantilla, Clara Erice, Melissa Bahr, Kelly Flavahan, Patricia de Jesus, John Kim, Catherine A. Foss, Charles A. Peloquin, Dima A. Hammoud, Alvaro A. Ordonez, Carlos A. Pardo, Sanjay K. Jain
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality. High-dose rifampin (35 mg/kg/d) is safe and improves the ba
Externí odkaz:
https://doaj.org/article/60a8e9fb510a41cda1c8b3797413d48b
Autor:
Alvaro A. Ordonez, Matthew F.L. Parker, Robert J. Miller, Donika Plyku, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Justin M. Luu, Dustin A. Dikeman, Wojciech G. Lesniak, Daniel P. Holt, Robert F. Dannals, Lloyd S. Miller, Steven P. Rowe, David M. Wilson, Sanjay K. Jain
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the
Externí odkaz:
https://doaj.org/article/5177739448e9442882f49a5d260f8ffe