Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sanjay Bhattarai"'
Autor:
Sujan Devkota, Rui Zhou, Vaishnavi Nagarajan, Masato Maesako, Hung Do, Arshad Noorani, Caitlin Overmeyer, Sanjay Bhattarai, Justin T. Douglas, Anita Saraf, Yinglong Miao, Brian D. Ackley, Yigong Shi, Michael S. Wolfe
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113761- (2024)
Summary: Mutations that cause familial Alzheimer’s disease (FAD) are found in amyloid precursor protein (APP) and presenilin, the catalytic component of γ-secretase, that together produce amyloid β-peptide (Aβ). Nevertheless, whether Aβ is the
Externí odkaz:
https://doaj.org/article/946405b54cfb4ca6ae682b16e8ead2ff
Publikováno v:
Crystals, Vol 14, Iss 2, p 177 (2024)
This paper focuses on the research and development of high-purity germanium (HPGe) crystals for detector fabrication, specifically targeting applications in rare-event physics searches. The primary objective was to produce large-scale germanium cryst
Externí odkaz:
https://doaj.org/article/69a68f27be9544798b1ead4d22988978
Publikováno v:
ACS Central Science, Vol 6, Iss 6, Pp 969-983 (2020)
Externí odkaz:
https://doaj.org/article/bbbf83652e3240fc89040e3623db3a1f
Autor:
Apurba Bhattarai, Sujan Devkota, Hung Nguyen Do, Jinan Wang, Sanjay Bhattarai, Michael S. Wolfe, Yinglong Miao
Publikováno v:
J Am Chem Soc
The membrane-embedded γ-secretase complex processively cleaves within the transmembrane domain of amyloid precursor protein (APP) to produce 37-to-43-residue amyloid β-peptides (Aβ) of Alzheimer’s disease (AD). Despite its importance in pathogen
Autor:
Mathbar Raut, Dongming Mei, Sanjay Bhattarai, Rajendra Panth, Kyler Kooi, Hao Mei, Guojian Wang
This study investigates new technology for enhancing the sensitivity of low-mass dark matter detection by analyzing charge transport in a p-type germanium detector at 5.2 K. To achieve low-threshold detectors, precise calculations of the binding ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34a03b9bab7f3f09a77b24a7a9618b19
https://doi.org/10.21203/rs.3.rs-2752594/v1
https://doi.org/10.21203/rs.3.rs-2752594/v1
Autor:
Lei, Liu, Bianca M, Lauro, Amy, He, Hyo, Lee, Sanjay, Bhattarai, Michael S, Wolfe, David A, Bennett, Celeste M, Karch, Tracy, Young-Pearse, Dennis J, Selkoe
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's Association.
Identifying CSF-based biomarkers for the β-amyloidosis that initiates Alzheimer's disease (AD) could provide inexpensive and dynamic tests to distinguish AD from normal aging and predict future cognitive decline.We developed immunoassays specificall
Publikováno v:
Machine Learning and Systems Biology in Genomics and Health ISBN: 9789811659928
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::823b5e26de22752f004be91b2f7bc99f
https://doi.org/10.1007/978-981-16-5993-5_2
https://doi.org/10.1007/978-981-16-5993-5_2
Autor:
Sanjay Bhattarai, Norbert Sträter, Georg Rolshoven, Riham M. Idris, Herbert Zimmermann, Marianne Freundlieb, Aliaa Abdelrahman, Sang-Yong Lee, Christian Renn, Jan Pippel, Emma Scaletti, Christa E. Müller, Ali El-Tayeb
Publikováno v:
Journal of Medicinal Chemistry. 63:2941-2957
CD73 inhibitors are promising drugs for the (immuno)therapy of cancer. Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor α,β-methylene-ADP (AOPCP) subst
Autor:
Michael S. Wolfe, Minli Xing, Kathleen M. Meneely, Justin T. Douglas, Sujan Devkota, Sanjay Bhattarai
Publikováno v:
J Am Chem Soc
γ-Secretase is a membrane-embedded aspartyl protease complex central in biology and medicine. How this enzyme recognizes transmembrane substrates and catalyzes hydrolysis in the lipid bilayer is unclear. Inhibitors that mimic the entire substrate tr
Publikováno v:
Bioorg Med Chem Lett
A series of analogs based on a prototype aryl aminothiazole γ-secretase modulator (GSM) were synthesized and tested for their effects on the profile of 37-to-42-residue amyloid β-peptides (Aβ), generated through processive proteolysis of precursor