Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Sanjay A. Desai"'
Publikováno v:
Microorganisms, Vol 12, Iss 6, p 1172 (2024)
Malaria parasites increase their host erythrocyte’s permeability to obtain essential nutrients from plasma and facilitate intracellular growth. In the human Plasmodium falciparum pathogen, this increase is mediated by the plasmodial surface anion c
Externí odkaz:
https://doaj.org/article/e57dbf8061a8417092f37e19d9d5d08c
Autor:
Sanjay A. Desai
Publikováno v:
Genes, Vol 15, Iss 3, p 296 (2024)
Ion channels serve many cellular functions including ion homeostasis, volume regulation, signaling, nutrient acquisition, and developmental progression. Although the complex life cycles of malaria parasites necessitate ion and solute flux across memb
Externí odkaz:
https://doaj.org/article/598f8835ddcd49c0b70931d4bd1e1eb6
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-7 (2021)
Abstract Background Molecular and genetic studies of blood-stage Plasmodium falciparum parasites require limiting dilution cloning and prolonged cultivation in microplates. The entire process is laborious and subject to errors due to inaccurate dilut
Externí odkaz:
https://doaj.org/article/50c1c3a57b3643f39947d1fd07117f16
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Intracellular malaria parasites export many proteins into their host cell, inserting several into the erythrocyte plasma membrane to enable interactions with their external environment. While static techniques have identified some surface-ex
Externí odkaz:
https://doaj.org/article/f5f475e884134f76becf278a5418e12a
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically
Externí odkaz:
https://doaj.org/article/e7849785bfd748c59b3518f5cb0ac29a
Diverse target gene modifications in Plasmodium falciparum using Bxb1 integrase and an intronic attB
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-8 (2018)
Abstract Genetic manipulation of the human malaria parasite Plasmodium falciparum is needed to explore pathogen biology and evaluate antimalarial targets. It is, however, aggravated by a low transfection efficiency, a paucity of selectable markers an
Externí odkaz:
https://doaj.org/article/7e6ecd515e6e4a8693cd77cb3944f36a
Autor:
Moaz Ahmad, Javier Manzella-Lapeira, Gagandeep Saggu, Daisuke Ito, Joseph A. Brzostowski, Sanjay A. Desai
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Malaria parasites increase their host erythrocyte’s permeability to various nutrients, fueling intracellular pathogen development and replication. The plasmodial surface anion channel (PSAC) mediates this uptake and is linked to the parasi
Externí odkaz:
https://doaj.org/article/4efcaa676c4942f39b89dfc626ceb3f7
Autor:
Ankit Gupta, Praveen Balabaskaran-Nina, Wang Nguitragool, Gagandeep S. Saggu, Marc A. Schureck, Sanjay A. Desai
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Malaria parasites increase host erythrocyte permeability to ions and nutrients via a broad-selectivity channel known as the plasmodial surface anion channel (PSAC), linked to parasite-encoded CLAG3 and two associated proteins. These proteins
Externí odkaz:
https://doaj.org/article/bc49f608e99b45b6ae1ca729b4b9a946
Autor:
Ankit Gupta, Praveen Balabaskaran-Nina, Wang Nguitragool, Gagandeep S. Saggu, Marc A. Schureck, Sanjay A. Desai
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
Externí odkaz:
https://doaj.org/article/751e55f2923f4aab845a417c37a36adc
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Drugs represent the primary treatment available for human malaria, as caused by Plasmodium spp. Currently approved drugs and antimalarial drug leads generally work against parasite enzymes or activities within infected erythrocytes. To reach their sp
Externí odkaz:
https://doaj.org/article/323409c4712b4201b0ec29c9720fc060