Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Sanjay A Desai"'
Autor:
Padmapriya Sekar, Sumati Rajagopalan, Estela Shabani, Usheer Kanjee, Marc A Schureck, Gunjan Arora, Mary E Peterson, Boubacar Traore, Peter D Crompton, Manoj T Duraisingh, Sanjay A Desai, Eric O Long
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011585 (2023)
Natural killer (NK) cells lyse virus-infected cells and transformed cells through polarized delivery of lytic effector molecules into target cells. We have shown that NK cells lyse Plasmodium falciparum-infected red blood cells (iRBC) via antibody-de
Externí odkaz:
https://doaj.org/article/aff072e252f94230992a43f271b45acd
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283776 (2023)
The intracellular human malaria parasite, Plasmodium falciparum, uses the PfATP4 cation pump to maintain Na+ and H+ homeostasis in parasite cytosol. PfATP4 is the target of advanced antimalarial leads, which produce many poorly understood metabolic d
Externí odkaz:
https://doaj.org/article/c14db2fdf4594ea09651714cbd02595f
Autor:
Marc A Schureck, Joseph E Darling, Alan Merk, Jinfeng Shao, Geervani Daggupati, Prakash Srinivasan, Paul Dominic B Olinares, Michael P Rout, Brian T Chait, Kurt Wollenberg, Sriram Subramaniam, Sanjay A Desai
Publikováno v:
eLife, Vol 10 (2021)
Malaria parasites use the RhopH complex for erythrocyte invasion and channel-mediated nutrient uptake. As the member proteins are unique to Plasmodium spp., how they interact and traffic through subcellular sites to serve these essential functions is
Externí odkaz:
https://doaj.org/article/da19fed0a9f244e489c10d2cf3ae9a97
Autor:
Ankit Gupta, Abdullah A B Bokhari, Ajay D Pillai, Anna K Crater, Jeanine Gezelle, Gagandeep Saggu, Armiyaw S Nasamu, Suresh M Ganesan, Jacquin C Niles, Sanjay A Desai
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008363 (2020)
Malaria parasites activate a broad-selectivity ion channel on their host erythrocyte membrane to obtain essential nutrients from the bloodstream. This conserved channel, known as the plasmodial surface anion channel (PSAC), has been linked to parasit
Externí odkaz:
https://doaj.org/article/3c19b17cb5a94ec9bfe75408b3e3baa1
Autor:
Gunjan Arora, Geoffrey T Hart, Javier Manzella-Lapeira, Justin YA Doritchamou, David L Narum, L Michael Thomas, Joseph Brzostowski, Sumati Rajagopalan, Ogobara K Doumbo, Boubacar Traore, Louis H Miller, Susan K Pierce, Patrick E Duffy, Peter D Crompton, Sanjay A Desai, Eric O Long
Publikováno v:
eLife, Vol 7 (2018)
Antibodies acquired naturally through repeated exposure to Plasmodium falciparum are essential in the control of blood-stage malaria. Antibody-dependent functions may include neutralization of parasite–host interactions, complement activation, and
Externí odkaz:
https://doaj.org/article/457a8813d81c4843847f41ab69e26c6a
Publikováno v:
eLife, Vol 6 (2017)
Malaria parasites evade immune detection by growth and replication within erythrocytes. After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of nutrients from plasma. Here, we report that the parasite-encoded RhopH co
Externí odkaz:
https://doaj.org/article/ab53a0d863ae465c9fc83078c9735f20
Autor:
Margaret Pain, Alexandra W Fuller, Katherine Basore, Ajay D Pillai, Tsione Solomon, Abdullah A B Bokhari, Sanjay A Desai
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149214 (2016)
Malaria parasites increase their host erythrocyte's permeability to a broad range of ions and organic solutes. The plasmodial surface anion channel (PSAC) mediates this uptake and is an established drug target. Development of therapies targeting this
Externí odkaz:
https://doaj.org/article/51d74942f1bc45bf946b01abd7e7bbef
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93759 (2014)
The plasmodial surface anion channel mediates uptake of nutrients and other solutes into erythrocytes infected with malaria parasites. The clag3 genes of P. falciparum determine this channel's activity in human malaria, but how the encoded proteins c
Externí odkaz:
https://doaj.org/article/b610ba9304434b8d8e1eb9800b2cce85
Publikováno v:
European Biophysics Journal. 52:101-110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47a1bdfae3a4c2e3c909057f04621e6b
https://doi.org/10.1007/s00249-022-01623-y
https://doi.org/10.1007/s00249-022-01623-y
Autor:
Elroy Saldanha, Sanjay M. Desai, Dhruv G. Patel, Vinod Dhakad, Bonny Joseph, Sandeep Ghosh, Varun Prakash, Harsha Deepti, Ashma Monteiro
Publikováno v:
South Asian Journal of Cancer. 12:074-080
Objectives Epithelial ovarian cancer (EOC) is a heterogeneous, essentially peritoneal disease. Standard treatment consists of staging, cytoreductive surgery (CRS), and adjuvant chemotherapy. In this study, we intended to assess the effectiveness of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d6546d54b1f37da2e02ea2fd2ec2d6e
https://doi.org/10.1055/s-0042-1751098
https://doi.org/10.1055/s-0042-1751098