Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Sanjay, Ram"'
Autor:
Peter T. Beernink, Cristina Di Carluccio, Roberta Marchetti, Linda Cerofolini, Sara Carillo, Alessandro Cangiano, Nathan Cowieson, Jonathan Bones, Antonio Molinaro, Luigi Paduano, Marco Fragai, Benjamin P. Beernink, Sunita Gulati, Jutamas Shaughnessy, Peter A. Rice, Sanjay Ram, Alba Silipo
Publikováno v:
JACS Au, Vol 4, Iss 7, Pp 2617-2629 (2024)
Externí odkaz:
https://doaj.org/article/3b78fa31925743b98c78dd295a7f23ec
Autor:
Stian Foss, Siri A. Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, Diane B. Bratlie, Terje E. Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette Leusen, Thomas Valerius, Sanjay Ram, Suzan H. M. Rooijakkers, Inger Sandlie, Jan Terje Andersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dos
Externí odkaz:
https://doaj.org/article/e2bf31ade1774fb9ab1a7bfa70490845
Autor:
Smrithi S. Menon, Galia Ramirez-Toloza, Keith L. Wycoff, Sean Ehinger, Jutamas Shaughnessy, Sanjay Ram, Viviana P. Ferreira
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T. cruzi is highly resistant to killing by the complement immune system
Externí odkaz:
https://doaj.org/article/3047238984774b099d5e0b38bcbabb1d
Autor:
Sheri L. Peterson, Anitha Krishnan, Diyan Patel, Ali Khanehzar, Amit Lad, Jutamas Shaughnessy, Sanjay Ram, David Callanan, Derek Kunimoto, Mohamed A. Genead, Michael J. Tolentino
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 517 (2024)
The alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD). Complement depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, w
Externí odkaz:
https://doaj.org/article/43f2d905e6624be6a4ed977d1f6bf689
Autor:
Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B. DeOliveira, Jutamas Shaughnessy, Lisa A. Lewis, Peter A. Rice, Pär Comstedt, Sanjay Ram
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTA safe and effective vaccine is urgently needed to combat the global threat of multidrug-resistant (MDR) Neisseria gonorrhoeae. We screened 26 gonococcal proteins discovered by an artificial intelligence-driven platform called Efficacy Discri
Externí odkaz:
https://doaj.org/article/04fed7bbb74b447cb687510aff5f200b
Autor:
Shea K. Roe, Brian Felter, Bo Zheng, Sanjay Ram, Lee M. Wetzler, Eric Garges, Tianmou Zhu, Caroline A. Genco, Paola Massari
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1846 (2023)
Gonorrhea, a sexually transmitted disease caused by Neisseria gonorrhoeae, poses a significant global public health threat. Infection in women can be asymptomatic and may result in severe reproductive complications. Escalating antibiotic resistance u
Externí odkaz:
https://doaj.org/article/80dc3c05003f447cb5bb993ac31ed948
Autor:
Jutamas Shaughnessy, Aleyo Chabeda, Y. Tran, Bo Zheng, Nancy Nowak, Carolynn Steffens, Rosane B. DeOliveira, Sunita Gulati, Lisa A. Lewis, James Maclean, John A. Moss, Keith L. Wycoff, Sanjay Ram
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Novel therapeutics against the global threat of multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococci evade killing by complement by binding factor H (FH), a key inhibitor of the alternative pathway. FH comprises 20 short consensus
Externí odkaz:
https://doaj.org/article/f3abdcbc9c494fb6ab5c5b211e92670a
Autor:
Serena Bettoni, Karolina Maziarz, M Rhia L Stone, Mark A T Blaskovich, Jan Potempa, Maria Luiza Bazzo, Magnus Unemo, Sanjay Ram, Anna M. Blom
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neisseria gonorrhoeae is the etiological agent of gonorrhea, the second most common bacterial sexually transmitted infection worldwide. Reproductive sequelae of gonorrhea include infertility, ectopic pregnancy and chronic pelvic pain. Most antibiotic
Externí odkaz:
https://doaj.org/article/03c7d679788e4513a54e468ecd9f8a56
Autor:
Thomas M Hart, Alan P Dupuis, Danielle M Tufts, Anna M Blom, Simon R Starkey, Ryan O M Rego, Sanjay Ram, Peter Kraiczy, Laura D Kramer, Maria A Diuk-Wasser, Sergios-Orestis Kolokotronis, Yi-Pin Lin
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009801 (2021)
Pathogens possess the ability to adapt and survive in some host species but not in others-an ecological trait known as host tropism. Transmitted through ticks and carried mainly by mammals and birds, the Lyme disease (LD) bacterium is a well-suited m
Externí odkaz:
https://doaj.org/article/68672783203d4a3f87d1b1bdb4c9c048
Autor:
Elizabeth M. Parzych, Sunita Gulati, Bo Zheng, Mamadou A. Bah, Sarah T. C. Elliott, Jacqueline D. Chu, Nancy Nowak, George W. Reed, Frank J. Beurskens, Janine Schuurman, Peter A. Rice, David B. Weiner, Sanjay Ram
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Neisseria gonorrhoeae
Externí odkaz:
https://doaj.org/article/f8a963212313460cb9282d3601ffc0c2