Feasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma – protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial

Autor: Khalid Hamandi, Julie Woodfield, Smriti Agarwal, Richard Edwards, John Williamson, Ravindran Visagan, Rustam Al-Shahi Salman, Howard Brydon, Diederik Bulters, Dawn Hennigan, Paul Leach, Conor Mallucci, Nitin Mukerji, Marios Papadopoulos, Nicholas Ross, Martin Tisdall, Carole Turner, Shungu Ushewokunze, Raghu Vindlacheruvu, Paul Brennan, Phil White, Sophie Hunter, Karen Coy, Julia Wade, James Stewart, Tom Hughes, Laura Forsyth, Kirsty Harkness, David White, Rupal Shah, Sanjay Bhate, Neil Kitchen, Peter J Hutchinson, Emanuel Cirstea, Ramesh Nair, Rebecca Hall, Varduhi Cahill, Tom Hayton, Silvia Tarantino, Christin Eltze, Jack Lee, Arlo Whitehouse, Daniel Walsh, Jacqueline Stephen, Nicola Phillips, Steff Lewis, Susan Davies, Mathew Guilfoyle, Peter S Hall, Andrew Stoddart, Francesca Colombo, Emma Richards, Greg James, Sarah Illingworth, William B Lo, Andrew Bacon, Vijeya Ganesan, Sabina Patel, Aileen R Neilson, Felicia Jennings, Saba Raza-Knight, Andrew Brodbelt, Aswin Chari, Hasan Asif, Ian Kamaly-Asl, Milan Makwana, Zubair Tahir, Allan MacRaild, Grace Vassallo, Ian Anderson, Daniel Holsgrove, Carole Chambers, Sandra Williams, Francesca Spickett-Jones, Marios C Papadopoulos, John Preston, Edward White, Adel Helmy, Sarah Ali, John Reid, Daniel Brown, Louis Taylor, Christopher Uff, Patrick Grover, Azra Banaras, Linetty Makawa, Anil Israni, Richard J Edwards, William Muirhead, Daniel Brooks, Debbie Brown, Ciaran Scott Hill, Kerry Smith, Beth Atkinson, Michelle Fawcett, Sifelani Tshuma, Oliver Kennion, Jo Howe, James J M Loan, Philip Clatworthy, Claire Hudson, Rebecca Hodnett, Madalina Roman, Mary Sikaonga, Elaine Kinsella, Mario Teo, Venetia Giannakaki, James Loan, Lauren Harris, Jack Wildman, Emmanuel Chavredakis, Nihal Gurusinghe, Alex Rossdeutsch, Anthony Wiggins, Giannis Sokratous, Lucie Ferguson, Shakeelah Patel, Sonia Raj, Oishik Raha, Janneke van Beijnum, Pragnesh Bhatt, Anna Bjornson, Nicole Broomes, Alistair Bullen, Julian Cahill, Mihai Danciut, Ronneil Digpal, Ioannis Fouyas, Lauren S Harris, Sohail Majeed, Matthias Radatz, Oliver Wroe Wright, Jessica Teasdale, Michelle Coakley, Drahoslav Sokol, Chandru Kaliaperumal, Mairi MacDonald, Sarah Risbridger, Siobhan Kearney, Ellaine Bosetta, Thomas Doke, Sonny Coskuner, Christine Kamara, Jonathan Gardner, Imron Hamina, Kishor Chaudhari, Liliana Chapas, Karen Caldwell, Sarah Holland, Tamara Tajsic, Rachael Dore, Taya Anderson, Shelley Mayor, Laura O'Malley, Samantha Glover, Janice Irvine, Annika Walch, Farah Muir, Eng Tah Goh, Andrew McDarby, Michelle Bates, Rebecca Hancox, Claudia Kate Auyeung, Elizabeth Goff, Deanna Stephens, Borislava Borislavova, Ruth Worner, Sandeep Buddha, Lisa Tucker, Sandra Dymond, Andrew Mallick, Dymona McAleer, Belinda Gunning, Emma Clarkson, Cathy Stoneley, Jibril Osman Farah, Niamh Bohnacker, Rosette Marimon, Lydia Parker, Puneet Sharma, Dan Holsgrove, Danielle McLaughlan, Tracey Marsden, Kathryn Cawley, Hellen Raffalli, Imedla Mayor, Dipek Ram, Rebecca Keeping, Katie Hennessy, Ammar Kadhim, Md Moidul Islam, Manjunath Prasad, Cheryl Webster, Vicky Slater, Saffnan Mohamed, Saba Raza Knight, Terri-Louise Cromie, Allan Brown, Ruth Pennington, Charlene Campbell, Anthony Ghosh, Teresa Fitzpatrick, Mohammed Patel, Winnington Ruiz, Mirriam Taylor, Divina Anyog, Katarzyna Tluchowska, Jackson Nolasco, Kleopatra Angelopoulou, Bethany Welch, Ida Ponce, Lucy Bailey, Mia Marsden, Angelene Cope, Deepthy Blesson, Rachel Sutton, Mary Kambafwile, Jade McAndrew

Publikováno v: BMJ Open, Vol 13, Iss 8 (2023)

Introduction The top research priority for cavernoma, identified by a James Lind Alliance Priority setting partnership was ‘Does treatment (with neurosurgery or stereotactic radiosurgery) or no treatment improve outcome for people diagnosed with a

Externí odkaz: https://doaj.org/article/df389aa5a29f4557ac19c817e505e753

Neurosurgical management of proton beam therapy–induced moyamoya syndrome

Autor: Catherine H. Zhang, William Muirhead, Adikarige H. D. Silva, Claire Toolis, Fergus Robertson, Adam Rennie, Sanjay Bhate, Dominic N. P. Thompson, Vijeya Ganesan, Greg James

Publikováno v: Journal of Neurosurgery: Pediatrics. 31:369-379

OBJECTIVE Proton beam therapy (PBT) is an increasingly used treatment modality for pediatric patients with brain tumors. Moyamoya syndrome (MMS) is well recognized as a complication of traditional photon radiotherapy, however its association with PBT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00dad90a478cbe09846f193804914687
https://doi.org/10.3171/2022.12.peds22423

Surgical revascularization for pediatric moyamoya: the role of surgical mentorship in sustaining and developing a neurovascular service

Autor: Adikarige Haritha Dulanka Silva, Sanjay Bhate, Vijeya Ganesan, Dominic Thompson, Greg James

Publikováno v: Journal of Neurosurgery: Pediatrics. 30:89-98

OBJECTIVE Obtaining operative experience for the treatment of rare conditions in children represents a challenge for pediatric neurosurgeons. Starting in November 2017, a surgeon was mentored in surgical revascularization (SR) for pediatric moyamoya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed26358ed20368554f6b33b572cff33
https://doi.org/10.3171/2022.3.peds21590

Diagnosing Mitochondrial Disorders Remains Challenging in the Omics Era

Autor: Cathy E. Woodward, Thomas S. Jacques, Paul Gissen, Simon Heales, Jane A. Hurst, Richard H Scott, Emma Footitt, Sanjay Bhate, Shamima Rahman, James Davison, Stephanie Grunewald, Patrick Forny, Thomas Cullup, Spyros Batzios, Maureen Cleary, Anupam Chakrapani, Amanda Lam

Publikováno v: Neurology: Genetics
article-version (Version of Record) 3

ObjectiveWe hypothesized that novel investigative pathways are needed to decrease diagnostic odysseys in pediatric mitochondrial disease and sought to determine the utility of clinical exome sequencing in a large cohort with suspected mitochondrial d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2ecd758f352e03720a9923f82e4dc3
https://pubmed.ncbi.nlm.nih.gov/34056100

Diagnostic algorithm for children presenting with epilepsia partialis continua

Autor: Catherine DeVile, Christin Eltze, Yael Hacohen, Thomas Rossor, Jane Hassell, Robert Robinson, Prab Prabhakar, Sarah E. Aylett, Finbar O'Callaghan, Krishna B. Das, Sophia Varadkar, Stewart Boyd, Lucinda Carr, Marios Kaliakatsos, Sanjay Bhate, Felice D'Arco, J. Helen Cross, Snehal Surana, Cheryl Hemingway

Publikováno v: EpilepsiaREFERENCES. 61(10)

OBJECTIVE To characterize a cohort of children with epilepsia partialis continua (EPC) and develop a diagnostic algorithm incorporating key differential diagnoses. METHODS Children presenting with EPC to a tertiary pediatric neurology center between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35af58767b669c15699266e17b2d542f
https://pubmed.ncbi.nlm.nih.gov/32875551