Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Sanjay, Bhanot"'
Autor:
Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras, Patricia Aspichueta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.
Externí odkaz:
https://doaj.org/article/679efae112224ba6a2829203d49df6dc
Autor:
Michael Walsh, Claudette Bethune, Andrew Smyth, Jessica Tyrwhitt, Shiangtung W. Jung, Rosie Z. Yu, Yanfeng Wang, Richard S. Geary, Jeffrey Weitz, Sanjay Bhanot
Publikováno v:
Kidney International Reports, Vol 7, Iss 2, Pp 200-209 (2022)
Introduction: Patients with end-stage renal disease (ESRD) requiring hemodialysis (HD) have an increased risk of thrombotic events and bleeding. Antisense reduction of factor XI (FXI) with IONIS-FXIRx is a novel strategy that may safely reduce the ri
Externí odkaz:
https://doaj.org/article/9d5c672fdff6474baf02354f5b056319
Autor:
Stefan Willmann, Eleonora Marostica, Nelleke Snelder, Alexander Solms, Markus Jensen, Maximilian Lobmeyer, Anthonie W. A. Lensing, Claudette Bethune, Erin Morgan, Rosie Z. Yu, Yanfeng Wang, Shiangtung W. Jung, Richard Geary, Sanjay Bhanot
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 890-901 (2021)
Abstract IONIS‐FXIRX (BAY2306001) is an antisense oligonucleotide that inhibits the synthesis of coagulation factor XI (FXI) and has been investigated in healthy volunteers and patients with end‐stage renal disease (ESRD). FXI‐LICA (BAY2976217)
Externí odkaz:
https://doaj.org/article/a0f07a9e368749df85e58f6529f928d9
Autor:
Daniel Lindén, Andrea Ahnmark, Piero Pingitore, Ester Ciociola, Ingela Ahlstedt, Anne-Christine Andréasson, Kavitha Sasidharan, Katja Madeyski-Bengtson, Magdalena Zurek, Rosellina M. Mancina, Anna Lindblom, Mikael Bjursell, Gerhard Böttcher, Marcus Ståhlman, Mohammad Bohlooly-Y, William G. Haynes, Björn Carlsson, Mark Graham, Richard Lee, Sue Murray, Luca Valenti, Sanjay Bhanot, Peter Åkerblad, Stefano Romeo
Publikováno v:
Molecular Metabolism, Vol 22, Iss , Pp 49-61 (2019)
Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributo
Externí odkaz:
https://doaj.org/article/f77b71978d104e8aa87a52faaeaa4522
Autor:
Brenda F. Baker, Shuting Xia, Wesley Partridge, T. Jesse Kwoh, Sotirios Tsimikas, Sanjay Bhanot, Richard S. Geary
Publikováno v:
Nucleic Acid Therapeutics. 33:72-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54dc571f4f0996da54a23f710d864e2f
https://doi.org/10.1089/nat.2022.0044
https://doi.org/10.1089/nat.2022.0044
Autor:
Patricia Aspichueta, Ana M. Zubiaga, Luis Castaño, Maria L. Martínez-Chantar, Jesus M. Banales, Javier Crespo, Paula Iruzubieta, Idoia Martinez de la Piscina, Sonia Gaztambide, Lorena Mosteiro, Gaizka Errazti, Maria J. Perugorria, Igotz Delgado, Sanjay Bhanot, Richard Lee, Naroa Goikoetxea-Usandizaga, Teresa C. Delgado, Virginia Gutierrez De Juan, Irantzu Bernales, Ainhoa Iglesias-Ara, Xabier Buqué, Larraitz Fernández-Ares, Juan L. García-Rodríguez, Maitane Núñez-García, Diego Sáenz de Urturi, Beatriz Gómez-Santos, Marta Palomo-Irigoyen, Marta Varela-Rey, Miguel Tamayo-Caro, Ashwin Woodhoo, Jesper B. Andersen, Colm J. O'Rourke, Igor Aurrekoetxea, Daniela Mestre, Francisco González-Romero
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddf213946fc87fd4f283ab64b4cde07
https://doi.org/10.1158/0008-5472.22430244
https://doi.org/10.1158/0008-5472.22430244
Autor:
Patricia Aspichueta, Ana M. Zubiaga, Luis Castaño, Maria L. Martínez-Chantar, Jesus M. Banales, Javier Crespo, Paula Iruzubieta, Idoia Martinez de la Piscina, Sonia Gaztambide, Lorena Mosteiro, Gaizka Errazti, Maria J. Perugorria, Igotz Delgado, Sanjay Bhanot, Richard Lee, Naroa Goikoetxea-Usandizaga, Teresa C. Delgado, Virginia Gutierrez De Juan, Irantzu Bernales, Ainhoa Iglesias-Ara, Xabier Buqué, Larraitz Fernández-Ares, Juan L. García-Rodríguez, Maitane Núñez-García, Diego Sáenz de Urturi, Beatriz Gómez-Santos, Marta Palomo-Irigoyen, Marta Varela-Rey, Miguel Tamayo-Caro, Ashwin Woodhoo, Jesper B. Andersen, Colm J. O'Rourke, Igor Aurrekoetxea, Daniela Mestre, Francisco González-Romero
Lipid metabolism rearrangements in nonalcoholic fatty liver disease (NAFLD) contribute to disease progression. NAFLD has emerged as a major risk for hepatocellular carcinoma (HCC), where metabolic reprogramming is a hallmark. Identification of metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a5c6a7e5944231bd4c670412d55b9a1
https://doi.org/10.1158/0008-5472.c.6513576.v1
https://doi.org/10.1158/0008-5472.c.6513576.v1
Autor:
Patricia Aspichueta, Ana M. Zubiaga, Luis Castaño, Maria L. Martínez-Chantar, Jesus M. Banales, Javier Crespo, Paula Iruzubieta, Idoia Martinez de la Piscina, Sonia Gaztambide, Lorena Mosteiro, Gaizka Errazti, Maria J. Perugorria, Igotz Delgado, Sanjay Bhanot, Richard Lee, Naroa Goikoetxea-Usandizaga, Teresa C. Delgado, Virginia Gutierrez De Juan, Irantzu Bernales, Ainhoa Iglesias-Ara, Xabier Buqué, Larraitz Fernández-Ares, Juan L. García-Rodríguez, Maitane Núñez-García, Diego Sáenz de Urturi, Beatriz Gómez-Santos, Marta Palomo-Irigoyen, Marta Varela-Rey, Miguel Tamayo-Caro, Ashwin Woodhoo, Jesper B. Andersen, Colm J. O'Rourke, Igor Aurrekoetxea, Daniela Mestre, Francisco González-Romero
1-Supplementary methods 2-Supplementary Figure legends 3-Supplementary references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c113bd0a2cdcb35d220f3dc823b4840
https://doi.org/10.1158/0008-5472.22430247.v1
https://doi.org/10.1158/0008-5472.22430247.v1
Autor:
Arvindhan Nagarajan, Max C. Petersen, Ali R. Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J. Jurczak, Michael R. Green, Gerald I. Shulman, Narendra Wajapeyee
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and, th
Externí odkaz:
https://doaj.org/article/5e20ff02ef4b4bf79837c323cd66c1bb
Autor:
Brenda F. Baker, Shuting Xia, Wesley Partridge, Richard S. Geary, Sanjay Bhanot, T. Jesse Kwoh
Publikováno v:
Nucleic Acid Therapeutics
The development process of antisense oligonucleotides (ASOs) as therapeutic agents in humans has advanced through the implementation of chemical compound modifications as well as increasingly sophisticated toxicological preclinical screening techniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a15be03ddcace5a4a9c8c879eb0520
https://doi.org/10.1089/nat.2020.0917
https://doi.org/10.1089/nat.2020.0917