Zobrazeno 1 - 10
of 578
pro vyhledávání: '"Sanjay, Asthana"'
Autor:
Kitty K. Lui, Abhishek Dave, Kate E. Sprecher, Miranda G. Chappel-Farley, Brady A. Riedner, Margo B. Heston, Chase E. Taylor, Cynthia M. Carlsson, Ozioma C. Okonkwo, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin, Bryce A. Mander, Ruth M. Benca
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid
Externí odkaz:
https://doaj.org/article/0ace0e428a314524b2ba362c438b75ac
Autor:
Filippo Martinelli, Almut Heinken, Ann-Kristin Henning, Maria A. Ulmer, Tim Hensen, Antonio González, Matthias Arnold, Sanjay Asthana, Kathrin Budde, Corinne D. Engelman, Mehrbod Estaki, Hans-Jörgen Grabe, Margo B. Heston, Sterling Johnson, Gabi Kastenmüller, Cameron Martino, Daniel McDonald, Federico E. Rey, Ingo Kilimann, Olive Peters, Xiao Wang, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Matthias Nauck, Stefan Teipel, Rob Knight, Rima F. Kaddurah-Daouk, Barbara B. Bendlin, Johannes Hertel, Ines Thiele
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract In this study, we aimed to understand the potential role of the gut microbiome in the development of Alzheimer's disease (AD). We took a multi-faceted approach to investigate this relationship. Urine metabolomics were examined in individuals
Externí odkaz:
https://doaj.org/article/9445c1dce1a8438ba72e79a6a96af1f9
Autor:
Carol Van Hulle, Selvi Ince, Ozioma C. Okonkwo, Barbara B. Bendlin, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Seth Love, Kaj Blennow, Henrik Zetterberg, J. Scott Miners
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Breakdown of the neurovascular unit is associated with blood-brain barrier (BBB) leakiness contributing to cognitive decline and disease pathology in the early stages of Alzheimer’s disease (AD). Vascular stability depends on angiopoietin-
Externí odkaz:
https://doaj.org/article/e810f28aac8941cab385eb1aa712f3ca
Autor:
Margo B. Heston, Kendra L. Hanslik, Katie R. Zarbock, Sandra J. Harding, Nancy J. Davenport-Sis, Robert L. Kerby, Nathaniel Chin, Yi Sun, Ana Hoeft, Yuetiva Deming, Nicholas M. Vogt, Tobey J. Betthauser, Sterling C. Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Norbert Wild, Henrik Zetterberg, Kaj Blennow, Federico E. Rey, Barbara B. Bendlin, Tyler K. Ulland
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Age-related disease may be mediated by low levels of chronic inflammation (“inflammaging”). Recent work suggests that gut microbes can contribute to inflammation via degradation of the intestinal barrier. While aging and age-related dise
Externí odkaz:
https://doaj.org/article/506736e3f4d7449a8334c7f95494e88c
Autor:
Rigina L. Gallagher, Rebecca Langhough Koscik, Jason F. Moody, Nicholas M. Vogt, Nagesh Adluru, Steven R. Kecskemeti, Carol A. Van Hulle, Nathaniel A. Chin, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Cynthia M. Carlsson, Sterling C. Johnson, Douglas C. Dean, Henrik Zetterberg, Kaj Blennow, Andrew L. Alexander, Barbara B. Bendlin
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Alzheimer’s disease involves accumulating amyloid (A) and tau (T) pathology, and progressive neurodegeneration (N), leading to the development of the AD clinical syndrome. While several markers of N have been proposed, efforts t
Externí odkaz:
https://doaj.org/article/c04adba2c3e445aa841cb5eec1418033
Autor:
Gilda E. Ennis, Tobey J. Betthauser, Rebecca Langhough Koscik, Nathaniel A. Chin, Bradley T. Christian, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Insulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer’s clinical syndrome in epidemiologic studies but have not been associated with tau tangles in neuropathological research and have bee
Externí odkaz:
https://doaj.org/article/c71ca052ae204c339663ead5d216a974
Autor:
Ruocheng Dong, Qiongshi Lu, Hyunseung Kang, Ivonne Suridjan, Gwendlyn Kollmorgen, Norbert Wild, Yuetiva Deming, Carol A. Van Hulle, Rozalyn M. Anderson, Henrik Zetterberg, Kaj Blennow, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, Corinne D. Engelman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionMetabolomics technology facilitates studying associations between small molecules and disease processes. Correlating metabolites in cerebrospinal fluid (CSF) with Alzheimer’s disease (AD) CSF biomarkers may elucidate additional changes
Externí odkaz:
https://doaj.org/article/d7468cb3c4aa4e4b8ca39bbe2a7806d5
Autor:
Barbara Fischer, Carol Ann Van Hulle, Rebecca Langhough, Derek Norton, Megan Zuelsdorff, Diane Carol Gooding, Mary F. Wyman, Adrienne Johnson, Nickolas Lambrou, Taryn James, Shenikqua Bouges, Fabu Phillis Carter, Hector Salazar, Kristopher Kirmess, Mary Holubasch, Matthew Meyer, Venky Venkatesh, Tim West, Philip Verghese, Kevin Yarasheski, Cynthia M. Carlsson, Sterling C. Johnson, Sanjay Asthana, Carey E. Gleason
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 3, Pp n/a-n/a (2023)
Abstract Introduction It is critical to develop more inclusive Alzheimer's disease (AD) research protocols to ensure that historically excluded groups are included in preclinical research and have access to timely diagnosis and treatment. If validate
Externí odkaz:
https://doaj.org/article/eb13fdc76b2f4597a4d569cd5d18a274
Autor:
Nicholas M. Vogt, Jack F. V. Hunt, Yue Ma, Carol A. Van Hulle, Nagesh Adluru, Richard J. Chappell, Karen K. Lazar, Laura E Jacobson, Benjamin P. Austin, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin, Cynthia M. Carlsson
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1656-1667 (2021)
Abstract Background The brain is the most cholesterol‐rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol‐lowing medications used by millions of adults for prevention of vascular disease, yet the effect o
Externí odkaz:
https://doaj.org/article/03af5eeaf0bd408c900b904e4a23acba
Autor:
Mary F. Wyman, Carol A. Van Hulle, Emre Umucu, Sydnee Livingston, Nickolas H. Lambrou, Fabu P. Carter, Sterling C. Johnson, Sanjay Asthana, Carey E. Gleason, Megan Zuelsdorff
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
Psychological well-being is associated with cognition in later life but has not been examined across diverse populations—including minoritized communities at disproportionately high risk of dementia. Further, most previous work has not been able to
Externí odkaz:
https://doaj.org/article/09919b499e494aa78e7bf83952c4e548