Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sanjana Eyunni"'
Autor:
Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is depend
Externí odkaz:
https://doaj.org/article/4879439f815846169a9d5e62cae6d7c2
Autor:
Lanbo Xiao, Abhijit Parolia, Yuanyuan Qiao, Pushpinder Bawa, Sanjana Eyunni, Rahul Mannan, Sandra E. Carson, Yu Chang, Xiaoju Wang, Yuping Zhang, Josh N. Vo, Steven Kregel, Stephanie A. Simko, Andrew D. Delekta, Mustapha Jaber, Heng Zheng, Ingrid J. Apel, Lisa McMurry, Fengyun Su, Rui Wang, Sylvia Zelenka-Wang, Sanjita Sasmal, Leena Khare, Subhendu Mukherjee, Chandrasekhar Abbineni, Kiran Aithal, Mital S. Bhakta, Jay Ghurye, Xuhong Cao, Nora M. Navone, Alexey I. Nesvizhskii, Rohit Mehra, Ulka Vaishampayan, Marco Blanchette, Yuzhuo Wang, Susanta Samajdar, Murali Ramachandra, Arul M. Chinnaiyan
Publikováno v:
Nature
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling1 and is altered in over 20% of cancers2,3. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 an
Autor:
Abhijit Parolia, Lanbo Xiao, Yuanyuan Qiao, Pushpinder Bawa, Sanjana Eyunni, Eleanor Young, Rahul Mannan, Sandra E. Carson, Yu Chang, Yuping Zhang, James George, Mustapha Jaber, Fengyun Su, Rui Wang, Sanjita Sasmal, Leena Khare, Subhendu Mukerjee, Chandrasekhar AbbinenI, Kiran Aithal, Xuhong Cao, Yuzhuo Wang, Susanta Samajdar, Murali Ramachandra, Arul M. Chinnaiyan
Publikováno v:
Cancer Research. 82:3592-3592
In mammalian cells, DNA is wrapped around histone octamers (collectively referred to as nucleosomes) which form a physical barrier to all DNA-based processes. The switch/sucrose non-fermentable (SWI/SNF) is a multi-subunit chromatin remodeling comple
Autor:
Lanbo Xiao, Abhijit Parolia, Yuanyuan Qiao, Pushpinder Bawa Pushpinder, Sanjana Eyunni, Rahul Mannan, Sandra E. Carson, Yu Chang, Xiaoju Wang, Yuping Zhang, Josh Vo, Steven Kregel, Stephanie A. Simko, Andrew D. Delekta, Mustapha Jaber, Heng Zheng, Ingrid Apel, Lisa McMurry, Fengyun Su, Rui Wang, Sylvia Wang, Sanjita Sasmal, Leena K. Satyam, Subhendu Mukherjee, Chandrasekhar AbbinenI, Kiran Aithal, Mital S. Bhakta, Jay Ghurye, Xuhong Cao, Nora M. Navone, Alexey Nesvizhskii, Rohit Mehra, Ulka Vaishampayan, Marco Blanchette, Yuzhuo Wang, Susanta Samajdar, Murali Ramachandra, Arul M. Chinnaiyan
Publikováno v:
Cancer Research. 82:5469-5469
The switch/sucrose non-fermentable (SWI/SNF) complex plays a crucial role in chromatin remodeling and is recurrently altered in over 20% of human cancers. Here, we developed a proteolysis targeting chimera (PROTAC) degrader of ATPase subunits of the
Autor:
Ronald F. Siebenaler, Jean Ching-Yi Tien, Vijaya L. Dommeti, Rahul Mannan, Stephanie J. Ellison, Sethuramasundaram Pitchiaya, Xuhong Cao, Seema Chugh, Howard C. Crawford, Ingrid J. Apel, Jessica Waninger, Chandan Kumar-Sinha, Andrew Goodrum, Sanjana Eyunni, Sylvia Zelenka-Wang, Pankaj Vats, Yuping Zhang, Malay Mody, Jiaqi Shi, Xiaoming Wang, Alice Xu, Sunita Shankar, John J.G. Tesmer, Arul M. Chinnaiyan
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Both KRAS and EGFR are essential mediators of pancreatic cancer development and interact with Argonaute 2 (AGO2) to perturb its function. Here, in a mouse model of mutant KRAS-driven pancreatic cancer, loss of AGO2 allows precursor lesion (PanIN) for
Autor:
Vijaya L. Dommeti, Howard C. Crawford, Jiaqi Shi, Andrew Goodrum, Sylvia Zelenka-Wang, Ingrid J. Apel, Sanjana Eyunni, Ronald F. Siebenaler, Sethuramsundaram Pitchiaya, Sunita Shankar, Yuping Zhang, Xiaoming Wang, Javed Siddiqui, Jean Ching-Yi Tien, Arul M. Chinnaiyan, Kristin M. Juckette, Seema Chugh, Jessica Waninger, Chandan Kumar-Sinha, Xuhong Cao
Publikováno v:
Cancer Research. 80:2577-2577
KRAS mutations drive over 30% of all cancers and 90% of pancreatic cancer. To investigate additional potential modulators of RAS-mediated oncogenesis, we previously performed a screen for direct interactors of RAS in a panel of cancer cell lines and
Autor:
Jiaqi Shi, Andrew Goodrum, Vijaya L. Dommeti, John J.G. Tesmer, Alice Xu, Kristin M. Juckette, Sunita Shankar, Arul M. Chinnaiyan, Sanjana Eyunni, Xiaoming Wang, Malay Mody, Ronald F. Siebenaler, Yuping Zhang, Javed Siddiqui, Sylvia Zelenka-Wang, Grace Tsaloff, Jean Ching-Yi Tien, Xuhong Cao, Ingrid J. Apel, Richard D. Smith, Jessica Waninger, Chandan Kumar-Sinha, Lisha Wang, Seema Chugh, Heather A. Carlson
Publikováno v:
Molecular Cancer Research. 18:A20-A20
In 2016, we identified a direct interaction between RAS and Argonaute 2 (AGO2), a key mediator of RNA-mediated gene silencing that is required for KRAS-driven oncogenesis using pancreatic and lung cancer cell line models. Recently, we employed the ge
Autor:
Javed Siddiqui, Xiaoming Wang, Jiaqi Shi, Heather A. Carlson, Lisha Wang, Vijaya L. Dommeti, Ingrid J. Apel, Alice Xu, Seema Chugh, Grace Tsaloff, Sunita Shankar, Richard D. Smith, Sylvia Zelenka-Wang, John J.G. Tesmer, Jessica Waninger, Chandan Kumar-Sinha, Arul M. Chinnaiyan, Ronald F. Siebenaler, Andrew Goodrum, Howard C. Crawford, Sanjana Eyunni, Malay Mody, Kristin M. Juckette, Yuping Zhang, Jean Ching-Yi Tien, Xuhong Cao
KRAS and EGFR are known essential mediators of pancreatic cancer development. In addition, KRAS and EGFR have both been shown to interact with and perturb the function of Argonaute 2 (AGO2), a key regulator of RNA-mediated gene silencing. Here, we em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5649be3de14cf951f45f862dd09e6875
Autor:
Ronald F. Siebenaler, Sanjana Eyunni, Vijaya L. Dommeti, Kristin M. Juckette, Arul M. Chinnaiyan, Sylvia Z. Wang, Sunita Shankar, Lisha Wang, Seema Chugh, Jean C. Tien
Publikováno v:
Cancer Research. 79:94-94
Pancreatic cancer is a highly devastating malignancy with a very poor survival rate of 7%. Mutations in KRAS have been identified in more than 90% of PDAC patients. Previous work from our lab has shown that KRAS directly interacts with Argonaute 2 (A
Autor:
Heather A. Carlson, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Seema Chugh, Sanjana Eyunni, Malay Mody, Kristin M. Juckette, Ingrid J. Apel, Grace Tsaloff, Jiaqi Shi, Alice Xu, Arul M. Chinnaiyan, Richard D. Smith, John J.G. Tesmer, Jessica Waninger, Chandan Kumar-Sinha, Ronald F. Siebenaler, Xiaoming Wang, Andrew Goodrum, Javed Siddiqui, Jean Ching-Yi Tien, Xuhong Cao, Sunita Shankar, Yuping Zhang
Publikováno v:
Cancer Research. 79:957-957
In 2016, we identified a direct interaction between RAS and Argonaute 2 (AGO2), a key mediator of RNA-mediated gene silencing, that is essential for KRAS-driven oncogenesis using pancreatic and lung cancer cell line models. Recently, we employed a ge