Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sanja Pajovic"'
Autor:
Robert Siddaway, Scott Milos, Arun Kumaran Anguraj Vadivel, Tara H. W. Dobson, Jyothishmathi Swaminathan, Scott Ryall, Sanja Pajovic, Palak G. Patel, Javad Nazarian, Oren Becher, Michael Brudno, Arun Ramani, Vidya Gopalakrishnan, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Targeting genetic drivers of high grade diffuse glioma (HGG) has not improved patient survival, suggesting the involvement of other mechanisms. Here, across cancer types, the authors identify increased alternative splicing burden in cancer drivers co
Externí odkaz:
https://doaj.org/article/16682e61ebb34dd9b0ee5d0b70707f1e
Autor:
Sanja Pajovic, Robert Siddaway, Taylor Bridge, Javal Sheth, Patricia Rakopoulos, Byungjin Kim, Scott Ryall, Sameer Agnihotri, Lauren Phillips, Man Yu, Christopher Li, Scott Milos, Palak Patel, Dilakshan Srikanthan, Annie Huang, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate divers
Externí odkaz:
https://doaj.org/article/d2950e03eca24abe9198eff022010cfc
Autor:
Brigitte L Thériault, Halesha D Basavarajappa, Harvey Lim, Sanja Pajovic, Brenda L Gallie, Timothy W Corson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91540 (2014)
KIF14 (kinesin family member 14) is a mitotic kinesin and an important oncogene in several cancers. Tumor KIF14 expression levels are independently predictive of poor outcome, and in cancer cells KIF14 can modulate metastatic behavior by maintaining
Externí odkaz:
https://doaj.org/article/6e4c7415686e417395f53f09ee03dd34
Autor:
Mellone N Marchong, Christine Yurkowski, Clement Ma, Clarellen Spencer, Sanja Pajovic, Brenda L Gallie
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000923 (2010)
CDH11 gene copy number and expression are frequently lost in human retinoblastomas and in retinoblastomas arising in TAg-RB mice. To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with TAg-RB mice. Loss of Cdh11 had n
Externí odkaz:
https://doaj.org/article/0ab07be1f0084774ac2c9a032f9ae740
Autor:
Nadia L. Prigoda-Leea, Diane Rushlowa, Beata Piovesan, Katherine Zhang, Helen Dimaras, Sanja Pajovic, Brenda L. Galliea
Publikováno v:
Cellular Oncology, Vol 31, Iss 3, Pp 249-250 (2009)
Externí odkaz:
https://doaj.org/article/7fb8111d9b7f43b786650ae25d55624f
Autor:
Robert Siddaway, Laura Canty, Sanja Pajovic, Scott Milos, Etienne Coyaud, Stefanie-Grace Sbergio, Arun Kumaran Vadivel Anguraj, Evan Lubanszky, Hwa Young Yun, Alessia Portante, Sheyenne Carette, Cunjie Zhang, Michael F. Moran, Brian Raught, Eric I. Campos, Cynthia Hawkins
Publikováno v:
Acta Neuropathologica. 144:1027-1048
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations
Autor:
Cynthia Hawkins, Gelareh Zadeh, Peter B. Dirks, Chris Jones, James T. Rutka, Michael D. Taylor, Robert W. Sobol, Nesrin Sabha, Renee Head, Christian Ternamian, Sanja Pajovic, Mark S. Barszczyk, Ian D. Clarke, Nestor A. Fernandez, Aaron Gajadhar, Yevgen Chornenkyy, Brian Golbourn, Marc Remke, Pawel Buczkowicz, Kelly Burrell, Sameer Agnihotri
PDF file - 143KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab11dcf36dc534638261a497dfdc08b
https://doi.org/10.1158/2159-8290.22530770
https://doi.org/10.1158/2159-8290.22530770
Autor:
Cynthia Hawkins, Gelareh Zadeh, Peter B. Dirks, Chris Jones, James T. Rutka, Michael D. Taylor, Robert W. Sobol, Nesrin Sabha, Renee Head, Christian Ternamian, Sanja Pajovic, Mark S. Barszczyk, Ian D. Clarke, Nestor A. Fernandez, Aaron Gajadhar, Yevgen Chornenkyy, Brian Golbourn, Marc Remke, Pawel Buczkowicz, Kelly Burrell, Sameer Agnihotri
PDF file - 432KB, Supplementary Figure 1: Validation of Temozolomide (TMZ) siRNA Screen. Supplementary Figure 2: Base Excision Repair correlates with IC50 of alkylating agents. Supplementary Figure 3: Loss of MPG promotes sensitivity to alkylating ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062f65befb9707e77da27d3e709ac51d
https://doi.org/10.1158/2159-8290.22530773.v1
https://doi.org/10.1158/2159-8290.22530773.v1
Autor:
Cynthia Hawkins, Gelareh Zadeh, Peter B. Dirks, Chris Jones, James T. Rutka, Michael D. Taylor, Robert W. Sobol, Nesrin Sabha, Renee Head, Christian Ternamian, Sanja Pajovic, Mark S. Barszczyk, Ian D. Clarke, Nestor A. Fernandez, Aaron Gajadhar, Yevgen Chornenkyy, Brian Golbourn, Marc Remke, Pawel Buczkowicz, Kelly Burrell, Sameer Agnihotri
PDF file - 95KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01adb7513926c1c899b2416d1fab535d
https://doi.org/10.1158/2159-8290.22530776
https://doi.org/10.1158/2159-8290.22530776
Autor:
Etienne Coyaud, Sheyenne Carette, Haley Yun, Stefanie-Grace Sbergio, Sanja Pajovic, Robert Siddaway, Cynthia Hawkins, Scott Milos, Laura Canty, Alessia Portante, Brian Raught, Eric Campos, Evan Lubanszky
Publikováno v:
Neuro Oncol
Mutations in histone H3 at amino acids 27 (H3K27M) and 34 (H3G34R) occur with high-frequency in pediatric high-grade glioma. H3K27M mutations have been shown to lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition with acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4539177c8f68a138cd55721de1cb0071
https://europepmc.org/articles/PMC8598539/
https://europepmc.org/articles/PMC8598539/