Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sanish Sathyan"'
Autor:
M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The highly polygenic nature of human longevity renders pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between aging-related traits (ARTs), we aimed to model the additive variance in lifesp
Externí odkaz:
https://doaj.org/article/e7089311efc14bf3834f43d096b8f9b4
Autor:
Sanish Sathyan, Emmeline Ayers, Helena Blumen, Erica F Weiss, Dristi Adhikari, Marnina Stimmel, Kizhakkaniyakath Abdulsalam, Mohan Noone, Roy K George, Mirnova Ceide, Anne Felicia Ambrose, Cuiling Wang, Poornima Narayanan, Sachin Sureshbabu, Kunnukatil S Shaji, Alben Sigamani, Pavagada S Mathuranath, Vayyattu G Pradeep, Joe Verghese
Publikováno v:
JMIR Research Protocols, Vol 12, p e49933 (2023)
BackgroundThe southern India state of Kerala has among the highest proportion of older adults in its population in the country. An increase in chronic age-related diseases such as dementia is expected in the older Kerala population. Identifying older
Externí odkaz:
https://doaj.org/article/e46f206215be432bbb0c6f9677cf9438
Autor:
Gabriela T. Gomez, Sanish Sathyan, Jingsha Chen, Myriam Fornage, Pascal Schlosser, Zhongsheng Peng, Jenifer Cordon, Priya Palta, Kevin J. Sullivan, Adrienne Tin, B. Gwen Windham, Rebecca F. Gottesman, Josef Coresh, Nir Barzilai, Sofiya Milman, Joe Verghese, Keenan A. Walker
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 10-10 (2023)
OBJECTIVES/GOALS: Motoric cognitive risk (MCR) is a pre-dementia syndrome characterized by slow gait and subjective cognitive complaints. In the Atherosclerosis Risk in Communities (ARIC) study, we aim to (1) identify plasma proteins and protein modu
Externí odkaz:
https://doaj.org/article/fbdc928e85a849eb9ef49be079ad8157
Autor:
Joe Verghese, Emmeline Ayers, Sanish Sathyan, Richard B Lipton, Sofiya Milman, Nir Barzilai, Cuiling Wang
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253976 (2021)
BackgroundEmerging evidence suggests that there is significant variability in the progression of frailty in aging. We aimed to identify latent subpopulations of frailty trajectories, and examine their clinical and biological correlates.MethodsWe char
Externí odkaz:
https://doaj.org/article/dca223f3ec124f8e8a390f85dd999682
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Frailty is a complex aging phenotype associated with increased vulnerability to disability and death. Understanding the biological antecedents of frailty may provide clues to healthy aging. The genome-wide association study hotspot, 9p21-23 region, i
Externí odkaz:
https://doaj.org/article/7c8f49484c624ca2996c7e187b8d75f5
Autor:
Koramannil Radha Saradalekshmi, Nanoth Vellichiramal Neetha, Sanish Sathyan, Indu V Nair, Chandrasekharan M Nair, Moinak Banerjee
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98182 (2014)
DNA methylation has been implicated in the etiopathology of various complex disorders. DNA methyltransferases are involved in maintaining and establishing new methylation patterns. The aim of the present study was to investigate the inherent genetic
Externí odkaz:
https://doaj.org/article/7617ee71a7d94df19e732a1971ef7bdb
Autor:
Shabeesh Balan, Sumitha Prameela Bharathan, Neetha Nanoth Vellichiramal, Sanish Sathyan, Vijai Joseph, Kurupath Radhakrishnan, Moinak Banerjee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89253 (2014)
Epilepsy constitutes a heterogeneous group of disorders that is characterized by recurrent unprovoked seizures due to widely different etiologies. Multidrug resistance remains a major issue in clinical epileptology, where one third of patients with e
Externí odkaz:
https://doaj.org/article/1cf86b156a394d63a5d6d751160ae32b
Autor:
Sanish Sathyan, Emmeline Ayers, Dristi Adhikari, Tina Gao, Sofiya Milman, Nir Barzilai, Joe Verghese
Publikováno v:
Annals of Neurology. 93:1187-1197
Autor:
Sofiya Milman, Ben Lerman, Emmeline Ayers, Zhengdong Zhang, Sanish Sathyan, Morgan Levine, Kenny Ye, Tina Gao, Albert Higgins-Chen, Nir Barzilai, Joe Verghese
Publikováno v:
The Journals of Gerontology: Series A.
Frailty is characterized by increased vulnerability to disability and high risk for mortality in older adults. Identification of factors that contribute to frailty resilience is an important step in the development of effective therapies that protect
Publikováno v:
J Oral Biol Craniofac Res
OBJECTIVES: This study investigated genetic polymorphism of matrix metalloproteinases (MMP) −2 and −9 in oral lichen planus (OLP) and their association with the basement membrane status. STUDY DESIGN: This case-control study involved genotyping o