Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD.

Autor: Gabuza K; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa.; Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, South Africa., Mabuda TI; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa.; Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, South Africa., Patel O; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa., Khuboni N; Department of Biochemistry and Microbiology, University of Zululand, eMpangeni, South Africa., van Aarde R; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa., Riedel S; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa.; Centre for Cardio-Metabolic Research in Africa (CARMA), Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa., Sangweni NF; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa., Windvogel S; Centre for Cardio-Metabolic Research in Africa (CARMA), Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa., Johnson R; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa.; Centre for Cardio-Metabolic Research in Africa (CARMA), Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa., Muller CJF; Biomedical Research and Innovation Platform, South African Medical Research Council, Parow Valley, Cape Town, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, eMpangeni, South Africa.; Centre for Cardio-Metabolic Research in Africa (CARMA), Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.

Publikováno v: PloS one [PLoS One] 2024 Apr 17; Vol. 19 (4), pp. e0297572. Date of Electronic Publication: 2024 Apr 17 (Print Publication: 2024).

Prevention of Anthracycline-Induced Cardiotoxicity: The Good and Bad of Current and Alternative Therapies.

Autor: Sangweni NF; Biomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South Africa.; Division of Medical Physiology, Faculty of Medicine and Health Sciences, Centre for Cardio-metabolic Research in Africa, Stellenbosch University, Stellenbosch, South Africa., van Vuuren D; Division of Medical Physiology, Faculty of Medicine and Health Sciences, Centre for Cardio-metabolic Research in Africa, Stellenbosch University, Stellenbosch, South Africa., Mabasa L; Biomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South Africa., Gabuza K; Biomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South Africa., Huisamen B; Division of Medical Physiology, Faculty of Medicine and Health Sciences, Centre for Cardio-metabolic Research in Africa, Stellenbosch University, Stellenbosch, South Africa., Naidoo S; Biomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South Africa.; Division of Medical Physiology, Faculty of Medicine and Health Sciences, Centre for Cardio-metabolic Research in Africa, Stellenbosch University, Stellenbosch, South Africa., Barry R; Research and Development Department, BioPharm, Hamilton, New Zealand., Johnson R; Biomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South Africa.; Division of Medical Physiology, Faculty of Medicine and Health Sciences, Centre for Cardio-metabolic Research in Africa, Stellenbosch University, Stellenbosch, South Africa.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Jun 22; Vol. 9, pp. 907266. Date of Electronic Publication: 2022 Jun 22 (Print Publication: 2022).

Sclerocarya birrea (Marula) Extract Inhibits Hepatic Steatosis in db/db Mice.

Autor: Mabasa L; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa., Kotze A; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.; Centre for Cardiometabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa., Shabalala S; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.; Division of Medical Microbiology, Department of Pathology and Laboratory-Medicine, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5117, South Africa., Kimani C; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.; Institute of Primate Research, P.O. Box 24481, Karen, Nairobi 00502, Kenya., Gabuza K; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa., Johnson R; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.; Centre for Cardiometabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa., Sangweni NF; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.; Centre for Cardiometabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa., Maharaj V; Department of Chemistry, University of Pretoria, Pretoria 0001, South Africa., Muller CJF; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.; Centre for Cardiometabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3880, South Africa.

Publikováno v: International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Mar 22; Vol. 19 (7). Date of Electronic Publication: 2022 Mar 22.

The triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA3), attenuates high glucose-induced oxidative damage and apoptosis by improving energy metabolism.

Autor: Sangweni NF; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa. Electronic address: nonhlakanipho.sangweni@mrc.ac.za., Mosa RA; Department of Biochemistry, Genetics and Microbiology (BGM), Division of Biochemistry, University of Pretoria, Hatfield 0028, South Africa., Dludla PV; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona 60131, Italy. Electronic address: phiwayinkosi.dludla@mrc.ac.za., Kappo AP; Department of Biochemistry, Faculty of Science, University of Johannesburg, Auckland Park 2006, South Africa., Opoku AR; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Muller CJF; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa. Electronic address: christo.muller@mrc.ac.za., Johnson R; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa. Electronic address: rabia.johnson@mrc.ac.za.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 May; Vol. 85, pp. 153546. Date of Electronic Publication: 2021 Mar 10.

In Utero One-Carbon Metabolism Interplay and Metabolic Syndrome in Cardiovascular Disease Risk Reduction.

Autor: Mabasa L; South African Medical Research Council, Tygerberg, Cape Town, South Africa., Samodien E; South African Medical Research Council, Tygerberg, Cape Town, South Africa., Sangweni NF; South African Medical Research Council, Tygerberg, Cape Town, South Africa.; Stellenbosch University, Tygerberg, South Africa., Pheiffer C; South African Medical Research Council, Tygerberg, Cape Town, South Africa.; Stellenbosch University, Tygerberg, South Africa., Louw J; South African Medical Research Council, Tygerberg, Cape Town, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa., Johnson R; South African Medical Research Council, Tygerberg, Cape Town, South Africa.; Stellenbosch University, Tygerberg, South Africa.

Publikováno v: Molecular nutrition & food research [Mol Nutr Food Res] 2020 Feb; Vol. 64 (4), pp. e1900377. Date of Electronic Publication: 2019 Aug 26.